2022
DOI: 10.1002/anbr.202200040
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Current Technological Trends in Transdermal Biosensing

Abstract: Transdermal biosensing focuses on the qualitative and quantitative collection and detection of biomarkers on and in the skin layers. In comparison to the blood‐based diagnosis, transdermal sensing technologies provide pain‐free, convenient, patient‐friendly, and infection‐avoiding methods to collect biosignals from transdermal samples such as interstitial fluid (ISF) and sweat. This article summarizes the latest trends in transdermal biosensing including the technologies and their application blueprints. Speci… Show more

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Cited by 11 publications
(4 citation statements)
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“…8 In the past decade, significant research advances have been made to address the challenges of using microneedles to extract skin interstitial fluid and analyze the biomarkers present in the fluid. 9 For example, Kollure et al reported a two-component MN system that was composed of a filter paper backing and a stainless-steel MN array. 10 By inserting the MN into the skin, the sharp tip of the MN generated micropores on the skin surface, through which the skin ISF flew out of the skin and was collected by the paper backing.…”
Section: Introductionmentioning
confidence: 99%
“…8 In the past decade, significant research advances have been made to address the challenges of using microneedles to extract skin interstitial fluid and analyze the biomarkers present in the fluid. 9 For example, Kollure et al reported a two-component MN system that was composed of a filter paper backing and a stainless-steel MN array. 10 By inserting the MN into the skin, the sharp tip of the MN generated micropores on the skin surface, through which the skin ISF flew out of the skin and was collected by the paper backing.…”
Section: Introductionmentioning
confidence: 99%
“…Based on this account, extensive attention and research have been devoted to portable ISF-based electrochemical glucose biosensors and noninvasive ISF extraction techniques. 16 For instance, Bandodkar et al have performed a proof-of-concept study for noninvasive ISF glucose monitoring using the reverse iontophoresis (RI) technique. 7 In this respect, RI, which employs a mild constant current to generate electroosmosis from the anode to cathode and then noninvasively extracts glucose molecules onto the skin surface, 17 is the most prevalent technique while its microscale extraction flux of ISF could result in inaccurate precision.…”
Section: Introductionmentioning
confidence: 99%
“…6,7 When integrated with biosensors, MNs are capable of detecting and quantifying metabolites, electrolytes and other clinically relevant targets. 8,9 When we apply MNs-based biosensing systems for detection of metabolites (such as glucose and alcohol), it avoids the painful blood sampling in conventional techniques and establishes a convenient and accurate detection method. For example, Wang's group has been devoted to developing MN-based biosensing system for various biomarkers, such as glucose, 10 alcohol, 11 lactate, levodopa, 12 opioid, and organophosphate nerve agents.…”
Section: Introductionmentioning
confidence: 99%
“…One attractive platform for skin ISF collection is the microneedle (MN) technology due to its minimal invasiveness and versatility 6,7 . When integrated with biosensors, MNs are capable of detecting and quantifying metabolites, electrolytes and other clinically relevant targets 8,9 . When we apply MNs‐based biosensing systems for detection of metabolites (such as glucose and alcohol), it avoids the painful blood sampling in conventional techniques and establishes a convenient and accurate detection method.…”
Section: Introductionmentioning
confidence: 99%