Current Trends in Pharmacological Treatment of Type 2 Diabetes Mellitus in Tertiary Care Centre in Bundelkhand Region

Abstract

Introduction: Type 2 diabetes mellitus (DM) is a chronic metabolic condition with an increasing global prevalence. Because of this tendency, it is rapidly becoming an epidemic in some nations, with the number of affected anticipated to quadruple in the next decade as the population ages. The present study aimed to determine the prescribing pattern and adverse drug reaction of different groups of antidiabetic drug in type 2 Diabetes mellitus. Methodology: The present study was an analytical cross-sectional study conducted on total 430 type II diabetes mellitus patients attending OPD in diabetes clinic at M.L.B Medical College, Jhansi during the study period. Various scoring system including WHO causality assessment scale, CDSCO ADR, WHO-UMC Scale, Naranjo algorithm scale were used for assessment. Results: Majority of patients were male [n=248(57.67%) followed by female [n=182(42.33%], respectively. Signicant patients were of middle class [n=201(46.74%) followed by low class [n=139(32.32%] and High class [n=90(20.93%) (P<0.0001*). ADRs reported hypoglycemia was the commonest followed by dyspepsia and epigastric pain and heart burn common. Majority of patients had HbA1c between 7.0-8.0 which is in fair control 37.67% followed by 8.0-10.0 which is unsatisfactory 35.81% and above 10 which is in poor control 18.14% respectively. Signicant Correlation between Medicine with ADR (p=0.0429), Total Cholesterol (p=0.0396*) and Triglycerides (p= 0.0167*). Conclusion: According to causality assessments, majority of patients had possible causalities. Therefore, we may say that present study results provide insight to the healthcare providers on the importance of monitoring and reporting ADR associated with the drugs.