Current Understanding of COVID-19 Clinical Course and Investigational Treatments

Aguilar, Richard; Hardigan, Patrick C.; Mayi, Bindu; Sider, Darby; Piotrkowski, Jared; Mehta, J.P.; Dev, Jenankan; Seijo, Yelenis; Camargo, Antonio Lewis; Andux, Luis; Hagen, Kathleen; Hernandez, Marlow

doi:10.3389/fmed.2020.555301

Cited by 28 publications

(24 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 We excluded 19 CPGs (eFigure in Supplement 1 ). 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 Of the 32 included CPGs, 3 (9.4%) 15 , 38 , 40 reported on pharmacologic treatments for critically ill patients specifically, and the remainder reported on treatments for hospitalized patients with COVID-19. Fifteen CPGs (46.9%) were international 15 , 16 , …”

Section: Resultsmentioning

confidence: 99%

Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

et al. 2021

View full text Add to dashboard Cite

Key Points Question Do clinical practice guidelines (CPGs) that report on pharmacologic treatments of hospitalized patients with COVID-19 meet the National Academy of Medicine standards for trustworthiness? Findings In this systematic review of 32 CPGs of predominantly low quality, few reported funding sources or conflicts of interest, included a methodologist, described a search strategy or study selection process, or synthesized evidence. Although 14 CPGs (43.8%) made recommendations or suggestions for or against treatments, they infrequently rated the confidence in the quality of the evidence (6 [18.8%]), described potential benefits and harms (6 [18.8%]), or graded the strength of recommendations (5 [15.6%]). Meaning The findings of this study suggest that few COVID-19 CPGs meet National Academy of Medicine standards for trustworthy guidelines.

show abstract

Section: Resultsmentioning

confidence: 99%

Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Thirdly, patients who died in ICU were excluded from this study. With emerging evidenced-based management guidelines leading to increased survival rates of critically ill COVID-19 patients, it is possible that functional impairments may become more prevalent in this population ( 36 ). Fourthly, we only reported acute functional outcomes after ICU stay and hospital discharge.…”

Section: Discussionmentioning

confidence: 99%

Acute Functional Outcomes in Critically Ill COVID-19 Patients

et al. 2021

View full text Add to dashboard Cite

Background: COVID-19 (Coronavirus Disease 2019) is a global cause of morbidity and mortality currently. We aim to describe the acute functional outcomes of critically ill coronavirus disease 2019 (COVID-19) patients after transferring out of the intensive care unit (ICU).Methods: 51 consecutive critically ill COVID-19 patients at a national designated center for COVID-19 were included in this exploratory, retrospective observational cohort study from January 1 to May 31, 2020. Demographic and clinical data were collected and analyzed. Functional outcomes were measured primarily with the Functional Ambulation Category (FAC), and divided into 2 categories: dependent ambulators (FAC 0–3) and independent ambulators (FAC 4–5). Multivariate analysis was performed to determine associations.Results: Many patients were dependent ambulators (47.1%) upon transferring out of ICU, although 92.2% regained independent ambulation at discharge. On multivariate analysis, we found that a Charlson Comorbidity Index of 1 or more (odds ratio 14.02, 95% CI 1.15–171.28, P = 0.039) and a longer length of ICU stay (odds ratio 1.50, 95% CI 1.04–2.16, P = 0.029) were associated with dependent ambulation upon discharge from ICU.Conclusions: Critically ill COVID-19 survivors have a high level of impairment following discharge from ICU. Such patients should be screened for impairment and managed appropriately by rehabilitation professionals, so as to achieve good functional outcomes on discharge.

show abstract

“…3 ). In particular, for three areas (Val d’Aosta, Veneto and Emilia Romagna) there is an early minimum at 10–12 days, not reliable as defined by only one isolated point (Veneto) or too much early ( Aguilar et al, 2020 ; Argenziano et al, 2020 ); in Val d’Aosta, Veneto and Emilia Romagna the shape of the standard deviation points is rather flat, even if a minimum value can be identified.…”

Section: Resultsmentioning

confidence: 88%

Effects of environmental parameters and their interactions on the spreading of SARS-CoV-2 in North Italy under different social restrictions. A new approach based on multivariate analysis

Tateo

Fiorino

Peruzzo

et al. 2022

Environmental Research

View full text Add to dashboard Cite

In 2020 North Italy suffered the SARS-CoV-2-related pandemic with a high number of deaths and hospitalization. The effect of atmospheric parameters on the amount of hospital admissions (temperature, solar radiation, particulate matter, relative humidity and wind speed) is studied through about 8 months (May–December). Two periods are considered depending on different conditions: a) low incidence of COVID-19 and very few regulations concerning personal mobility and protection (“free/summer period”); b) increasing incidence of disease, social restrictions and use of personal protections (“confined/autumn period”). The “hospitalized people in medical area wards/100000 residents” was used as a reliable measure of COVID-19 spreading and load on the sanitary system. We developed a chemometric approach (multiple linear regression analysis) using the daily incidence of hospitalizations as a function of the single independent variables and of their products (interactions). Eight administrative domains were considered (altogether 26 million inhabitants) to account for relatively homogeneous territorial and social conditions. The obtained models very significantly match the daily variation of hospitalizations, during the two periods. Under the confined/autumn period, the effect of non-pharmacologic measures (social distances, personal protection, etc.) possibly attenuates the virus diffusion despite environmental factors. On the contrary, in the free/summer conditions the effects of atmospheric parameters are very significant through all the areas. Particulate matter matches the growth of hospitalizations in areas with low chronic particulate pollution. Fewer hospitalizations strongly correspond to higher temperature and solar radiation. Relative humidity plays the same role, but with a lesser extent. The interaction between solar radiation and high temperature is also highly significant and represents surprising evidence. The solar radiation alone and combined with high temperature exert an anti-SARS-CoV-2 effect, via both the direct inactivation of virions and the stimulation of vitamin D synthesis, improving immune system function.

show abstract

Current Understanding of COVID-19 Clinical Course and Investigational Treatments

Cited by 28 publications

References 54 publications

Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

Adherence of Clinical Practice Guidelines for Pharmacologic Treatments of Hospitalized Patients With COVID-19 to Trustworthy Standards

Acute Functional Outcomes in Critically Ill COVID-19 Patients

Effects of environmental parameters and their interactions on the spreading of SARS-CoV-2 in North Italy under different social restrictions. A new approach based on multivariate analysis

Contact Info

Product

Resources

About