Current Understandings on Complex Regional Pain Syndrome

Abstract

Abstract:The mechanisms underlying complex regional pain syndrome (CRPS) have been increasingly studied over the past decade. Classically, this painful and disabling disorder was considered to emerge from pathology of the central nervous system. However, the involvement of additional peripheral disease mechanisms is likely, and recently these mechanisms have also attracted scientific attention. The present article provides an overview of the current understandings regarding pathology of the autonomic and somatic nervous system in CRPS, as well as the roles of neurogenic inflammation, hypoxia, and the contribution of psychological factors. Potential connections between the separate disease mechanisms will be discussed. Additionally, currently known risk factors for CRPS will be addressed. Insight into risk factors is of relevance as it facilitates early diagnosis and tailored treatment. Moreover, it may provide clues for further unraveling of the pathogenesis and etiology of CRPS.

Physiotherapy Interventions and the Outcomes for Complex Regional Pain Syndrome (CRPS) Type 1 on the South Island of New Zealand – A Longitudinal, Prospective Case Series

“…education is an integral part of the Physiotherapist's conversation with any patient, yet the intervention of "education" was only recorded at most once a week. To obtain independent recorders of physiotherapy interventions was not possible for this study since it covered an area 150437 km 2 . Another potential recognised weakness of the study is the use of Likert scales for accurate statistical analysis of continuous variables.…”

“…CRPS may occur at the time of an injury, subsequent to an injury or occur spontaneously [2]. A distal predominance affecting the limbs with abnormal sensory, motor, sudomotor, vasomotor, and/or trophic findings is usual, with the syndrome showing variable progression over time [2 -5].…”

Radiofrequency therapy in back pain and complex regional pain syndrome

“…Multiple peripheral and central pathomechanisms are involved which maintain each other in terms of a vicious circle. 120,121 One mechanism is hypoxia, which may be induced by impaired microcirculation and vasoconstriction caused by endothelial dysfunction with altered ratio of the vasoactive substances NO and ET-1. 120,122 There is evidence for sterile 122 as well as for neurogenic inflammation.…”

Ailesel Kamptodaktili ve Periferik Nöropatili Üç Kız Kardeş

“…Usually, its onset is precipitated by a physical injury, for example, a fracture, sprain, or surgery. Sometimes no particular cause can be found, therefore, it is defined as idiopathic (4).…”