Current status of the association between malnutrition defined by the GLIM criteria and postoperative outcomes in gastrointestinal surgery for cancer: a narrative review

Matsui, Ryota; Rifu, Kazuma; Watanabe, Jun; Inaki, Noriyuki; Fukunaga, Tetsu

doi:10.1007/s00432-022-04175-y

Cited by 12 publications

(8 citation statements)

References 47 publications

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“…Furthermore, the main drivers of good postoperative surgical outcomes are usually the healing of anastomoses and wounds, bowel motility, and return to normal physical activities in GI oncologic resections. Markers of malnutrition and low physical fitness have been correlated with the impairment of postoperative surgical outcomes [ 61 ]. Thus, the assessment of postoperative nutritional markers is essential to identify the benefits of prehabilitation and induce changes in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Surgical Prehabilitation in Patients with Gastrointestinal Cancers: Impact of Unimodal and Multimodal Programs on Postoperative Outcomes and Prospects for New Therapeutic Strategies—A Systematic Review

Mareschal

Hemmer

Douissard

et al. 2023

Cancers

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The advantages of prehabilitation in surgical oncology are unclear. This systematic review aims to (1) evaluate the latest evidence of preoperative prehabilitation interventions on postoperative outcomes after gastrointestinal (GI) cancer surgery and (2) discuss new potential therapeutic targets as part of prehabilitation. Randomized controlled trials published between January 2017 and August 2022 were identified through Medline. The population of interest was oncological patients undergoing GI surgery. Trials were considered if they evaluated prehabilitation interventions (nutrition, physical activity, probiotics and symbiotics, fecal microbiota transplantation, and ghrelin receptor agonists), alone or combined, on postoperative outcomes. Out of 1180 records initially identified, 15 studies were retained. Evidence for the benefits of unimodal interventions was limited. Preoperative multimodal programs, including nutrition and physical activity with or without psychological support, showed improvement in postoperative physical performance, muscle strength, and quality of life in patients with esophagogastric and colorectal cancers. However, there was no benefit for postoperative complications, hospital length of stay, hospital readmissions, and mortality. No trial evaluated the impact of fecal microbiota transplantation or oral ghrelin receptor agonists. Further studies are needed to confirm our findings, identify patients who are more likely to benefit from surgical prehabilitation, and harmonize interventions.

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Section: Discussionmentioning

confidence: 99%

Surgical Prehabilitation in Patients with Gastrointestinal Cancers: Impact of Unimodal and Multimodal Programs on Postoperative Outcomes and Prospects for New Therapeutic Strategies—A Systematic Review

Mareschal

Hemmer

Douissard

et al. 2023

Cancers

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“…4 A recent study reported the utility of the definition of malnutrition using the GLIM criteria in many types of cancers and chronic inflammatory disease. [5][6][7][8][9][10] The GLIM criteria were developed to provide universal diagnostic criteria for malnutrition and to support standardized treatments. 11 According to the GLIM criteria, malnutrition is diagnosed based on the presence of at least one phenotypic (nonvolitional weight loss, low BMI, and reduced skeletal muscle 1236 -HARIMOTO ET AL.…”

Section: Introductionmentioning

confidence: 99%

“…A recent study reported the utility of the definition of malnutrition using the GLIM criteria in many types of cancers and chronic inflammatory disease 5–10 . The GLIM criteria were developed to provide universal diagnostic criteria for malnutrition and to support standardized treatments 11 .…”

Section: Introductionmentioning

confidence: 99%

Significance of malnutrition defined with Global Leadership Initiative on Malnutrition criteria in patients with hepatocellular carcinoma after hepatic resection

Harimoto,

Tsukagoshi,

Okuyama

et al. 2023

Hepatology Research

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AimA recent study reported the utility of the malnutrition defined the Global Leadership Initiative on Malnutrition (GLIM) criteria in many types of cancers and chronic inflammatory disease. The present retrospective study aimed to investigate the significance of the malnutrition defined with GLIM criteria in patients with hepatic resection for hepatocellular carcinoma (HCC) and also to compare the malnutrition using hand grip strength.MethodsWe retrospectively reviewed data from 174 patients who had undergone curative hepatic resection for HCC including both skeletal muscle area and hand grip strength. Patients were divided to malnutrition defined by GLIM or modified GLIM and clinicopathological and short‐ and long‐term outcomes were analyzed. The modified GLIM criteria was defined using both hand grip strength and skeletal muscle area.ResultsThe malnutrition defined by GLIM criteria were 47 patients (26.7%) and malnutrition defined by modified GLIM criteria were 21 patients (11.9%). The malnutrition defined by GLIM or modified GLIM criteria were both associated with poorer liver function and malignant tumor behavior, but modified GLIM criteria predicted the postoperative complication and recurrence‐free survival outcome independently. In patients with poor liver function, malnutrition defined by modified GLIM criteria predicted postoperative complication and overall and recurrence‐free survival.ConclusionsThe malnutrition defined by modified GLIM criteria using both hand grip strength and skeletal muscle area can predict more accurately the short‐term and long‐term outcome compared to malnutrition defined by the GLIM criteria. Nutritional and exercise therapy may become more important in patients with malnutrition and poor liver function.This article is protected by copyright. All rights reserved.

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“…At the same time, proteolysis leads the negative nitrogen balance. When this catabolic phase is severe, many patients tend to have a poor prognosis [3][4][5][6][7][8][9] . This trend applies to critically ill and neurological critically ill pa-tients 10) .…”

Section: Introductionmentioning

confidence: 99%

Analysis of Nitrogen Balance Test in Patients With Traumatic Brain Injury

Kim

2023

J Neurointensive Care

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Background: This study aimed to analyze the catabolic phases of patients with traumatic brain injury (TBI) by performing the Nitrogen Balance Test (NB Test).Methods: This single-centered, retrospective study included data from 292 patients who underwent NB tests from 2019 to 2022 and categorized them as TBI and Non-TBI groups. The basic clinical factors (gender, age, and initial GCS), critical care factors (APACHE, SOFA, and ICU stay days), and outcomes (GOS). The trend of the NB test was investigated in all groups and analyzed the statistical correlation of the NB test was with severity, critical care factors, and outcomes. Results: A total of 52 patients were found to have TBI. The 26 out of 52 TBI patients underwent the second NB test 1 week after the first NB test. The deficiency of protein calculated was 24.375 g. There was a significant statistical difference of NB test patterns between the non-TBI and TBI patients.Conclusion: Physicians should be aware of the catabolic phases of acute TBI events indicating notable protein loss in the patients. Therefore, we should consider the additional supply of protein when managing TBI patients.

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Current status of the association between malnutrition defined by the GLIM criteria and postoperative outcomes in gastrointestinal surgery for cancer: a narrative review

Cited by 12 publications

References 47 publications

Surgical Prehabilitation in Patients with Gastrointestinal Cancers: Impact of Unimodal and Multimodal Programs on Postoperative Outcomes and Prospects for New Therapeutic Strategies—A Systematic Review

Surgical Prehabilitation in Patients with Gastrointestinal Cancers: Impact of Unimodal and Multimodal Programs on Postoperative Outcomes and Prospects for New Therapeutic Strategies—A Systematic Review

Significance of malnutrition defined with Global Leadership Initiative on Malnutrition criteria in patients with hepatocellular carcinoma after hepatic resection

Analysis of Nitrogen Balance Test in Patients With Traumatic Brain Injury

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