Current Studies on Oxidant Stress in Dialysis

Abstract

Breath ethane measurements in hemodialysis indicate that a portion of these patients suffer increased oxidant stress, consistent with findings using other methods for oxidant stress determination. Loosely-bound iron definitely appears in the bloodstream when substantial doses of IV iron are administered, since transferrin is fully saturated, but our investigations generally do not show short-term oxidant stress from this treatment. If small doses of IV iron are utilized, transferrin saturation can be avoided, and risk is minimized. The vitamin C status of hemodialysis patients is usually lower than the general population, and the impact of this deficiency must be assessed in controlled investigations. Various interventions, including the vitamin E-bonded dialyzer and dietary antioxidant supplements, may ameliorate a portion of the oxidant stress in hemodialysis patients.

Exertion in Kangoo Jumps Aerobic: Evaluation and Interpretation Using Spectroscopic Technique Determinations

“…Ethylene from the human breath is an indicator of oxidant stress and can be directly correlated to physiological events in the patients (or biochemical events surrounding lipid peroxidation) [16].…”

The kidney disease wasting: Inflammation, oxidative stress, and diet‐gene interaction

“…It is an important step in inflammation and tissue repair processes 41 . However, an improper or maladaptive activation of oxidative processes may be chronically present in pathological situations, such as uremia, contributing to chronic cell and tissue injury 42,43 …”

“…In MHD patients, the balance between pro‐oxidant and anti‐oxidant capacity appears shifted toward an increased SOX 42 . Blood levels of several lipid and protein oxidation products such as F2 isoprostanes are increased in MHD patients 44,45 .…”

“…41 However, an improper or maladaptive activation of oxidative processes may be chronically present in pathological situations, such as uremia, contributing to chronic cell and tissue injury. 42,43 In MHD patients, the balance between pro-oxidant and anti-oxidant capacity appears shifted toward an increased SOX. 42 Blood levels of several lipid and protein oxidation products such as F2 isoprostanes are increased in MHD patients.…”

“…42,43 In MHD patients, the balance between pro-oxidant and anti-oxidant capacity appears shifted toward an increased SOX. 42 Blood levels of several lipid and protein oxidation products such as F2 isoprostanes are increased in MHD patients. 44,45 Neutrophils of MHD patients overproduce reactive oxygen species (ROS) in response to activating stimuli.…”