Current Treatment for Hepatocellular Carcinoma

Cahill, Bridget A.; Braccia, Deborah

doi:10.1188/04.cjon.393-399

Cited by 29 publications

(26 citation statements)

References 55 publications

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“…Although chemotherapy, hepatectomy, and liver transplantation are representative treatments for HCC, these treatments have a limited range of applications [2]. Over the last several decades, the common treatment of liver cancer is suboptimal and the prognosis of patients is poor [3].…”

Section: Introductionmentioning

confidence: 99%

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis by suppression angiogenesis

Liu

Zhang

et al. 2015

International Journal of Biological Macromolecules

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Section: Introductionmentioning

confidence: 99%

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis by suppression angiogenesis

Liu

Zhang

et al. 2015

International Journal of Biological Macromolecules

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“…Introduction hepatocellular carcinoma (hcc) is associated with a dismal patient outcome, and its incidence rate continues to rise (1).…”

mentioning

confidence: 99%

Up-regulation of microRNAs, miR21 and miR23a in human liver cancer cells treated with Coptidis rhizoma aqueous extract

Zhu¹,

Wang²,

Tsao³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. Coptidis rhizoma (cr; huanglian in chinese) has been used for the treatment of cancer in chinese medicine, and recent studies have supported its use in cancer therapy. micrornas (mirnas) play an important role in the pathophysiology of human cancers. We examined alterations in the miRNA profile of hepatocellular carcinoma (HCC) cells after treatment with Coptidis rhizoma aqueous extract (craE). an on-chip microarray method was used to detect alterations in the expression profile of miRNAs in human hcc mhcc97-l cells after exposure to 175 µg/ml craE. altered expression of several mirnas was detected in the mhcc97-l cells after treatment with 175 µg/ml craE. the microarray results were validated by quantitative real-time pcr (qrt-pcr). consistent results were obtained; qrt-pcr confirmed that both miR-21 and miR-23a were significantly up-regulated. targetScan and pictar microrna databases were used to predict the possible target genes of the altered mirnas. the results showed that the altered mirnas after craE treatment may serve as markers for the therapy of liver cancer. To the best of our knowledge, this is the first report on the up-regulation of mirnas, mir21 and mir23a in human liver cancer cells treated with craE. Our results suggest that craE targets mir-21 and mir-23a in liver cancer cells supporting the potential application of craE in the treatment of hcc.Introduction hepatocellular carcinoma (hcc) is associated with a dismal patient outcome, and its incidence rate continues to rise (1).at present, only 10-20% of patients with hcc are eligible for surgical therapy (2). the results of therapeutic treatment for liver cancer remain unsatisfactory. micrornas (mirnas) are single-stranded rna molecules, approximately 21-23 nucleotides in length, which are able to regulate gene expression at either the transcriptional or post-transcriptional level. mirnas are encoded by genes that are transcribed from dna, but are not translated into protein.This type of non-coding RNA was first described in 1993 by lee et al (3), which was later referred to as microrna (4). Subsequent studies in recent years have demonstrated a significant difference in miRNA expression profiles in human malignancies, including chronic lymphocytic leukaemia, pediatric Burkitt's lymphoma, gastric cancer, lung cancer and large-cell lymphoma. These findings suggest that miRNAs may play an important role in carcinogenesis as a novel class of oncogenes or tumor-suppressor genes (5,6). thus, mirnas have been considered as novel targets for cancer therapy.Coptidis rhizoma (cr) has been used in chinese medicine for thousands of years. previous studies have demonstrated that cr exhibits a variety of pharmacological actions, including anti-neoplastic, anti-oxidative, anti-bacterial, anti-viral, antiinflammatory, anti-hyperglycemic, anti-hypertensive and liver protective effects (7-9). the anti-tumor action of cr has been extensively reported. cr induces multiple signal transduction pathways to promote cancer cell apoptosis, inhibiting tumor ce...

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“…But many patients could not be treated surgically when diagnosis was made too late. Chemotherapy becomes the important treatment for liver cancer [6,7] . 5-FU is used extensively in the chemotherapy of hepatocellular carcinoma [8,9] .…”

Section: Discussionmentioning

confidence: 99%

Effects of endogenous nitric oxide induced by 5-fluorouracil and L-Arg on liver carcinoma in nude mice

Yin¹,

Jiang²,

Liu³

et al. 2007

WJG

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density of iNOS, iNOS activity and NO concentration are 31.693, 21.949, and 33.909, respectively, P < 0.05. The concentration of NO was related to the expression of P16 and BAX. The correlation coefficient was 0.764 and 0.554. CONCLUSION:5-FU combined with L-Arg can inhibit the growth of tumor in nude mice. The effect may be related to inducing the synthesis and increasing the activity of iNOS. The production of NO is increased, and it can enhance the expression of apoptosis-related gene and antioncogene. INTRODUCTIONOver the past decade or so, it has become evident that free radical gas nitric oxide acts as a novel transcellular messenger molecule in many key physiological and pathological processes. It appears that high levels of nitric oxide (NO) may be cytostatic or cytotoxic for tumor cells [1,2] . NO is a small gaseous molecule generated in a wide variety of cells as a product of the conversion of L-arginine into L-citrulline by the enzyme nitric oxide synthase (NOS). There have been few reports about the antitumor effects of endogenous nitric oxide in vivo [3,4] . In this study, we observed the inductive effects of 5-fluorouracil (5-FU) and L-arginine (L-Arg) on the endogenous nitic oxide in the human live carcinoma model in nude mice and proved the antitumor effects of the endogenous nitric oxide in the primary hepatic carcinoma and found effective adjuvant for 5-FU. The necrotic range and apoptosis index were significantly increased after the drug injection. The necrotic range was biggest in 5-FU + L-Arg group (χ 2 = 15.963, P < 0.05). MATERIALS AND METHODS MaterialsThe apoptosis indexes were as follows: NS, 17.4% ± 6.19%; 5-FU, 31.3% ± 12.3%; and 5-FU + L-Arg, 46%± 15.24% (P < 0.05, 5-FU vs 5-FU + L-Arg; P < 0.05, NS vs 5-FU + L-Arg; P < 0.05, NS vs 5-FU). The expression and activity of iNOS were increased in the tumor tissue.

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Current Treatment for Hepatocellular Carcinoma

Cited by 29 publications

References 55 publications

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis by suppression angiogenesis

A Huaier polysaccharide restrains hepatocellular carcinoma growth and metastasis by suppression angiogenesis

Up-regulation of microRNAs, miR21 and miR23a in human liver cancer cells treated with Coptidis rhizoma aqueous extract

Effects of endogenous nitric oxide induced by 5-fluorouracil and L-Arg on liver carcinoma in nude mice

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