Current Status of Natural Products/siRNA Co‐Delivery for Cancer Therapy

Abstract

siRNA interference is a conserved cellular gene silencing mechanism and a viable technique for human disease intervention, including cancer. This method has significant potential benefits over currently available treatments. The limitations of using siRNA‐based systems are the lack of specificity, high chance of degradation, toxicity, and ineffective cellular uptake. Combination therapy using natural compounds possesses higher therapeutical value with siRNA. Various natural compounds are used in cancer treatments such as paclitaxel, ursolic acid, hypericin, etoposide, etc due to their diverse bioactivities. In this review, the codelivery of natural compounds/siRNA using nanovehicles is highlighted.