Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects

Botezan, Sara; Baci, Gabriela-Maria; Bagameri, Lilla; Pașca, Claudia; Dezmirean, Daniel Severus

doi:10.3390/molecules28031510

Cited by 33 publications

(27 citation statements)

References 121 publications

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“…MRJ1-9 present a wide range of functions, including anti-in ammatory effects (MRJ1, MRJ2, and MRJ3), antitumor (MRJPs), anti-fungal (MRJ1), antiviral (MRJ1), antioxidant effects (MRJ2), anti-allergic and anti-in ammatory activities (MRJ3) [12]. Synthetic peptides derived from conserved tandem pentapeptide repeats found at the C-terminal region MRJ3, and in most MRJ proteins, reduced the expression of TNF-a and IL-6 from activated macrophage cells (THP1) [14].…”

Section: Major Royal Jelly Proteins In Propolismentioning

confidence: 99%

First proteome analysis of poplar-type propolis

Šuran,

Radić,

Silva

et al. 2023

Preprint

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Propolis is a natural mixture of honeybee-released and plant-derived compounds produced by honeybees. Poplar propolis is rich in bioactive polyphenolic compounds, and due to its many health benefits, it is commonly used as a food supplement or functional food ingredient. However, it is the only honeybee product whose proteome hasn’t been analyzed. Here, we report a first proteome analysis of poplar-type propolis, a challenging glue-type resinous sample for protein characterization. Raw propolis mixture was precipitated with cold acetone to obtain the protein fraction. Proteins were digested with trypsin, and generated peptides were analyzed on nano-ESI-qTOF SYNAPT G2-Si mass spectrometer (MS) by data-independent acquisition (DIA) and data-dependent acquisition (DDA). Identified peptides and inferred proteins suggest the presence of new bioactive molecules as components of propolis. The poplar-type propolis proteome is composed of a mixture of proteins from Apis and Populus genera. This is the first-ever report of the proteome of any type of propolis.

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Section: Major Royal Jelly Proteins In Propolismentioning

confidence: 99%

First proteome analysis of poplar-type propolis

Šuran,

Radić,

Silva

et al. 2023

Preprint

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“…Royal jelly is a substance secreted by the hypopharyngeal and mandibular glands of bees and represents an important nutraceutical, a functional food as well as an oral food supplement (OFS) [ 34 ]. A bioactive substance of royal jelly called 10-hydroxy-2decenoic acid (10-HDA) plays a major role in several biological processes, including inflammation and oxidative stress [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients

Noce,

Marrone,

Di Lauro

et al. 2024

Pharmaceuticals

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Long coronavirus disease (COVID) syndrome leads to chronic inflammatory state onset that can have a multisystem impact and compromise organ function. Moreover, long COVID syndrome is often characterized by the presence of chronic fatigue, which affects subjects’ daily activities and worsens their quality of life. The aim of our double-blind, placebo-controlled randomized trial (protocol code RS 150.21, approved on 4 November 2021) was to evaluate the beneficial effects of the consumption of 2 cps/day, for two months, of an oral food supplement (OFS), based on Echinacea angustifolia, rosehip, propolis, royal jelly and zinc, in long COVID patients, compared to a two-month placebo period. The OFS’s vitamin C content was equal to 22.17 mg/g (8.87 mg/capsule). The OFS’s total polyphenol content was 43.98 mg/g gallic acid equivalents. At the end of the in vivo study, we highlighted a significant decrease in the inflammatory parameters in the OFS period, compared to the placebo period (neutrophil-to-lymphocyte ratio, p = 0.0455; monocyte to-lymphocyte ratio, p = 0.0005; C-reactive protein, p = 0.0145). Our study also highlighted a significant increase in vitamin D serum values (p = 0.0005) and, at the same time, an improvement in patients’ life quality and a reduction in fatigue, monitored by the fatigue severity scale. This study showed the OFS’s beneficial effects on the inflammatory state, fatigue and quality of life in long COVID patients.

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“…[ 1 ] MRJP’s present in RJ provide antimicrobial efficacy against various bacteria. [ 2 ] The antimicrobial activity of RJ against Enterococcus faecalis can be attributed to the presence of MRJP1,[ 3 ] while its effectiveness against Staphylococcus aureus is primarily due to the presence of 10-hydroxy-2-decenoic acid (10-HDA). [ 4 5 ] In addition, its antifungal activity against Candida albicans is associated with the presence of MRJP2.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of minimum inhibitory concentration and minimum bactericidal concentration of royal jelly against Enterococcus faecalis, Staphylococcus aureus, and Candida albicans

Mahale,

Sharma

2024

Journal of Conservative Dentistry and Endodontics

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Objective: The objective of this study was to ascertain the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of royal jelly (RJ) against three microorganisms frequently linked with endodontic infections: Staphylococcus aureus, Enterococcus faecalis, and Candida albicans. Materials and Methods: Freshly harvested RJ was prepared at different concentrations (20%, 10%, 5%, 2.5%, and 1.25%) in distilled water. The microbial cultures of the target organisms were prepared. MIC was determined using a broth dilution technique, monitoring microbial growth. MBC was determined by inoculating agar plates with samples from tubes showing no apparent growth and evaluating the presence of bacterial or fungal growth following the incubation period. Results: For S. aureus, the MIC and MBC were 5 mg/ml of RJ. For E. faecalis, the MIC and MBC were 10 mg/ml of RJ. For C. albicans, both MIC and MBC were 10 mg/ml of RJ. The findings demonstrated RJ’s potential to inhibit and eliminate these pathogenic microorganisms, making it a potential candidate for endodontic infection control. Conclusion: The antimicrobial properties of RJ against S. aureus, E. faecalis, and C. albicans present a promising avenue for enhancing infection control in endodontics. Additional investigations are needed to refine its use in clinical settings, especially in cases with mixed microbial infections.

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Current Status of the Bioactive Properties of Royal Jelly: A Comprehensive Review with a Focus on Its Anticancer, Anti-Inflammatory, and Antioxidant Effects

Cited by 33 publications

References 121 publications

First proteome analysis of poplar-type propolis

First proteome analysis of poplar-type propolis

Potential Anti-Inflammatory and Anti-Fatigue Effects of an Oral Food Supplement in Long COVID Patients

Evaluation of minimum inhibitory concentration and minimum bactericidal concentration of royal jelly against Enterococcus faecalis, Staphylococcus aureus, and Candida albicans

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