Current treatments for axillary hyperhidrosis

Fitzgerald, Éilís; Feeley, T. M.; Tierney, Sean

doi:10.1016/s1479-666x(04)80028-3

Cited by 15 publications

(11 citation statements)

References 47 publications

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“…Seven BoNT serotypes are known to exist (A-G), all of which are produced by strains of the bacterium Clostridium botulinum. BoNT causes the paralytic syndrome botulism, but also holds therapeutic application in the treatment of dystonias [3][4][5][6], spasticity [7,8], facial rhytides [9], axillary hyperhidrosis [10,11], and some pain syndromes [12,13].…”

Section: Introductionmentioning

confidence: 99%

Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection

et al. 2008

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Botulinum neurotoxin (BoNT) injection into the thyroarytenoid (TA) muscle is a commonly performed medical intervention for adductor spasmodic dysphonia. The mechanism of action of BoNT at the neuromuscular junction is well understood, however, aside from reports focused on myosin heavy chain isoform abundance, there is a paucity of data addressing the effects of therapeutic BoNT injection on the TA muscle proteome. In this study, 12 adult Sprague Dawley rats underwent unilateral TA muscle BoNT serotype A injection followed by tissue harvest at 72 hrs, 7 days, 14 days, and 56 days post-injection. Three additional rats were reserved as controls. Proteomic analysis was performed using 2D SDS-PAGE followed by MALDI-MS. Vocal fold movement was significantly reduced by 72 hrs, with complete return of function by 56 days. Twenty-five protein spots demonstrated significant protein abundance changes following BoNT injection, and were associated with alterations in energy metabolism, muscle contractile function, cellular stress response, transcription, translation, and cell proliferation. A number of protein abundance changes persisted beyond the return of gross physiologic TA function. These findings represent the first report of BoNT induced changes in any skeletal muscle proteome, and reinforce the utility of applying proteomic tools to the study of system-wide biological processes in normal and perturbed TA muscle function.

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Section: Introductionmentioning

confidence: 99%

Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection

et al. 2008

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“…Botulinum toxin A is increasingly used to treat patients with axillary hyperhidrosis 5 . It usually induces a complete, but temporary, anhidrosis so patients need to have injections at regular intervals.…”

Section: Discussionmentioning

confidence: 99%

Topical local anaesthetic (tetracaine) reduces pain from botulinum toxin injections for axillary hyperhidrosis

O’Riordan

Fitzgerald

Gowing

et al. 2006

British Journal of Surgery

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“…9 Diagnosis and clinical presentation Hyperhidrosis may be primary or secondary; the former is relatively common, affecting between 0.6% and 1% of the general population. 10,11 Primary or focal hyperhidrosis is found to start during adolescence or even before and seems to be inherited as anautosomal dominant genetic trait. The palms, soles and axillae are the most commonly affected sites.…”

Section: Pathophysiologymentioning

confidence: 99%

Axillary hyperhidrosis: A review of the extent of the problem and treatment modalities

2015

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Current treatments for axillary hyperhidrosis

Cited by 15 publications

References 47 publications

Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection

Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection

Topical local anaesthetic (tetracaine) reduces pain from botulinum toxin injections for axillary hyperhidrosis

Axillary hyperhidrosis: A review of the extent of the problem and treatment modalities

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