Current trends and future challenges in neonatal parenteral nutrition

Adamkin, David H.; Radmacher, Paula G.

doi:10.3233/npm-14814008

Cited by 26 publications

(25 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In these cases, bilirubin levels in hemolysate must be measured. Parenteral alimentation with lipids is normally provided as nutrition to preterm infants or sickly newborns 19 . Although the bilirubin oxidase method is affected by the presence of serum hemoglobin and lipid emulsion 11 , we found in this study that hemolysate or serum containing emulsion did not affect unconjugated bilirubin measurement by the UnaG method.…”

Section: Discussionmentioning

confidence: 99%

Fluorescent protein-based detection of unconjugated bilirubin in newborn serum

Iwatani

Nakamura

Kurokawa

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Increased serum levels of unconjugated bilirubin are associated with the development of brain damage in newborns. In current clinical settings, there are no methods for directly determining serum levels of unconjugated bilirubin. UnaG, a fluorescent protein from Japanese eel muscle that specifically binds to unconjugated bilirubin was used in this study. Linear regression analysis was carried out to compare unconjugated bilirubin levels measured by UnaG and conventional bilirubin oxidase methods. Unconjugated bilirubin levels in the serum of newborns who were untreated or treated with phototherapy were compared. Effects of interfering factors in the serum (conjugated bilirubin, hemoglobin, and lipid) on unconjugated bilirubin concentration measured by the UnaG method were also evaluated. Unconjugated bilirubin levels measured by the UnaG method were highly correlated with those determined by the bilirubin oxidase assay. Unconjugated bilirubin levels determined by bilirubin oxidase and UnaG assays were similar in serum samples containing conjugated bilirubin. The performance of the UnaG assay was unaffected by phototherapy and the presence of serum hemoglobin and lipid emulsion. These results demonstrate the clinical applicability of the UnaG method for direct measurement of unconjugated bilirubin levels in newborn serum.

show abstract

Section: Discussionmentioning

confidence: 99%

Fluorescent protein-based detection of unconjugated bilirubin in newborn serum

Iwatani

Nakamura

Kurokawa

et al. 2016

Sci Rep

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated that newborns fed exclusively with breast milk showed lower levels of phosphate than those receiving special formulas or mineral supplementation (16). In addition, preterm infants fed with unfortified human milk present rickets in 40% of the cases, compared to the 16% of those fed with special formulas (17). It has also been demonstrated that phosphate supplementation improves the biochemical markers of MBD in a cohort of preterm infants with low gestational age and birth weight more than in a cohort of preterm newborns with higher gestational age and birth weight (18).…”

Section: Introductionmentioning

confidence: 99%

Metabolic Bone Disease of Prematurity: Diagnosis and Management

Faienza

D’Amato

Natale³

et al. 2019

Front. Pediatr.

114

138

View full text Add to dashboard Cite

Metabolic Bone Disease (MBD) of prematurity is a multifactorial disorder commonly observed in very low birth weight (VLBW, <1,500 g) newborns, with a greater incidence in those extremely low birth weight (ELBW, <1,000 g). MBD is characterized by biochemical and radiological findings related to bone demineralization. Several antenatal and postnatal risk factors have been associated to MBD of prematurity, although the main pathogenetic mechanism is represented by the reduced placental transfer of calcium and phosphate related to preterm birth. The diagnosis of MBD of prematurity requires the assessment of several biochemical markers, radiological, and ultrasonographic findings. However, the best approach is the prevention of the symptomatic disease, based on the screening of subjects exposed to the risks of developing MBD. Regarding the subjects who need to be screened, there is a substantial agreement on the potential risk factors for MBD. On the contrary, different recommendations exist on the diagnosis, management and treatment of this disorder of bone metabolism. This review was aimed at: (1) identifying the subjects at risk for MBD of prematurity; (2) indicating the biochemical findings to take in consideration for the prevention of MBD of prematurity; (3) suggesting practical recommendations on nutritional intake and supplementation in these subjects. We searched for papers which report the current recommendations for biochemical assessment of MBD of prematurity and for its prevention and treatment. The majority of the authors suggest that MBD of prematurity is a disease which tends to normalize overtime, thus it is not mandatory to mimic the rate of mineral fetal accretion through parenteral or enteral supplementation. The optimization of total parenteral nutrition (TPN) and the early achievement of a full enteral feeding are important goals for the prevention and management of MBD of prematurity.

show abstract

“…Hypernatremia with weight gain suggests salt and water load and needs fluid and sodium restriction [ 148 ]. The daily protein and lipid requirement in ELBW/VLBW neonates is around 4-4.5 gm/kg/day and 3 gm/kg/day respectively [ 149 – 151 ]. The venous access should be secured in these newborn and intravenous fluids should be started at earliest to prevent hypoglycemia.…”

Section: Introductionmentioning

confidence: 99%

Golden hour of neonatal life: Need of the hour

Sharma

2017

matern health, neonatol and perinatol

View full text Add to dashboard Cite

“Golden Hour” of neonatal life is defined as the first hour of post-natal life in both preterm and term neonates. This concept in neonatology has been adopted from adult trauma where the initial first hour of trauma management is considered as golden hour. The “Golden hour” concept includes practicing all the evidence based intervention for term and preterm neonates, in the initial sixty minutes of postnatal life for better long-term outcome. Although the current evidence supports the concept of golden hour in preterm and still there is no evidence seeking the benefit of golden hour approach in term neonates, but neonatologist around the globe feel the importance of golden hour concept equally in both preterm and term neonates. Initial first hour of neonatal life includes neonatal resuscitation, post-resuscitation care, transportation of sick newborn to neonatal intensive care unit, respiratory and cardiovascular support and initial course in nursery. The studies that evaluated the concept of golden hour in preterm neonates showed marked reduction in hypothermia, hypoglycemia, intraventricular hemorrhage (IVH), bronchopulmonary dysplasia (BPD), and retinopathy of prematurity (ROP). In this review article, we will discuss various components of neonatal care that are included in “Golden hour” of preterm and term neonatal care.

show abstract

Current trends and future challenges in neonatal parenteral nutrition

Cited by 26 publications

References 39 publications

Fluorescent protein-based detection of unconjugated bilirubin in newborn serum

Fluorescent protein-based detection of unconjugated bilirubin in newborn serum

Metabolic Bone Disease of Prematurity: Diagnosis and Management

Golden hour of neonatal life: Need of the hour

Contact Info

Product

Resources

About