“…66 Results showed that intranasal ketamine was not superior to IV metoclopramide; however, the study suggests that intranasal ketamine may have pain-reliving effects comparable to IV migraine abortive therapies. A review of treatment trends in the ED found an increase in ketamine use in pediatric patients presenting with lacerations and skeletal fractures; 67 however, there is a lack of studies evaluating the use of ketamine specifically for acute migraine treatment in the pediatric population. One longitudinal cohort study of 63 pediatric patients treated at a tertiary care center for various chronic pain conditions, including migraine (13%), reported that "ketamine-associated reductions in pain scores were the largest in postural orthostatic tachycardia syndrome and trauma patients and the smallest in patients with chronic headache."…”