Current strategies against invasive fungal infections in patients with aplastic anemia, strong power and weak weapon, a case report and review of literature

Zekavat, Omid Reza; Amanati, Ali; Fazl, Saleh; Abdolkarimi, Babak; Fathpour, Gholamreza; Badiee, Parisa; Geramizadeh, Bita

doi:10.1016/j.mmcr.2016.03.003

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…Previous research has reported that iron deficiency causes calcium overload and increased intracellular accumulation of reactive oxygen species (ROS), thereby leading to disturbed ion homeostasis and finally suppressing fungal growth [ 24 ]. However, aplastic anemia patients were proven to have an increased prevalence of fungal infections [ 25 ]. However, the present study result was contradictory to this observation since 53.5% of our study population had a history of anemia.…”

Section: Discussionmentioning

confidence: 99%

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Devi,

Kizhakkoottu

2024

Cureus

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Introduction Most fungal infections are responsive to antifungal therapy. However, failure to diagnose the same can significantly affect the quality of lives of patients. Timely identification of fungal infections and their association with varied demographic and clinical parameters will help in improving the prognosis of the patient. The present study aims to evaluate the prevalence of fungal infections among various age groups and genders and also to evaluate the association of fungal infections with demographic parameters. Methods This study included a sample size of n = 600. The demographic and clinical details were compiled and transferred to IBM SPSS Version 23 software (IBM Corp., Armonk, NY) for statistical analysis. Descriptive and Pearson chi-square tests were used to analyze the association of the type of fungal infection with gender, age, and comorbidities. A p-value of less than 0.05 is considered statistically significant. Results Angular cheilitis (40%, 240), followed by denture stomatitis (37.5%, 225), were the most common type of fungal infection among the sample population, and the elderly age group (51-72 years) was the most affected. Angular cheilitis was the most common infection among both males (21.4%, 128) and females (18.6%, 112), but candidiasis was reported more in females (18%, 108) than males (3%, 18) (p = 0.00). Angular cheilitis (32%, 192) and candidiasis (18%, 108) were more observed in association with anemia; however, denture stomatitis (34%, 204) was significantly higher among diabetics (p = 0.00). Conclusion The identification of associated systemic and demographic factors is as important as the treatment of fungal infection itself. The recognition of fungal infections and the role of parameters like age, gender, and systemic comorbidities in the development of fungal infections will have valuable implications for public health. Future research is required for a clear understanding of the same.

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Section: Discussionmentioning

confidence: 99%

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Devi,

Kizhakkoottu

2024

Cureus

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“…Therefore, the necrotic tissues that preclude the sufficient delivery and penetration of the antifungals into the affected area may have led to further invasion to the periorbital and neurovasculature areas resulting in death. Antifungal prophylaxis is recommended for the prevention of invasive fungal infection in pre-transplant period; however, it remains uncertain for other high-risk groups [23].…”

Section: Discussionmentioning

confidence: 99%

Fatal rhinocerebral mucormycosis in a patient with ulcerative colitis receiving azathioprine and corticosteroid

Najafi¹,

Kermani²,

Ghadi³

et al. 2019

CMM

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Background and Purpose: Rhinocerebral mucormycosis is a rare fatal fungal infectionwhich is on a growing trend, particularly among immunocompromised patients.Immunosuppressive drugs, including corticosteroids and antimetabolites, increase therisk of this infection. Herein, we reported the case of fulminant rhinocerebralmucormycosis in a patient with ulcerative colitis receiving azathioprine andcorticosteroid.Case report: A 58-year-old woman was admitted to the hospital in a state of coma withan extensive necrosis in her nose. She was afflicted with intestinal bleeding after 1month of fasting and was treated with azathioprine and a high dose of prednisolone forulcerative colitis 2 months prior to hospital admission. The direct microscopicexamination of the necrotic tissues of the paranasal sinuses showed several non-septatehyphae consistent with Mucorales. Culture media yielded Rhizopus species, which wasidentified as Rhizopus oryzae by internal transcribed spacer polymerase chain reactionsequencing. Despite the implementation of surgical and pharmaceutical (liposomalamphotericin B) treatments, the patient expired after 2 weeks of admission.Conclusion: The gastroenterologists should be aware of the adverse effect ofimmunosuppressive drugs they prescribe for the treatment of inflammatory boweldisease.

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Long-term results of allogeneic peripheral blood hematopoietic stem cell transplantation for severe aplastic anemia

Aladağ

Göker

Demiroǧlu

et al. 2021

Transfusion and Apheresis Science

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Current strategies against invasive fungal infections in patients with aplastic anemia, strong power and weak weapon, a case report and review of literature

Cited by 3 publications

References 19 publications

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Clinico-Demographic Parameters of Oral Fungal Infections: An Institutional Retrospective Study

Fatal rhinocerebral mucormycosis in a patient with ulcerative colitis receiving azathioprine and corticosteroid

Long-term results of allogeneic peripheral blood hematopoietic stem cell transplantation for severe aplastic anemia

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