Current Status of Myocardial Perfusion PET in the United States

Bateman, Timothy M.

doi:10.17996/anc.17-00047

Cited by 10 publications

(4 citation statements)

References 27 publications

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“…The kinetics of Rb + are similar to those of K + 7 , and therefore, 82 Rb + has been widely used as a perfusion imaging tracer with PET in the United States (USA). 8 In addition, the use of a positron-emitting isotope of K, potassium-38, has been also reported. 9 Trivalent cations of gallium-67 ( 67 Ga 3+ ), a γ-emitter, have been used to detect inflammatory lesions.…”

Section: Tracers Used For Cardiac Imaging (Table 1 mentioning

confidence: 99%

Radiopharmaceutical tracers for cardiac imaging

Manabe

Kikuchi

Scholte

et al. 2018

Journal of Nuclear Cardiology

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Cardiovascular disease (CVD) is the leading cause of death and disease burden worldwide. Nuclear myocardial perfusion imaging with either single-photon emission computed tomography or positron emission tomography has been used extensively to perform diagnosis, monitor therapies, and predict cardiovascular events. Several radiopharmaceutical tracers have recently been developed to evaluate CVD by targeting myocardial perfusion, metabolism, innervation, and inflammation. This article reviews old and newer used in nuclear cardiac imaging.Electronic supplementary materialThe online version of this article (10.1007/s12350-017-1131-5) contains supplementary material, which is available to authorized users.

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Section: Tracers Used For Cardiac Imaging (Table 1 mentioning

confidence: 99%

Radiopharmaceutical tracers for cardiac imaging

Manabe

Kikuchi

Scholte

et al. 2018

Journal of Nuclear Cardiology

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“…On the other hand, 82 Rb has the potential for wide clinical since it does not require a cyclotron for production. Actually, the number of PET perfusion studies in the US has risen, mainly due to the use of 82 Rb generators (5,13). 82 Rb is useful for centers that perform many patient studies since it has a shelf-life of 1-2 months and can be produced using one generator system without a cyclotron.…”

Section: Comparison Of Pet Tracersmentioning

confidence: 99%

“…While single-photon emission computed tomography (SPECT) MPI has been used in clinical settings, positron emission tomography (PET) MPI has several advantages over SPECT MPI. PET MPI has been shown to have more accurate diagnostic value than does SPECT MPI, and high incremental prognostic value in patients with CAD (1)(2)(3)(4)(5). Another big advantage of PET over SPECT is better quantification of tracer kinetics.…”

mentioning

confidence: 99%

Positron Emission Tomography Myocardial Perfusion Imaging Tracer Choice for Assessment of Myocardial Blood Flow

Tamaki

Yoshinaga²

2019

Annals of Nuclear Cardiology

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Myocardial perfusion imaging (MPI) using positron emission tomography (PET) has high diagnostic accuracy and prognostic value in patients with known or suspected coronary artery disease (CAD). In addition, PET MPI can be used to quantify global left ventricle (LV) and regional LV myocardial blood flow (MBF) and myocardial flow reserve (MFR). Currently, there are four major PET perfusion tracers: 82 rubidium, 13 N-ammonia, 15 Owater, and 18 F-flurpiridaz. The characteristics of each tracer have been described and fully compared. Given increasing clinical needs for accurate MBF and MFR measurements, the use of PET MPI should be expanded in clinical settings in the near future.

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“…While SPECT is the predominant modality for MPI, PET can provide superior image quality and better diagnostic accuracy (Jaarsma et al 2012, Parker et al 2012, Manabe et al 2020. Following rubidium-82 ( 82 Rb) and nitrogen-13 ( 13 N) ammonia, 18 F-flurpiridaz has been developed as a PET MPI tracer, and some phase 3 clinical trials are in progress (Bateman 2017, Werner et al 2019. Recently, Maddahi, et al reported results of the first phase 3 trial (Maddahi et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Design consideration of compact cardiac TOF-PET systems: a simulation study

Akamatsu¹,

Tashima²,

Takyu³

et al. 2021

Phys. Med. Biol.

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Myocardial perfusion imaging (MPI) with PET plays a vital role in the management of coronary artery disease. High sensitivity systems can contribute to maximizing the potential value of PET MPI; therefore, we have proposed two novel detector arrangements, an elliptical geometry and a D-shape geometry, that are more sensitive and more compact than a conventional large-bore cylindrical geometry. Here we investigate two items: the benefits of the proposed geometries for cardiac imaging; and the effects of scatter components on cardiac PET image quality. Using the Geant4 toolkit, we modeled four time-of-flight (TOF) PET systems: an 80 cm diameter cylinder, a 40 cm diameter cylinder, a compact ellipse, and a compact D-shape. Spatial resolution and sensitivity were measured using point sources. Noise equivalent count rate and image quality were examined using an anthropomorphic digital chest phantom. The proposed geometries showed higher sensitivity and better count rate characteristics with a fewer number of detectors than the conventional large-bore cylindrical geometry. In addition, we found that the increased intensity of the scatter components was a big factor affecting the contrast in defect regions for such a compact geometry. It is important to address the issue of the increased intensity of the scatter components to develop a high-performance compact cardiac TOF PET system.

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Current Status of Myocardial Perfusion PET in the United States

Cited by 10 publications

References 27 publications

Radiopharmaceutical tracers for cardiac imaging

Radiopharmaceutical tracers for cardiac imaging

Positron Emission Tomography Myocardial Perfusion Imaging Tracer Choice for Assessment of Myocardial Blood Flow

Design consideration of compact cardiac TOF-PET systems: a simulation study

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