Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis – A review

Prasanna, Pragya; Kumar, Prakash; Kumar, Saurabh; Rajana, Vinod Kumar; Kant, Vishnu; Prasad, Surendra Rajit; Mohan, Utpal; Ravichandiran, V.; Mandal, Debabrata

doi:10.1016/j.biopha.2021.111920

Cited by 41 publications

(22 citation statements)

References 227 publications

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“…The most recent approvals were given to mRNA-Covid-19 vaccines that use lipid nanoparticles to deliver mRNA to monocytes and dendritic cell subsets for immunization against SARS-CoV-2 (Shan et al, 2022;Trougakos et al, 2022). Yet after almost two decades since the approval of Doxil, no nanomedicine has been approved for the treatment of CD and only the nanomedicine liposomal amphotericin B (LAmpB)has been approved for the treatment of leishmaniasis, despite the very high cost of this treatment (Prasanna et al, 2021;Assolini et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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Nanotechnology is revolutionizing many sectors of science, from food preservation to healthcare to energy applications. Since 1995, when the first nanomedicines started being commercialized, drug developers have relied on nanotechnology to improve the pharmacokinetic properties of bioactive molecules. The development of advanced nanomaterials has greatly enhanced drug discovery through improved pharmacotherapeutic effects and reduction of toxicity and side effects. Therefore, highly toxic treatments such as cancer chemotherapy, have benefited from nanotechnology. Considering the toxicity of the few therapeutic options to treat neglected tropical diseases, such as leishmaniasis and Chagas disease, nanotechnology has also been explored as a potential innovation to treat these diseases. However, despite the significant research progress over the years, the benefits of nanotechnology for both diseases are still limited to preliminary animal studies, raising the question about the clinical utility of nanomedicines in this field. From this perspective, this review aims to discuss recent nanotechnological developments, the advantages of nanoformulations over current leishmanicidal and trypanocidal drugs, limitations of nano-based drugs, and research gaps that still must be filled to make these novel drug delivery systems a reality for leishmaniasis and Chagas disease treatment.

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Section: Introductionmentioning

confidence: 99%

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Scariot

Staneviciute

Zhu

et al. 2022

Front. Cell. Infect. Microbiol.

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“…Generation of new AmB derivatives 43 , 44 or its nano-formulation with reduced toxicity 24 , 45 – 47 was reported with some success. But due to the lack of vaccine 48 and drug resistance and toxicity associated with AmB, the idea of nano and micro-formulation 49 , natural product-based drug-delivery 6 using flavonoids or its formulation 50 , 51 , marine products 52 and even drug-repurposing 53 have gained significant attention for the treatment of various forms of leishmaniasis. In this study, we have confirmed the antileishmanial efficacy of CA, a natural FA that is already known to have antibacterial/antifungal efficacy.…”

Section: Discussionmentioning

confidence: 99%

Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani

Prasad

Kumar

Mandal

et al. 2022

Sci Rep

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We evaluated the anti-leishmanial efficacy of different saturated medium-chain fatty acids (FAs, C8–C18) where FA containing C8 chain, caprylic acid (CA), was found to be most potent against Leishmania donovani, the causative agent for visceral leishmaniasis (VL). Different analogs of CA with C8 linear chain, but not higher, along with a carboxyl/ester group showed a similar anti-leishmanial effect. Ergosterol depletion was the major cause of CA-mediated cell death. Molecular docking and molecular dynamic simulation studies indicated the enzyme mevalonate kinase (MevK) of the ergosterol biosynthesis pathway as a possible target of CA. Enzyme assays with purified recombinant MevK and CA/CA analogs confirmed the target with a competitive inhibition pattern. Using biochemical and biophysical studies; strong binding interaction between MevK and CA/CA analogs was established. Further, using parasites with overexpressed MevK and proteomics studies of CA-treated parasites the direct role of MevK as the target was validated. We established the mechanism of the antileishmanial effect of CA, a natural product, against VL where toxicity and drug resistance with current chemotherapeutics demand an alternative. This is the first report on the identification of an enzymatic target with kinetic parameters and mechanistic insights against any organism for a natural medium-chain FA.

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“…Nanosensors act as nano-carriers envisaged to replace the agrochemicals due to their biological compatibility, less soil contamination, efficiency, and precise release of active substances, increased solubilization, and penetration into plant and target tissues ( Prasanna et al, 2021 ). Nanosensors are chosen over the conventional sensors due to nanoscale size, highest sensitivity, efficient signal transduction mechanism, turn off/on mechanism, and durability ( Scognamiglio, 2013 ).…”

Section: Applications Of Nanotechnology In Agriculturementioning

confidence: 99%

Agri-Nanotechnology and Tree Nanobionics: Augmentation in Crop Yield, Biosafety, and Biomass Accumulation

Abbas

et al. 2022

Front. Bioeng. Biotechnol.

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Nanomaterials (NMs) are the leading edge as an amazing class of materials that consists of at least one dimension in the range of 1–100 nm. NMs can be made with exceptional magnetic, electrical, and catalytic properties different from their bulk counterparts. We summarized unique features of NMs, their synthesis, and advances in agri-nanotechnology and cutting-edge nanobionics. The review describes advances in NMs including their applications, dosimetry to ensure biosafety, remote sensing of agro-forestry fields, nanofertilizers, and nanopesticides, and avoid post-harvest losses, gene delivery, and nanobionics. Tree nanobionics has enabled the synthesis and delivery of nanosensors, which enhance the rate of photosynthesis, detection of pathogens, and poisonous residues to ensure biosafety and biomass accumulation. Finally, we conclude by discussing challenges, future perspectives, and agro-ecological risks of using NMs.

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Current status of nanoscale drug delivery and the future of nano-vaccine development for leishmaniasis – A review

Cited by 41 publications

References 227 publications

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Leishmaniasis and Chagas disease: Is there hope in nanotechnology to fight neglected tropical diseases?

Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani

Agri-Nanotechnology and Tree Nanobionics: Augmentation in Crop Yield, Biosafety, and Biomass Accumulation

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