Current status of hepatic resection for hepatocellular carcinoma

Abstract

Hepatocellular carcinoma (HCC) is one of the most common tumors worldwide. For this disease, a variety of therapeutic measures have been applied, including hepatic resections, total hepatectomy followed by allografting, transarterial chemoembolization, and percutaneous tumor ablative therapy by ethanol, microwave coagulation, and radiofrequency ablation. This article focuses on the current status of hepatic resections for HCC.

Nucleotide Analogs for Patients with HBV-Related Hepatocellular Carcinoma Increase the Survival Rate through Improved Liver Function

“…Although hepatic resection and radiofrequency ablation (RFA) are recognized as curative treatments, many cirrhotic patients cannot repeatedly undergo curative treatments due to the deterioration of liver function after treatment. Furthermore, liver function is the most critical prognostic factor of treatment for HCC (10)(11)(12). It is very important to maintain adequate liver function when undergoing therapy and to suppress the recurrence of HCC in order to improve survival; however, HBV-related chronic liver disease gradually progresses to cirrhosis and hepatic decompensation, and leads to a higher probability of contracting HCC.…”

Glasgow prognostic score predicts therapeutic outcome after hepatic resection for hepatocellular carcinoma

“…Therefore, it is important to clarify the predictor of HCC recurrence and prognosis for decision making in additional adjuvant treatment after hepatic resection, preoperatively. Several investigators have reported tumor size, vascular invasion, intrahepatic metastasis, tumor markers, excessive blood loss, and allogenic blood transfusion as factors associated with recurrence of HCC (4)(5)(6)(7). Unlike other solid malignancies, the prognosis of HCC is not solely dependent on tumor burden but also adversely influenced by impaired liver function secondary due to the underlying pathogenic condition (8).…”

Concurrent and subsequent radiofrequency ablation combined with hepatectomy for hepatocellular carcinomas

“…In patients with HCC in a cirrhotic liver, preoperative evaluation including Child-Pugh classification, indocyanine green retention test, and volumetric analysis is essential [2,3,[24][25][26][27][28][29] . Although survival after resection for properly selected candidates can reach 70% at 5 years [2] , large series of resections for HCCs reported moderate or good, 3-year and 5-year survival rates between 51%-73% and 34%-59%, respectively [29][30][31][32] .…”

“…Although survival after resection for properly selected candidates can reach 70% at 5 years [2] , large series of resections for HCCs reported moderate or good, 3-year and 5-year survival rates between 51%-73% and 34%-59%, respectively [29][30][31][32] . Choi et al [22] demonstrated that resection plus RFA provided long-term survival comparable to that with hepatectomy alone.…”