Current Trends and Perspectives in the Immune Therapy for Substance Use Disorders

Vasiliu, O.

doi:10.3389/fpsyt.2022.882491

Cited by 15 publications

(16 citation statements)

References 25 publications

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“…In conclusion, the necessity of investigating the available treatments for B/SD is derived from multiple factors: the use of excessive buying as a way to cope with stress or isolation ( 27 ); negative functional consequences and risk of a chronic course ( 28 ); and the relatively high and increasing prevalence of problematic buying in the general population ( 1 , 16 ). The need to assess the efficacy of psychotherapeutic, pharmacological and combined therapies in BAs or SUDs is also motivated by the high societal and personal costs associated with healthcare in B/SD, high risk of psychiatric or somatic comorbidity, and lower quality of life ( 29 ).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic management of buying/shopping disorder: A systematic literature review and evidence-based recommendations

Vasiliu¹

2022

Front. Psychiatry

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The prevalence of buying/shopping disorder (B/SD) has been increasing in the last two decades, and this disorder has a substantial negative impact on general functioning and quality of life. Therefore, a systematic review of the studies dedicated to the efficacy and tolerability of therapeutic interventions, both psychological and pharmacological, might help clinicians to decide on the most evidence-based treatment for these patients. In order to further increase the clinical usefulness of the current review, GRADE-based recommendations were formulated, where enough evidence was found to support such an approach. A number of five electronic databases were searched for single case reports, case series, open-label and double-blind, placebo/active intervention-controlled trials, but other secondary reports (i.e., systematic reviews and meta-analyses) were also included in this analysis. Studies with unspecified designs or those that do not report either qualitatively or quantitively the evolution of B/SD core manifestations were excluded. All data included in the secondary analysis were evaluated using the Joanna Briggs Institute critical appraisal checklists. A total number of 24 manuscripts (i.e., 12 clinical trials, eight case reports, and four reviews) were included. Most of the reviewed studies were of moderate quality, representing a certain limitation of this review and preventing the formulation of high-validity recommendations. Psychotherapy, especially cognitive behavioral therapy (CBT) seems to be the main intervention supported by the current evidence, followed by the combination of antidepressants and CBT, and serotoninergic antidepressants as monotherapy. There is an obvious need to further develop good-quality trials with a more significant number of participants with B/SD and longer follow-up periods.

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Section: Introductionmentioning

confidence: 99%

Therapeutic management of buying/shopping disorder: A systematic literature review and evidence-based recommendations

Vasiliu¹

2022

Front. Psychiatry

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“…While significant progress has been made in understanding the neurobiology and behavioral aspects of addiction, the development of targeted medications has proven challenging. So far, there is no drug treatment approved by the FDA (Food and Drug Administration) or EMA (European Medicines Agency) for most substance use disorders, except for AUD (Alcohol Use Disorder), NUD (Nicotine Use Disorder), and OUD (Opioid Use Disorder) [26].…”

Section: Pharmacology and Treatment Insights On Sudmentioning

confidence: 99%

“…No FDA-or EMA-approved drug treatment for most substance use disorders [26] Lack of officially approved pharmaceutical treatments for most substance use disorders.…”

Section: Pharmacology and Treatmentmentioning

confidence: 99%

A Multi-Level Analysis of Biological, Social, and Psychological Determinants of Substance Use Disorder and Co-Occurring Mental Health Outcomes

Belfiore,

Galofaro,

Cotroneo

et al. 2024

Psychoactives

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We explored the intricate interplay of biological, social, and psychological factors contributing to substance use disorder (SUD) and co-occurring psychiatric symptoms. Drug misuse is a global concern, with increasing prevalence rates affecting mental well-being and safety. The spectrum of SUD includes polysubstance users, posing challenges for treatment and associated health outcomes. Various psychoactive substances like cannabis, hallucinogens, opioids, and stimulants impact addiction vulnerability, with marijuana being widely used globally. Gender differences in SUD prevalence have narrowed, with women escalating drug consumption rapidly once initiated. Age disparities in substance use highlight regional variations among adolescents. Comorbidities with psychiatric symptoms are common, with mood and anxiety disorders frequently observed. This study aimed to analyze factors influencing SUD development and maintenance to inform prevention strategies and treatment recommendations. By conducting a systematic search of databases, sixty articles were reviewed, revealing diverse methodologies and geographic locations. Biological factors, including neurotransmitter systems like endocannabinoid and dopaminergic systems, play a significant role in addiction. Genetic and neurobiological factors contribute to cannabis addiction susceptibility. Social factors such as childhood experiences and parenting styles influence substance use behaviors. Psychological factors like personality traits and mental health conditions interact with SUD development. Understanding these multifaceted interactions is crucial for designing effective interventions to address the complexities of SUD and co-occurring psychiatric symptoms.

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“…The excessive use of alcohol may affect GM in human and animal models, leading to a dysbiosis that can represent an essential link in the pathogenesis of alcohol use disorders (AUD). Most of the data regarding this subject are derived from animal studies, which showed a connection between chronic alcohol use and increased oxidative stress, higher intestinal permeability to different bacteriaproduced toxic factors, and the onset of alcoholic hepatitis (2,74). Increased dysbiosis may determine systemic inflammation and endotoxemia, as well as specific organ pathologies, supporting, at a theoretical level, the usefulness of a probiotic or synbiotic modulation of the GM as prophylactic measures or therapeutic interventions in AUD (2).…”

Section: Substance Use Disordersmentioning

confidence: 99%

The current state of research for psychobiotics use in the management of psychiatric disorders–A systematic literature review

Vasiliu¹

2023

Front. Psychiatry

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The need to find new therapeutic interventions in patients diagnosed with psychiatric disorders is supported by the data suggesting high rates of relapse, chronic evolution, therapeutic resistance, or lack of adherence and disability. The use of pre-, pro-, or synbiotics as add-ons in the therapeutic management of psychiatric disorders has been explored as a new way to augment the efficacy of psychotropics and to improve the chances for these patients to reach response or remission. This systematic literature review focused on the efficacy and tolerability of psychobiotics in the main categories of psychiatric disorders and it has been conducted through the most important electronic databases and clinical trial registers, using the PRISMA 2020 guidelines. The quality of primary and secondary reports was assessed using the criteria identified by the Academy of Nutrition and Diabetics. Forty-three sources, mostly of moderate and high quality, were reviewed in detail, and data regarding the efficacy and tolerability of psychobiotics was assessed. Studies exploring the effects of psychobiotics in mood disorders, anxiety disorders, schizophrenia spectrum disorders, substance use disorders, eating disorders, attention deficit hyperactivity disorder (ADHD), neurocognitive disorders, and autism spectrum disorders (ASD) were included. The overall tolerability of the interventions assessed was good, but the evidence to support their efficacy in specific psychiatric disorders was mixed. There have been identified data in favor of probiotics for patients with mood disorders, ADHD, and ASD, and also for the association of probiotics and selenium or synbiotics in patients with neurocognitive disorders. In several domains, the research is still in an early phase of development, e.g., in substance use disorders (only three preclinical studies being found) or eating disorders (one review was identified). Although no well-defined clinical recommendation could yet be formulated for a specific product in patients with psychiatric disorders, there is encouraging evidence to support further research, especially if focused on the identification of specific sub-populations that may benefit from this intervention. Several limitations regarding the research in this field should be addressed, i.e., the majority of the finalized trials are of short duration, there is an inherent heterogeneity of the psychiatric disorders, and the diversity of the explored Philae prevents the generalizability of the results from clinical studies.

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Current Trends and Perspectives in the Immune Therapy for Substance Use Disorders

Cited by 15 publications

References 25 publications

Therapeutic management of buying/shopping disorder: A systematic literature review and evidence-based recommendations

Therapeutic management of buying/shopping disorder: A systematic literature review and evidence-based recommendations

A Multi-Level Analysis of Biological, Social, and Psychological Determinants of Substance Use Disorder and Co-Occurring Mental Health Outcomes

The current state of research for psychobiotics use in the management of psychiatric disorders–A systematic literature review

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