Current Technical Issues for Surgery of Primary Liver Cancer

Abstract

Primary liver cancer is the fifth most common cancer worldwide. Apart from liver transplantation, surgical resection has been accepted as the effective local treatment for hepatocellular carcinoma (HCC), one of the most common primary liver cancers. Recent technological innovations including navigation technology and intraoperative real-time fluorescence guidance have been utilized for liver resections in clinical practice. With respect to liver resection techniques, the laparoscopic approach has been increasingly gaining popularity as one of the minimally-invasive treatments of HCC. These technological innovations and technical advancements are expected to further improve the safety and efficacy of liver resections.

Ex vivo liver resection and autotransplantation with cardiopulmonary bypass for hepatoblastoma in children: A case report

“…Alternatively, chemotherapy and other comprehensive treatments are available to reduce the tumor size before surgical resection. 8 can be achieved with this procedure. 12 In addition, extracorporeal circulation combined with hypothermic perfusion can greatly prolong the operation time and provide sufficient conditions for complex tumor resection and liver vascular reconstruction.…”

“…For children with a preoperative imaging diagnosis of a stage one HB tumor, we select to remove the hepatic lobe via complete resection. Alternatively, chemotherapy and other comprehensive treatments are available to reduce the tumor size before surgical resection . However, even if the patient has received several rounds of chemotherapy, the tumor cannot be removed in a conventional manner.…”

Establishment of an insufficient radiofrequency ablation orthotopic nude mouse model of hepatocellular carcinoma to study the invasiveness and metastatic potential of residual cancer

“…Insufficient RFA reduces tumor volume and prolongs survival time in nude mice. The tumor volume of the HCCLM3-GFP-derived xenografts was 449.58±350.75 mm 3 in the insufficient RFA group, which was significantly smaller compared with that of the matched sham-operated controls (1788.66±608.80 mm 3 ; P<0.05; Fig. 3A).…”

“…Primary liver cancer is the fifth most common type of cancer and the third leading cause of cancer-related mortality worldwide, with hepatocellular carcinoma (HCC) accounting for >90% of cases (1). Although surgical resection is the standard treatment modality for HCC, its use is limited, as the majority of patients, even in those with small-sized tumors, also have associated severe liver dysfunction (2,3). Liver transplantation provides an alternative curative treatment for small unresectable HCC in patients with small-sized tumors.…”

RNA sequencing analysis reveals the competing endogenous RNAs interplay in resected liver cancer patients who received interferon-alpha therapy

“…Hepatocellular carcinoma (HCC), one of the most serious malignancies, is highly prevalent in China [1]. Although surgery is one of the curative-intent options to patients with early-stage disease, the high recurrence rate (50% at 3 years and 70% at 5 years) greatly reduces the effectiveness of this method [2][3][4]. Thus, adjuvant therapy is increasing attractive and becomes the research focus.…”