Current trends and advancements in crystallization and single-crystal structural analysis of small molecules

Xiao, Yuntian; Wu, Chuanhua; Zhou, Ling; Commins, Patrick; Li, Liang; Naumov, Panče; Yin, Qiuxiang

doi:10.1016/j.ccr.2024.216035

Coordination Chemistry Reviews

2024

DOI: 10.1016/j.ccr.2024.216035

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Current trends and advancements in crystallization and single-crystal structural analysis of small molecules

Yuntian Xiao,

Chuanhua Wu,

Ling Zhou

et al.

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2024

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Precise Nanochemistry of Spherical Aluminum Oxo Clusters for Accurate Surface Guest Recognition and Release

Fang,

Shen,

et al. 2024

Preprint

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Research on the adsorption of nanoparticles faces significant challenges due to their small size, which leads to ambiguous structures and renders traditional analytical methods inadequate for providing clear information. Nanoclusters, however, offer a promising solution to this issue, as their precise structural information and controllable features enable scientists to investigate surface adsorption phenomena and their behavior under various environmental conditions more effectively. In this study, we present a novel "co-encapsulation" synthetic strategy that successfully synthesizes the first spherical aluminum oxo cluster (SAlOC-1). This innovative approach draws inspiration from hydrophobic surfactant molecules found in spherical micelles and thus we select flexible, sterically hindered probenecid ligands as chelating ligands. The distinctive spherical structure of SAlOC-1 maximizes exposure of the surface binding sites, creating an optimal environment for guest inclusion. Notably, SAlOC-1 demonstrates a single crystal to single crystal transformation at room temperature, showcasing its remarkable capacity to accommodate up to 14 different drug-related guests across a broad volume range. These findings illustrate the unique advantages of SAlOC-1 in guest determination, including the ability to overcome limitations associated with liquid-phase host-guest chemistry in traditional discrete systems, ease of operation, and the coexistence of universality and selectivity. The implications of this work extend across numerous fields, including drug delivery, catalysis, and beyond.

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Precise Nanochemistry of Spherical Aluminum Oxo Clusters for Accurate Surface Guest Recognition and Release

Fang,

Shen,

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

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Current trends and advancements in crystallization and single-crystal structural analysis of small molecules

Cited by 1 publication

References 286 publications

Precise Nanochemistry of Spherical Aluminum Oxo Clusters for Accurate Surface Guest Recognition and Release

Precise Nanochemistry of Spherical Aluminum Oxo Clusters for Accurate Surface Guest Recognition and Release

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