2004
DOI: 10.1159/000075988
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Current Trends in Heart Transplantation

Abstract: With the introduction of cyclosporin A in the early 1980s, heart transplantation was transformed from an experimental procedure into a successful therapeutic option for patients with end-stage heart disease. Since then, constant progress has extended the benefits of the procedure to an increasing number of patients. Despite all this progress, heart transplantation is not an option that can be offered to the vast majority of the world population, in particular to the over 5 billion inhabitants of underdeveloped… Show more

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Cited by 31 publications
(22 citation statements)
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“…The increasing use of older donor hearts will possibly be necessary as the numbers of available grafts continue to decline. It is believed that about 15 000 patients would potentially benefit from a heart transplant, if the acceptance criteria included 'marginal' donors up to 55 years of age, and about 40 000-70 000 patients would benefit, if the acceptance age was extended to 65 years [159]. However, regardless of the changes made in the acceptance of marginal donors, any such mechanism will not be considered successful unless recipient graft survival rates in center-specific outcome analyses remain acceptable.…”
Section: Resultsmentioning
confidence: 99%
“…The increasing use of older donor hearts will possibly be necessary as the numbers of available grafts continue to decline. It is believed that about 15 000 patients would potentially benefit from a heart transplant, if the acceptance criteria included 'marginal' donors up to 55 years of age, and about 40 000-70 000 patients would benefit, if the acceptance age was extended to 65 years [159]. However, regardless of the changes made in the acceptance of marginal donors, any such mechanism will not be considered successful unless recipient graft survival rates in center-specific outcome analyses remain acceptable.…”
Section: Resultsmentioning
confidence: 99%
“…Conventional therapeutic options for the treatment of myocardial infarction (MI) are limited to preventing the progression of ventricular remodeling and congestive heart failure (22). Currently, the only successful treatment for end-stage heart failure is heart transplantation (9,18). Even if a suitable donor is found, cardiac allograft vasculopathy characterized by a diffuse process of concentric narrowing of the whole arterial allograft microvasculature may result in high morbidity and mortality among long-term heart transplant recipients (36).…”
mentioning
confidence: 99%
“…At present, one-year survival approaches 85%, fiveyear survival is approximately 75% and 50% of adult recipients will be alive for 10 years [78]. Survival is best for patients: (1) with congenital and dilated cardiomyopathies;…”
Section: Cardiac Transplantationmentioning
confidence: 99%