Current Understanding of the Neural Stem Cell Niches

Llorente, Vicente; Velarde, P.; Desco, Manuel; Gómez-Gaviro, Marı́a Victoria

doi:10.3390/cells11193002

Cited by 30 publications

(18 citation statements)

References 270 publications

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“…In adult rodents, NSCs have been widely documented in the SVZ and the SGZ [ 21 , 22 ], but the hypothalamus, the neocortex and the inferior colliculus have recently been identified as new potential neurogenic zones [ 23 , 24 , 25 , 26 ]. In these neurogenic regions, quiescent and activated NSCs are present, generating new neurons throughout life [ 25 , 26 , 27 ].…”

Section: Discussionmentioning

confidence: 99%

“…Based on all this evidence, we may wonder whether the vestibular nuclei can be considered as a NSC niche, as is the case for the SVZ and the SGZ. By synthesizing data from several studies (for review, see [ 22 , 29 ]), we are able to propose a list of criteria that would assign a NSC niche status to a particular cerebral region. Obviously, not all niches integrate all these distinct elements, and it is clear that a neurogenic niche represents a complex and dynamic entity in which the integration of multiple signals allows precise control of the NSCs proliferation and survival.…”

Section: Discussionmentioning

confidence: 99%

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Vestibular Nuclei: A New Neural Stem Cell Niche?

Rastoldo

Watabe

Lapotre

et al. 2022

Cells

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We previously reported adult reactive neurogliogenesis in the deafferented vestibular nuclei following unilateral vestibular neurectomy (UVN) in the feline and the rodent model. Recently, we demonstrated that UVN induced a significant increase in a population of cells colocalizing the transcription factor sex determining region Y-box 2 (SOX2) and the glial fibrillary acidic protein (GFAP) three days after the lesion in the deafferented medial vestibular nucleus. These two markers expressed on the same cell population could indicate the presence of lesion-reactive multipotent neural stem cells in the vestibular nuclei. The aim of our study was to provide insight into the potential neurogenic niche status of the vestibular nuclei in physiological conditions by using specific markers of stem cells (Nestin, SOX2, GFAP), cell proliferation (BrdU) and neuronal differentiation (NeuN). The present study confirmed the presence of quiescent and activated adult neural stem cells generating some new neurons in the vestibular nuclei of control rats. These unique features provide evidence that the vestibular nuclei represent a novel NSC site for the generation of neurons and/or glia in the adult rodent under physiological conditions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vestibular Nuclei: A New Neural Stem Cell Niche?

Rastoldo

Watabe

Lapotre

et al. 2022

Cells

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“…As a consequence of this, gapping is also a technical flaw that, in theory, can be remedied by a repair that is more long-lasting & uses less plastic. It is well established that early mobilization improves the overall result of flexor tendon repairs [4].…”

Section: Introductionmentioning

confidence: 99%

Intratendinious Versus Extracorporeal Knot Four Strand Core Suture Repair of Flexor Tendon Injuries of the Hand Zone II

Halahal,

Abdelshaheed,

Elnahas

et al. 2024

The Egyptian Journal of Plastic and Reconstructive Surgery

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Background: Over the past few years, there has been a shift in how flexor tendons are repaired. Because of adhesions or ruptures that occurred when early active motion was attempted, flexor tendon repairs in the digit have a long history of producing disappointing outcomes.Objectives: To make an evaluation to the outcomes of flexor tendon repair using ordinary 4 strands suture with intratendinous knot technique and comparing it with four strands suture with extracorporeal knot. And comparing it with our innovation technique; The four-strand suture with extracorporeal knot. Subjects and Methods: This interventional prospective trial was performed on persons admitted to our emergency hospital and Burn and Plastic Surgery Center, Mansoura University with flexor tendon injuries zone II from February 2020 to February 2023. Patients were classified into two groups; group A treated with the 4-strand suture with extra corporeal knot, and group B treated with the 4-strand suture with intra tendinous knot.Results: Statistical analysis revealed a statistically significant distinction among the groups according to outcome, total active flexion (TAF) and total active range of motion (TARM) for group A, and operation time for group B. No statistically significant variations were observed amongst the groups as regard socio-demographic characteristics, injury location & dominant hand distribution among the study populations, anesthesia WALAIAT or General, follow up period, patient or parent's satisfaction, age and outcome of treatment. Conclusion:We noticed that the four strands suture with extracorporeal knot technique for flexor tendons repair zone II was easy to accomplish, had a lower volume and no bulk at the site of repair, with no suture knot inside tendon at site of repair, besides a more regular suture, that offer less interfering with tendon gliding, less adhesion formation, adequate strong repair for an early active post-operative mobilization protocol, good results, good total active range of motion and good patients satisfaction.

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“…Neural stem cells (NSCs) reside in neurogenic niches, such as the subgranular zone and subventricular zone of the adult brain, and have the ability to self-renew and the potential to differentiate into other cell lines, including neurons, oligodendrocytes, and astrocytes (Llorente et al, 2022). Hence, the adoption of NSCs transplantation to replace lost cells and promote structural repair in cerebral infarction presents an ideal therapeutic strategy (Russo et al, 2018;Lyu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Extracellular vesicles from medicated plasma of Buyang Huanwu decoction-preconditioned neural stem cells accelerate neurological recovery following ischemic stroke

Long

Zhang

et al. 2023

Front. Cell Dev. Biol.

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Introduction: The neurological impairment of survivors after ischemic stroke poses a serious risk to their quality of life and health. Effective therapeutic options are still lacking. Neural stem cells (NSCs) promote neurogenesis via secreted extracellular vesicles (NSC-EVs), which would be a potential therapeutic option, but the insufficient quantity of NSC-EVs in vivo restrains clinical application. Buyang Huanwu Decoction (BHD), a classic traditional Chinese medicine (TCM) decoction, is promising to alleviate neurological impairment after ischemic stroke. It was speculated that BHD might promote neurological recovery through the NSC-EVs.Methods: The medicated plasma of BHD (MP-BHD) was prepared to precondition NSCs and isolate EVs (BHD-NSC-EVs). Middle cerebral artery occlusion (MCAO) models and primary NSCs were administered to evaluate the therapeutic effect. Next-generation sequencing was performed to explore the mechanism.Results: The BHD-NSC-EVs more significantly accelerated neurological recovery after MCAO and promoted NSCs proliferation and differentiation than BHD and NSC-EVs alone. MP-BHD enhanced the largescale generation of BHD-NSC-EVs, which encapsulated functional miRNA and may play critical roles in neurogenesis.Discussion: In replacing BHD or NSCs, the preconditioned NSC-EVs present a more efficient therapeutic strategy for ischemic stroke. Based on the clinical efficacy of TCM, the preconditioning of NSC-derived EVs via the MP of TCM herbs would presents a newly promising therapeutic strategy for neurological diseases.

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Current Understanding of the Neural Stem Cell Niches

Cited by 30 publications

References 270 publications

Vestibular Nuclei: A New Neural Stem Cell Niche?

Vestibular Nuclei: A New Neural Stem Cell Niche?

Intratendinious Versus Extracorporeal Knot Four Strand Core Suture Repair of Flexor Tendon Injuries of the Hand Zone II

Extracellular vesicles from medicated plasma of Buyang Huanwu decoction-preconditioned neural stem cells accelerate neurological recovery following ischemic stroke

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