Current Status of Lung Cancer and Surgery Based on Studies Using a Nationwide Database

Abstract

Lung cancer is a fatal disease, highlighting the importance of research on related topics, including surgery for lung cancer. However, systematic research analyzing surgery on a national scale is limited. This study aimed to investigate the research on lung cancer using nationwide data in South Korea and to analyze trends in lung cancer surgery, including its clinical implications. Published articles and data from the Korean National Health Insurance database were used. Although the incidence and mortality of lung cancer have been improving, it is predicted to be the most common and fatal type of cancer in South Korea in 2021. The number of surgical procedures for lung cancer is increasing, especially among women, those ≥76 years of age, residents of non-metropolitan cities, and middle-income patients. Lobectomy and sublobectomy, including segmentectomy, are increasingly common. However, the proportion of pneumonectomy relative to other procedures is not increasing. Surgery has shown a reasonable survival rate, especially after lobectomy, but survival remains poor in patients ≥76 years of age who undergo pneumonectomy. The frequency of lung cancer surgery is increasing concomitantly with various socioeconomic changes. Lobectomy has become increasingly common, and the clinical results of surgery are satisfactory. Further research on the changing composition of surgical candidates is required.

Identification of the potential ferroptosis key genes in lung cancer with bone metastasis

“…The 5-year survival rate for lung cancer patients in the United States is around 16% and less than 10% in the United Kingdom. Lung cancer has become one of the deadliest malignant tumors globally ( 2 , 3 ). In China, the incidence (21.9%) and mortality (26.4%) rates of lung cancer rank first among all malignancies in male patients, while among female cancer patients, its incidence rate (13.3%) ranks second only to breast cancer, and its mortality rate (11.1%) ranks first ( 4 ).…”

Effects of psychological nursing care on anxiety and depression in perioperative patients with lung cancer: A systematic review and meta-analysis

“…Various modalities have been reported to treat such disorders, including surgical resection, chemotherapy, radiotherapy, targeted management, and alternative therapy, especially surgery. [16][17][18][19][20][21][22][23][24] Although an increasing number of patients with LC benefit from surgery, they experience uncomfortable disorders such as physical function, quality of life, anxiety, depression, and adverse events (AEs). [25][26][27][28][29] Based on routine nursing care (RNC), including health education and guidance of medication and diet, psychological nursing care (PNC) refers to cognitive, emotional, and behavioral interventions.…”

Significance of Spread Through Air Spaces and Vascular Invasion in Early-stage Adenocarcinoma Survival

“…[1][2][3] Despite the viability of radical surgery for early-stage adenocarcinomas (ADCs), only up to 25% of patients are deemed suitable for surgery upon diagnosis, resulting in unsatisfactory overall survival (OS) particularly in cases of widespread disease with metastases detected at the time of diagnosis. 4,5 In the exploration of tumor escape mechanisms in lung adenocarcinoma, it is crucial to emphasize two pivotal parameters: spread through the air space (STAS) and vascular invasion (VI). STAS, introduced in the 2015 WHO classification as a prognostic pathologic parameter, 6 has been a subject of debate, with some authors considering it a potential artifact resulting from sample preparation procedures or an artificial phenomenon associated with preoperative or intraoperative manipulation.…”

“…Lung cancer stands as one of the leading global causes of mortality, and surgical resection remains a fundamental approach in managing early and locally advanced non-small cell lung cancer (NSCLC) 1–3 . Despite the viability of radical surgery for early-stage adenocarcinomas (ADCs), only up to 25% of patients are deemed suitable for surgery upon diagnosis, resulting in unsatisfactory overall survival (OS) particularly in cases of widespread disease with metastases detected at the time of diagnosis 4,5 …”