Current trends in theranostic nanomedicines

Shete, Meghanath B.; Patil, Tulshidas S.; Deshpande, Ashwini; Saraogi, Gaurav Kant; Vasdev, Nupur; Deshpande, M. K.; Rajpoot, Kuldeep; Tekade, Rakesh K.

doi:10.1016/j.jddst.2022.103280

Cited by 32 publications

(12 citation statements)

References 127 publications

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“…Theranostics is a nanomedicine that comprises of both diagnosis and therapies of illnesses achieved by using a biomaterial based nanoplatform. This nanomedicine technology uses nanostructures within the 1 to 100 nm range that are functionalised with organic or inorganic materials and often with an engineered compound such as phthalocyanine that could disrupt the functionality of the cells of the infectious disease [75]. The functional groups on the surface of the nanoparticles usually directs them to the desired location of the infectious disease that could be detected using ultrasound, MRI, or CT scans (diagnosis).…”

Section: Theranosticsmentioning

confidence: 99%

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Application of Plasmonic Nanostructures in Molecular Diagnostics and Biosensor Technology: Challenges and Current Developments

Nyembe¹,

Mkhohlakali²,

May³

et al. 2023

Plasmonic Nanostructures - Basic Concepts, Optimization and Applications

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The recent global pandemic caused by Covid-19 enforced the urgent need for accessible, reliable, and accurate point-of-care rapid diagnostics based on plasmonic nanostructures. This is because fast and reliable testing was the key driver in curbing the spread of Covid-19. The traditional methods of diagnostics and biosensors often require expensive infrastructure and highly qualified and trained personnel, which limits their accessibility. These limitations perpetuated the impact of Covid-19 in most countries because of the lack of easily accessible point-of-care rapid diagnostic kits. This review revealed that portable and reliable point-of-care diagnostic kits are very crucial in reaching large populations, especially in underdeveloped and developing countries. This gives perspective to novel point-of-care applications. Furthermore, water quality is a very crucial part of food safety, especially in developing countries faced with water contamination. In this chapter, we explored the various challenges and recent developments in the use of plasmonic nanostructures for application in molecular diagnostics and biosensing for the detection of infectious diseases and common environmental pathogens.

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Section: Theranosticsmentioning

confidence: 99%

“…The various morphology of plasmonic nanoparticles is shown in Table 1. Various therapies and diagnostic approaches used for the theranostic concept [75].…”

Section: Machine Learningmentioning

confidence: 99%

Application of Plasmonic Nanostructures in Molecular Diagnostics and Biosensor Technology: Challenges and Current Developments

Nyembe¹,

Mkhohlakali²,

May³

et al. 2023

Plasmonic Nanostructures - Basic Concepts, Optimization and Applications

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“…20,21 In recent years, substantial efforts have been dedicated to fine-tuning the size, shape, and structure of plasmonic nanoparticles to enhance their photothermal performance and SERS activity. 22 Various gold nanostructures, such as nanorattles, 16,23 nanorods, nanoshells, nanocages, and nanostars, have been reported, demonstrating their potential in photothermal therapy and SERS-based bioimaging. 24 However, for broader applications, there is a crucial need for improved SERS active probes and tunable NIR-responsive photothermal nanoagents.…”

Section: ■ Introductionmentioning

confidence: 99%

NIR-Active Gold Dogbone Nanorattles Impregnated in Cationic Dextrin Nanoparticles for Cancer Nanotheranostics

Sarkar,

Singh,

Bhardwaj

et al. 2024

ACS Biomater. Sci. Eng.

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Theranostic systems, which integrate therapy and diagnosis into a single platform, have gained significant attention as a promising approach for noninvasive cancer treatment. The field of image-guided therapy has revolutionized real-time tumor detection, and within this domain, plasmonic nanostructures have garnered significant attention. These structures possess unique localized surface plasmon resonance (LSPR), allowing for enhanced absorption in the near-infrared (NIR) range. By leveraging the heat generated from plasmonic nanoparticles upon NIR irradiation, target cancer cells can be effectively eradicated. This study introduces a plasmonic gold dogbone-nanorattle (AuDB NRT) structure that exhibits broad absorption in the NIR region and demonstrates a photothermal conversion efficiency of 35.29%. When exposed to an NIR laser, the AuDB NRTs generate heat, achieving a maximum temperature rise of 38 °C at a concentration of 200 μg/mL and a laser power density of 3 W/cm 2 . Additionally, the AuDB NRTs possess intrinsic electromagnetic hotspots that amplify the signal of a Raman reporter molecule, making them an excellent probe for surface-enhanced Raman scattering-based bioimaging of cancer cells. To improve the biocompatibility of the nanorattles, the AuDB NRTs were conjugated with mPEG-thiol and successfully encapsulated into cationic dextrin nanoparticles (CD NPs). Biocompatibility tests were performed on HEK 293 A and MCF-7 cell lines, revealing high cell viability when exposed to AuDB NRT-CD NPs. Remarkably, even at a low laser power density of 1 W/cm 2 , the application of the NIR laser resulted in a remarkable 80% cell death in cells treated with a nanocomposite concentration of 100 μg/mL. Further investigation elucidated that the cell death induced by photothermal heat followed an apoptotic mechanism. Overall, our findings highlight the significant potential of the prepared nanocomposite for cancer theranostics, combining effective photothermal therapy along with the ability to image cancer cells.

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“…In order to address a synergistic strategy to combat metastatic tumors, nanomedicines are currently being used to entrap traditional therapeutics and diagnostic equipment [ 6 , 7 , 8 ]. According to the current circumstances, developing new delivery systems that are quick and simple to prepare, affordable, have high drug loading efficiency, are stable under biological conditions, encourage drug retention in tissues, and are tailored for the delivery of already-approved FDA-approved drugs is the quickest and most practical way to improve the cancer treatment regimen [ 9 ]. In this regard, polymeric micellar systems have demonstrated significant promise for the administration of lipophilic medicines, small molecules, and proteins for the treatment of cancer, as well as potential advantages to carrier imaging moieties aiming at cancer theranostics [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

Neguț

Biţă

2023

Pharmaceutics

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Concurrent developments in anticancer nanotechnological treatments have been observed as the burden of cancer increases every year. The 21st century has seen a transformation in the study of medicine thanks to the advancement in the field of material science and nanomedicine. Improved drug delivery systems with proven efficacy and fewer side effects have been made possible. Nanoformulations with varied functions are being created using lipids, polymers, and inorganic and peptide-based nanomedicines. Therefore, thorough knowledge of these intelligent nanomedicines is crucial for developing very promising drug delivery systems. Polymeric micelles are often simple to make and have high solubilization characteristics; as a result, they seem to be a promising alternative to other nanosystems. Even though recent studies have provided an overview of polymeric micelles, here we included a discussion on the “intelligent” drug delivery from these systems. We also summarized the state-of-the-art and the most recent developments of polymeric micellar systems with respect to cancer treatments. Additionally, we gave significant attention to the clinical translation potential of polymeric micellar systems in the treatment of various cancers.

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Current trends in theranostic nanomedicines

Cited by 32 publications

References 127 publications

Application of Plasmonic Nanostructures in Molecular Diagnostics and Biosensor Technology: Challenges and Current Developments

Application of Plasmonic Nanostructures in Molecular Diagnostics and Biosensor Technology: Challenges and Current Developments

NIR-Active Gold Dogbone Nanorattles Impregnated in Cationic Dextrin Nanoparticles for Cancer Nanotheranostics

Polymeric Micellar Systems—A Special Emphasis on “Smart” Drug Delivery

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