Current understanding of comparative pathology and prospective research approaches for canine hemangiosarcoma

Suzuki, Tamami; Henshaw, Michael James; Yanagi, Teruki; Aoshima, Keisuke

doi:10.1016/j.rvsc.2023.105120

Research in Veterinary Science

2024

DOI: 10.1016/j.rvsc.2023.105120

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Current understanding of comparative pathology and prospective research approaches for canine hemangiosarcoma

Tamami Suzuki,

Michael James Henshaw,

Teruki Yanagi

et al.

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2024

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Cited by 1 publication

References 73 publications

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Genomic landscape and preclinical models of angiosarcoma

Benton,

Liu,

Gartenhaus

et al. 2024

Molecular Oncology

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Angiosarcoma is a cancer that develops in blood or lymphatic vessels that presents a significant clinical challenge due to its rarity and aggressive features. Clinical outcomes have not improved in decades, highlighting a need for innovative therapeutic strategies to treat the disease. Genetically, angiosarcomas exhibit high heterogeneity and complexity with many recurrent mutations. However, recent studies have identified some common features within anatomic and molecular subgroups. To identify potential therapeutic vulnerabilities, it is essential to understand and integrate the mutational landscape of angiosarcoma with the models that exist to study the disease. In this review, we will summarize the insights gained from reported genomic alterations in molecular and anatomic subtypes of angiosarcoma, discuss several potential actionable targets, and highlight the preclinical disease models available in the field.

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Genomic landscape and preclinical models of angiosarcoma

Benton,

Liu,

Gartenhaus

et al. 2024

Molecular Oncology

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show abstract

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Current understanding of comparative pathology and prospective research approaches for canine hemangiosarcoma

Cited by 1 publication

References 73 publications

Genomic landscape and preclinical models of angiosarcoma

Genomic landscape and preclinical models of angiosarcoma

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