Current trends in the treatment of polycystic ovary syndrome with desire for children

Checa, Miguel Ángel

doi:10.2147/tcrm.s3779

Cited by 7 publications

(2 citation statements)

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“…The researchers discovered that a small weight loss achieved through lifestyle adjustments was sufficient to alter PCOS patients’ menstrual cycles, and that metformin had additive effects on insulin resistance and hyperandrogenism. In obese PCOS women, weight loss of just 5% of their starting body weight can result in conception ( 131 ), whereas weight loss of 5–10% can lower hyperandrogenism and insulin levels ( 132 ).…”

Section: Current Clinical Treatment Of Pcosmentioning

confidence: 99%

Resistance to the Insulin and Elevated Level of Androgen: A Major Cause of Polycystic Ovary Syndrome

Ding

Zhang

et al. 2021

Front. Endocrinol.

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PCOS has a wide range of negative impacts on women’s health and is one of the most frequent reproductive systemic endocrine disorders. PCOS has complex characteristics and symptom heterogeneity due to the several pathways that are involved in the infection and the absence of a comm14on cause. A recent study has shown that the main etiology and endocrine aspects of PCOS are the increased level of androgen, which is also known as “hyperandrogenemia (HA)” and secondly the “insulin resistance (IR)”. The major underlying cause of the polycystic ovary is these two IR and HA, by initiating the disease and its severity or duration. As a consequence, study on Pathogenesis is crucial to understand the effect of “HA” and “IR” on the pathophysiology of numerous symptoms linked to PCOS. A deep understanding of the pattern of the growth in PCOS for HA and IR can help ameliorate the condition, along with adjustments in nutrition and life, as well as the discovery of new medicinal products. However, further research is required to clarify the mutual role of IR and HA on PCOS development.

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Section: Current Clinical Treatment Of Pcosmentioning

confidence: 99%

Resistance to the Insulin and Elevated Level of Androgen: A Major Cause of Polycystic Ovary Syndrome

Ding

Zhang

et al. 2021

Front. Endocrinol.

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“…The second possible line of therapy after resistance to CC has been demonstrated in women with PCOS is exogenous gonadotropins. 37 The mechanism of action of gonadotropins is to induce ovulation, maintain and provoke optimum follicle growth via the controlled administration of FSH, and achieve a follicle capable of being fertilized. Unlike CC, gonadotropin does not exert a peripheral antiestrogenic effect.…”

Section: Management Of Pcosmentioning

confidence: 99%

Treatment options for polycystic ovary syndrome

Badawy¹,

Elnashar²

2011

IJWH

522

236

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women. The clinical manifestation of PCOS varies from a mild menstrual disorder to severe disturbance of reproductive and metabolic functions. Management of women with PCOS depends on the symptoms. These could be ovulatory dysfunction-related infertility, menstrual disorders, or androgen-related symptoms. Weight loss improves the endocrine profile and increases the likelihood of ovulation and pregnancy. Normalization of menstrual cycles and ovulation could occur with modest weight loss as little as 5% of the initial weight. The treatment of obesity includes modifications in lifestyle (diet and exercise) and medical and surgical treatment. In PCOS, anovulation relates to low follicle-stimulating hormone concentrations and the arrest of antral follicle growth in the final stages of maturation. This can be treated with medications such as clomiphene citrate, tamoxifen, aromatase inhibitors, metformin, glucocorticoids, or gonadotropins or surgically by laparoscopic ovarian drilling. In vitro fertilization will remain the last option to achieve pregnancy when others fail. Chronic anovulation over a long period of time is also associated with an increased risk of endometrial hyperplasia and carcinoma, which should be seriously investigated and treated. There are androgenic symptoms that will vary from patient to patient, such as hirsutism, acne, and/or alopecia. These are troublesome presentations to the patients and require adequate treatment. Alternative medicine has been emerging as one of the commonly practiced medicines for different health problems, including PCOS. This review underlines the contribution to the treatment of different symptoms.

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