Current strategies in inhibiting biofilm formation for combating urinary tract infections: Special focus on peptides, nano-particles and phytochemicals

Bharadwaj, Kaushik Kumar; Rabha, Bijuli; Choudhury, Bhabesh Kumar; Rosalin, Rosina; Sarkar, Tanmay; Baishya, Debabrat; Chanu, Naorem Bidyaleima; Singh, Yengkhom Disco; Panda, Manasa Kumar; Pati, Siddhartha

doi:10.1016/j.bcab.2021.102209

Cited by 14 publications

(8 citation statements)

References 129 publications

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“…Good in vivo Gram-selective antibacterial properties have been demonstrated by treating wound mouse models with these AMP hydrogels; the results suggest that the hydrogels promote wound healing. We believe that these Gram-selective AMP hydrogels could have potentially important applications in treating common recurring infections such as urinary tract infections, [62][63][64] abscesses, [65][66][67] or skin and soft tissue infections, [68][69][70] as well as other non-lifethreatening infections.…”

Section: Introductionmentioning

confidence: 99%

Gram-selective antibacterial peptide hydrogels

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Gram-selective antibacterial peptide hydrogels

et al. 2022

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“…To fully develop and understand such approaches, we need to know more about the molecular mechanisms involved in the interactions of host-pathogen since several important pathogen-associated systems may remain unknown. Moreover, a rapid and early diagnosis of the infections and their causative agents need to be effective so that pathogenic blockers may be administered at an early infection stage [ 105 , 106 ]. Natural anti-biofilm compounds can be administered in cases of diseases and surgeries, where there exist chances of developing untraceable infections on dental, bone, breast implants, and eye lenses.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Phytocompound Mediated Blockage of Quorum Sensing Cascade in ESKAPE Pathogens

et al. 2022

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Increased resistance of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter sp. (ESKAPE) pathogens against various drugs has enhanced the urge for the development of alternate therapeutics. Quorum sensing (QS) is a density dependent cell-to-cell communication mechanism responsible for controlling pathogenicity with the regulation of gene expression. Thus, QS is considered a potential target for the development of newer anti-biofilm agents that do not depend on the utilization of antibiotics. Compounds with anti-QS effects are known as QS inhibitors (QSIs), and they can inhibit the QS mechanism that forms the major form in the development of bacterial pathogenesis. A diverse array of natural compounds provides a plethora of anti-QS effects. Over recent years, these natural compounds have gained importance as new strategies for combating the ESKAPE pathogens and inhibiting the genes involved in QS. Different pharmacognostical and pharmacological studies have been carried out so far for identification of novel drugs or for the discovery of their unique structures that may help in developing more effective anti-biofilm therapies. The main objective of this review is to discuss the various natural compounds, so far identified and their employed mechanisms in hindering the genes responsible for QS leading to bacterial pathogenesis.

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“…SM’s also called phytochemicals include phenolic, flavonoids, tannins, and others. These important natural chemicals have been widely reported to have biological effects that are important for drug manufacturing ( Kabir et al, 2016 , Maher et al, 2021a , Maher et al, 2021b , Hazra et al, 2020 , Bharadwaj et al, 2021a , Bharadwaj et al, 2021b , Bharadwaj et al, 2021c ). In recent times, treating disease using plant-derived products has gained significant attention worldwide due to several reasons, including efficacy, availability, affordability, considered fewer/no side effects ( Mintah et al, 2019 , Abdulhafiz et al, 2020a , Mohammadi et al, 2020 , Mohammadi et al, 2022 , Roumeliotis et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%