Current status of nuclear cardiology in the Russian Federation

Zavadovsky, K. V.; Vesnina, Zh. V.; Anashbaev, Zh. Zh.; Мочула, А. В.; Сазонова, С. И.; Ilyushenkova, Julia N.; Шипулин, В. М.; Varlamova, Yu. V.; Аншелес, А. А.; Асланиди, И. П.; Valiullina, N. M.; Вахромеева, М Н; Volodina, V. V.; Давыдов, Г. А.; Drizner, E. A.; Znamenskiy, I. A.; Karpov, E. N.; Kokov, А. N.; Kudryashova, N. E.; Минин, С. М.; Mirzoyants, S. G.; Ryzhkova, D. V.; Sadchikov, A. A.; Sayfullina, G. B.; Сергиенко, В. Б.; Smolyarchuk, M. Ya.; Starikova, E. V.; Sukhov, V. Yu.; Talantov, S. V.; Tempel, M. V.; Teffenberg, D. V.; Tomashevsky, I. O.; Трифонова, Т. А.; Udodov, V. D.; Chernov, Vladimir; Шурупова, И.В.

doi:10.15829/1560-4071-2022-5134

Russ J Cardiol

2023

DOI: 10.15829/1560-4071-2022-5134

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Current status of nuclear cardiology in the Russian Federation

K. V. Zavadovsky

Zh. V. Vesnina

Zh. Zh. Anashbaev

et al.

Abstract: The article is devoted to the analysis of the current status of nuclear cardiology in the Russian Federation. The data on the number of facilities performing radionuclide investigations for the diagnosis and monitoring of the treatment of cardiovascular diseases, their staffing and equipment are given. The statistics of the conducted nuclear cardiology tests for 2018-2020 are given, as well as their methods, features and diagnostic significance are described.

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Cited by 4 publications

References 38 publications

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Targeted Nuclear Medicine. Achievements, Challenges and Prospects

Kovalchuk,

Deyev,

Sergunova

2023

Nanotechnol Russia

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The path of the development of nuclear medicine at the international level and that in Russia is presented. Significant achievements in the development and establishment of nuclear-physics technologies and the development of targeted radiopharmaceuticals (RPs) are presented. The main directions of targeted nuclear medicine are shown. The physical–chemical aspects of the synthesis of radiopharmaceuticals are considered, and the advantages and specificity of vector carrier molecules are shown.

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Targeted Nuclear Medicine. Achievements, Challenges and Prospects

Kovalchuk,

Deyev,

Sergunova

2023

Nanotechnol Russia

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99mTc-MIBI washout rate as a marker of myocardial mitochondrial dysfunction: A systematic review and meta-analysis

Gulya,

Zavadovsky

2023

Digital Diagnostics

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The systemic review and metaanalysis describes the features of the 99mTc-MIBI pharmacokinetics, which make it possible to assess mitochondrial myocardial dysfunction in vivo, and also shows the main clinical application points the phenomenon of accelerated 99mTc-MIBI washout rate. The study of foreign and domestic literature described the informativeness of the reverse redistribution phenomenon and the 99mTc-MIBI washout rate as a marker of mitochondrial myocardial dysfunction was carried out. The analysis included publications selected by the following keywords and their combinations: mitochondrial dysfunction, 99mTc-MIBI, 99mTc-Tetrofosmin, myocardial perfusion scintigraphy, reverse redistribution, washout rate. A total of 17 publications have been collected for a systematic review of clinical studies in the field of studying and evaluating mitochondrial dysfunction according to myocardial perfusion scintigraphy. 6 studies with a case-control design were selected to perform the metaanalysis. An analysis of the literature shows that the severity of the reverse redistribution phenomenon and 99mTc-MIBI washout rate are associated with the microstructure of mitochondria and myocardium, contractility and hemodynamics of the left ventricle, the level of natriuretic peptides, exercise tolerance, severity of coronary atherosclerosis, oxidative metabolism of the myocardium, the risk of cardiovascular events. According to the data of the meta-analysis, it was found that the rate of washout rate was statistically significantly accelerated in patients with heart pathology, as compared to the control. Thus, the assessment of mitochondrial function by 99mTc-MIBI washout assessment can provide additional information about the functional state of the myocardium.

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Formation of structural and functional changes in the myocardium in individuals with different metabolic phenotypes: A literature review

Postoeva,

Mirolyubova,

Dvoryashina

2024

Medicinskij sovet

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Cardiovascular mortality still takes leading places among causes of mortality from different disease in developed countries including Russian Federation. Influence of adipose tissue excess on myocardium is widely discussed in scientific literature. The concept of metabolic phenotypes was suggested as a new way for study of impact of obesity and concomitant metabolic disorders in to the risk of cardiovascular diseases and mortality from them. In this review we discussed the accumulated experience of the Russian and international trials about structural and functional characteristics of myocardium described with various instrumental methods of diagnosis. Special attention is focused on the description of echocardiography as the most available visualizing method, actual diagnostic criteria of disturbances are provided according to Russian and international guidelines. Features and methods of diagnosis of diastolic dysfunction and cardiac remodeling in terms of heart failure with preserved ejection fraction in people with various metabolic phenotypes are discussed. The majority of authors declare the absence of evident decrease of systolic function, as a result the estimation of diastolic dysfunction is very actual. Issues connected to historical transformation of the term obesity paradox and obese cardiopathy, myocardial fat ectopy are covered. The results of experimental and morphological studies present the facts about different impact of adipose tissue and metabolic disorders to development changes in myocardium.

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Current status of nuclear cardiology in the Russian Federation

Cited by 4 publications

References 38 publications

Targeted Nuclear Medicine. Achievements, Challenges and Prospects

Targeted Nuclear Medicine. Achievements, Challenges and Prospects

99mTc-MIBI washout rate as a marker of myocardial mitochondrial dysfunction: A systematic review and meta-analysis

Formation of structural and functional changes in the myocardium in individuals with different metabolic phenotypes: A literature review

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