Current status of ventilation-perfusion imaging

Neuman, Ronald D.; Sostman, H.D.; Gottschalk, Alexander

doi:10.1016/s0001-2998(80)80002-x

Cited by 79 publications

(19 citation statements)

References 47 publications

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“…For example, when a lung scan is performed, radiolabelled particles of albumin or other microspheres of between 8±50 mm in size are injected, so as to occlude between 1±5% of the pulmonary vasculature. These particles are removed into the lymphatic system in the course of 8±24 h. This procedure is remarkably safe, in the 40 yrs during which it has been employed there have been no reports of chronic PH [64]. Miliary thrombotic embolism also seems to be a relatively benign event.…”

Section: Do Recurrent Episodes Of Major Pulmonary Embolism Cause Chromentioning

confidence: 99%

Is pulmonary embolism a common cause of chronic pulmonary hypertension? Limitations of the embolic hypothesis

Egermayer¹,

Peacock²

2000

Eur Respir J

151

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Is pulmonary embolism a common cause of chronic pulmonary hypertension? Limitations of the embolic hypothesis. P Egermayer, A.J. Peacock. #ERS Journals Ltd 2000. ABSTRACT: The hypothesis that chronic thromboembolic pulmonary hypertension results from unresolved pulmonary embolism has strongly influenced the diagnosis and management of this disease since the 1960s. However, it is nearly impossible to induce chronic pulmonary hypertension in any animal species by means of repeated embolization of thrombotic material. The haemodynamic effects of thrombotic pulmonary embolism of different degrees of magnitude have also been studied in humans and there is little to suggest that chronic pulmonary hypertension is a likely long term outcome. Furthermore many conditions which predispose to venous thromboembolism do not appear to cause thromboembolic pulmonary hypertension. Other arteriopathic and atherosclerotic risk factors, are found in patients with chronic thromboembolic pulmonary hypertension, but not in those with venous thrombosis, suggesting that these may be unrelated conditions.Thrombosis in situ of the pulmonary arteries is common in severe pulmonary hypertension of any cause. Such thrombosis cannot usually be distinguished from pulmonary embolism. It is hypothesized that in situ thrombosis and pulmonary arteriopathy are common causes of vascular occlusion which is usually diagnosed as "chronic thromboembolic pulmonary hypertension" and that venous thromboembolism is unlikely to be a common cause of chronic pulmonary hypertension. It is further hypothesized that pulmonary embolism is seldom the sole cause of "chronic thromboembolic pulmonary hypertension". Eur Respir J 2000; 15: 440±448.

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Section: Do Recurrent Episodes Of Major Pulmonary Embolism Cause Chromentioning

confidence: 99%

Is pulmonary embolism a common cause of chronic pulmonary hypertension? Limitations of the embolic hypothesis

Egermayer¹,

Peacock²

2000

Eur Respir J

151

View full text Add to dashboard Cite

show abstract

“…Portanto, o estudo da perfusão pulmonar é capaz de promover informações diagnósticas por representar visualmente a distribuição relativa do fluxo sangüíneo arterial pulmonar no momento seguinte à injeção do radiofármaco (MOSER, 1977;NEUMANN et al, 1980).…”

Section: Aspectos Técnicos Da Cintilografiaunclassified

“…(NEUMANN et al, 1980). O número de vasos obstruídos temporariamente pelas esferas de macroagregado injetadas é pequeno em relação ao número total de capilares pulmonares, não produzindo efeitos hemodinâmicos significativos (NEUMANN et al, 1980;GILLETTE, 1971). O material utilizado é degradado em pequenas partículas que deixam a vasculatura pulmonar, com uma meia-vida de 6 a 8 horas, e os produtos dessa quebra são fagocitados pelas células do sistema reticuloendotelial.…”

Section: Aspectos Técnicos Da Cintilografiaunclassified

“…O material utilizado é degradado em pequenas partículas que deixam a vasculatura pulmonar, com uma meia-vida de 6 a 8 horas, e os produtos dessa quebra são fagocitados pelas células do sistema reticuloendotelial. (NEUMANN et al, 1980 MARTIN, 1987;NEUMANN et al, 1980). É importante que não haja refluxo sangüíneo durante a administração do macroagregado de albumina, uma vez que a formação de coágulos dentro da seringa pode resultar em absorção heterogênea do radiofármaco e simular "pontos quentes" na imagem da perfusão (HECK; DULEY, 1974;NEUMANN et al, 1980).…”

Section: Aspectos Técnicos Da Cintilografiaunclassified

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