Current status of terpenoids as inflammasome inhibitors

Hortelano, Sonsoles; González‐Cofrade, Laura; Cuadrado, Irene; Herrero, Beatriz de las Heras

doi:10.1016/j.bcp.2019.113739

Cited by 24 publications

(15 citation statements)

References 87 publications

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“…These compounds are widely distributed in many plants, mainly in aerial parts (leaves and stems) and underground parts (roots). The anti-inflammatory potential of terpenes were described by Hortelano et al [23], revealing that these compounds can be promising natural therapeutic agents. As can be seen in Table 2, terpenes from turmeric species (Curcuma sp.)…”

Section: Anti-inflammatory Activitymentioning

confidence: 95%

Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources

Poletto

Álvarez-Rivera

Torres

et al. 2020

TrAC Trends in Analytical Chemistry

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Section: Anti-inflammatory Activitymentioning

confidence: 95%

Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources

Poletto

Álvarez-Rivera

Torres

et al. 2020

TrAC Trends in Analytical Chemistry

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“…Terpenoids and flavonoids are abundantly present in cannabis extracts, and both molecule groups exhibit antiinflammatory activities. Many terpenoids and flavonoids are inflammasome inhibitors in general and are reviewed extensively elsewhere (214)(215)(216)(217), a subject beyond the scope of this review.…”

Section: Synthetic Cannabinoidsmentioning

confidence: 99%

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

Suryavanshi

Kovalchuk

2021

Front. Immunol.

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Inflammasomes are cytoplasmic inflammatory signaling protein complexes that detect microbial materials, sterile inflammatory insults, and certain host-derived elements. Inflammasomes, once activated, promote caspase-1–mediated maturation and secretion of pro-inflammatory cytokines, interleukin (IL)-1β and IL-18, leading to pyroptosis. Current advances in inflammasome research support their involvement in the development of chronic inflammatory disorders in contrast to their role in regulating innate immunity. Cannabis (marijuana) is a natural product obtained from the Cannabis sativa plant, and pharmacologically active ingredients of the plant are referred to as cannabinoids. Cannabinoids and cannabis extracts have recently emerged as promising novel drugs for chronic medical conditions. Growing evidence indicates the potent anti-inflammatory potential of cannabinoids, especially Δ9-tetrahydrocannabinol (Δ9-THC), cannabidiol (CBD), and synthetic cannabinoids; however, the mechanisms remain unclear. Several attempts have been made to decipher the role of cannabinoids in modulating inflammasome signaling in the etiology of chronic inflammatory diseases. In this review, we discuss recently published evidence on the effect of cannabinoids on inflammasome signaling. We also discuss the contribution of various cannabinoids in human diseases concerning inflammasome regulation. Lastly, in the milieu of coronavirus disease-2019 (COVID-19) pandemic, we confer available evidence linking inflammasome activation to the pathophysiology of COVID-19 suggesting overall, the importance of cannabinoids as possible drugs to target inflammasome activation in or to support the treatment of a variety of human disorders including COVID-19.

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“…Identifying NLRP3 inhibitors in plant-derived natural products is of great importance for drug discovery as they are mostly safe, extensively distributed, and widely available. Among all the compounds, the diterpenoids may be the most promising candidates, for they possess combined inhibitory effect on NF-κB (the first signal of NLRP3 activation) pathway and NLRP3 inflammasome assembly (Hortelano et al, 2020). In this review, we have only summarized the natural products for which there is direct evidence that their antifibrotic effects are exerted via suppression of the NLRP3 inflammasome.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Natural Products that Target the NLRP3 Inflammasome to Treat Fibrosis

Ding

Wei

et al. 2020

Front. Pharmacol.

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Fibrosis is a common pathway followed by different organs after injury, and it can lead to parenchymal scarring, cellular dysfunction, and even organ failure. The NLRP3 inflammasome is a multiprotein complex composed of the sensor molecule NLRP3, the adaptor apoptosis-associated speck-like protein containing a CARD (ASC), and the effector protease caspase-1. Overactivation of the NLRP3 inflammasome triggers the abundant secretion of IL-1β and IL-18, induces pyroptosis, and promotes the release of a swathe of proinflammatory proteins, all of which contribute to fibrogenic processes in multiple organs. In recent years, screening bioactive natural compounds for NLRP3 inhibitors to alleviate fibrosis has gained broad interest from the scientific community because of the associated cost-effectiveness and easy access. In this review, we systematically and comprehensively summarize the natural products, including terpenoids, phenols, and alkaloids, among others, and the plant-derived crude extracts, that have been reported to ameliorate fibrosis via inhibiting NLRP3 inflammasome activation and highlight the underlying mechanisms. Among all the compounds, diterpenoids is the most promising candidates for inhibiting NLRP3 inflammasome activation and improving fibrosis, as they possess combined inhibitory effect on NLRP3 inflammasome assembly and NF-κB signaling pathway. All the information may aid in the development of therapeutic strategies for the treatment of fibrotic diseases.

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Current status of terpenoids as inflammasome inhibitors

Cited by 24 publications

References 87 publications

Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources

Compressed fluids and phytochemical profiling tools to obtain and characterize antiviral and anti-inflammatory compounds from natural sources

Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective

Natural Products that Target the NLRP3 Inflammasome to Treat Fibrosis

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