Current status of β-lactam antibiotic use and characterization of β-lactam-resistant Escherichia coli from commercial farms by integrated broiler chicken operations in Korea

Jung, Hye-Ri; Lee, Yu Jin; Hong, Serim; Yoon, Sunghyun; Lim, Suk-Kyung; Lee, Young Ju

doi:10.1016/j.psj.2023.103091

Cited by 2 publications

(1 citation statement)

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“…Notably, fluoroquinolones and cephalosporins have been prominently utilized for treating Salmonella infections [ 7 ]. Simultaneously, there has been a discernible increase in the application of beta-lactam antibiotics for treating Salmonella infections [ 8 ]. This heightened usage can exert a selective pressure conducive to the proliferation of extended-spectrum beta-lactamase (ESBL) bacteria [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Genetic Characteristics of Extended-Spectrum Beta-Lactamase-Producing Salmonella Isolated from Retail Meats in South Korea

Kang,

Kim,

Kim

et al. 2024

J. Microbiol. Biotechnol.

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Earlier studies have validated the isolation of extended-spectrum beta-lactamase-producing Salmonella (ESBL-Sal) strains from food. While poultry is recognized as a reservoir for Salmonella contamination, pertinent data regarding ESBL-Sal remains limited. Consequently, the Ministry of Food and Drug Safety has isolated Salmonella spp. from retail meat and evaluated their antibiotic susceptibility and genetic characteristics via whole-genome sequencing. To further elucidate these aspects, this study investigates the prevalence, antibiotic resistance profiles, genomic characteristics, and homology of ESBL-Sal spp. obtained from livestock-derived products in South Korean retail outlets. A total of 653 Salmonella spp. were isolated from 1,876 meat samples, including 509 beef, 503 pork, 555 chicken, and 309 duck samples. The prevalence rates of Salmonella were 0.0%, 1.4%, 17.5%, and 28.2% in the beef, pork, chicken, and duck samples, respectively. ESBL-Sal was exclusively identified in poultry meat, with a prevalence of 1.4% in the chicken samples (8/555) and 0.3% in the duck samples (1/309). All ESBL-Sal strains carried the bla CTX-M-1 gene and exhibited resistance to ampicillin, ceftiofur, ceftazidime, nalidixic acid, and tetracycline. Eight ESBL-Sal isolates were identified as S. Enteritidis with sequence type (ST) 11. The major plasmid replicons of the Enteritidis-ST11 strains were IncFIB(S) and IncFII(S), carrying antimicrobial resistance genes (β-lactam, tetracycline, and aminoglycoside) and 166 virulence factor genes. The results of this study provide valuable insights for the surveillance and monitoring of ESBL-Sal in South Korean food chain.

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Section: Introductionmentioning

confidence: 99%