Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach

Abat, Ferrán; Alfredson, Håkan; Cucchiarini, Magali; Madry, Henning; Marmotti, Antonio; Mouton, Caroline; Oliveira, Joaquím M.; Pereira, Hélder; Peretti, Giuseppe M.; Romero-Rodríguez, Dani; Spang, Christoph; Stephen, Joanna M.; Bergen, Christian J A van; Girolamo, Laura de

doi:10.1186/s40634-017-0092-6

Cited by 83 publications

(56 citation statements)

References 109 publications

(149 reference statements)

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“…Generally, Achilles tendon ruptures occur with different frequencies at various anatomical locations: 75% at the mid-substance, 10%-20% at the distal enthesis, and 5%-15% at the myotendinous junction [19]. According to current trends, Patellar tendinopathy is another common load-induced injury with a prevalence of 45% in volleyball players and 32% in basketball players [20]. Lateral epicondylitis, which is also known as tennis elbow, is a frequent injury that not only occurs in athletes but also in the general population with an incidence of 4-7 people per 1000 per year [21].…”

Section: Morbidity and Clinical Relevance Of Tendinopathiesmentioning

confidence: 99%

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

Steinmann

Pfeifer

Brochhausen

et al. 2020

IJMS

101

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The biggest compartment of the musculoskeletal system is the tendons and ligaments. In particular, tendons are dense tissues connecting muscle to bone that are critical for the integrity, function and locomotion of this system. Due to the increasing age of our society and the overall rise in engagement in extreme and overuse sports, there is a growing prevalence of tendinopathies. Despite the recent advances in tendon research and due to difficult early diagnosis, a multitude of risk factors and vague understanding of the underlying biological mechanisms involved in the progression of tendon injuries, the toolbox of treatment strategies remains limited and non-satisfactory. This review is designed to summarize the current knowledge of triggers, trails and end state of tendinopathies.

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Section: Morbidity and Clinical Relevance Of Tendinopathiesmentioning

confidence: 99%

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

Steinmann

Pfeifer

Brochhausen

et al. 2020

IJMS

101

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“…Its use has been approved by the Food and Drug Administration for some related indications 26. Exercise-based therapies, including eccentric training protocols, have also been proposed and remain subject of development 27. Treatment effectiveness may be measured using Patient Reported Outcome Measures (table 2).…”

Section: Current State Of the Artmentioning

confidence: 99%

Ankle tendoscopy: state of the art

Pereira¹,

Vuurberg

Stone

et al. 2017

Journal of ISAKOS

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“…Treatment of tendinopathy still represents an unsolved challenge. Mainly, the use of strict rehabilitation exercise regimens is sufficiently evidence based [17,18]. Anti-inflammatory drugs are frequently used, but they do not only counteract the active inflammation but also its resolution [19].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

Burk¹

2019

Tendons

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Multipotent mesenchymal stromal cells (MSCs) are a promising therapeutic tool to treat tendon disease. Aiming to establish successful treatment approaches and to fully exploit the regenerative potential of the MSC, it is crucial to understand their mechanisms of action. However, these can be multifaceted and strongly context-sensitive and are still not well-understood in the context of tendon disease. This review aims to shed light on the different possible mechanisms, including engraftment, tenogenic differentiation, extracellular matrix synthesis and remodeling, immunomodulation, pro-angiogenetic effects, trophic support, and protection of resident tendon cells. Evidence from experimental and clinical (veterinary) case studies was compiled and interpreted in conjunction with the respective in vitro and animal models used.

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Current trends in tendinopathy: consensus of the ESSKA basic science committee. Part I: biology, biomechanics, anatomy and an exercise-based approach

Cited by 83 publications

References 109 publications

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

Spectrum of Tendon Pathologies: Triggers, Trails and End-State

Ankle tendoscopy: state of the art

Mechanisms of Action of Multipotent Mesenchymal Stromal Cells in Tendon Disease

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