Current update on the diagnosis and management of head and neck soft tissue sarcomas

Tudor-Green, Ben; Fonseca, Felipe Paiva; Gomez, Ricardo Santiago; Brennan, Peter A.

doi:10.1111/jop.12555

Cited by 14 publications

(24 citation statements)

References 53 publications

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“…Previous studies that included a larger cohort of 12,755 patients mentioned that further data accumulation for predictors of HNS due to rare tumors and various histological subtypes is needed [1][2][3]. Indeed, Ketabachi et al had reported that the surgical margin was a survival predictor for 25 patients with HNS [7].…”

Section: Discussionmentioning

confidence: 99%

“…Head and neck sarcoma (HNS) is a rare malignancy, with more than 50 pathological subtypes, accounting for approximately 1% of all head and neck malignancies [1,2]. Surgery is the main treatment for patients who are newly diagnosed with HNS, while the e cacy of chemotherapy or radiotherapy remains debatable for all pathological subtypes of HNS [1][2][3]. The predictors for survival outcomes of HNS, such as overall survival, have been investigated by several previous studies [1][2][3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Age for Overall Survival in Head and Neck Sarcoma

Suzuki¹,

Takano²,

Tsukushi³

et al. 2020

Preprint

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Background：The association between age and survival outcomes in head and neck sarcoma (HNS) has yet to be fully investigated due to rare tumor. To research the association between age at surgery and survival outcomes of patients with HNS. Methods: Twenty-six patients with HNS who underwent by surgery from 2003 to 2017 were retrospectively enrolled. The association between clinicopathological parameters and age was assessed by Mann-Whitney U test, and the optimal cut-off age at surgery for predicting death was determined by receiver operating curve analysis. Log-rank test and Cox proportional hazards model were used for survival analyses.Results: Patients who did not undergo chemotherapy were significantly older age at surgery. Fifty-five was the cut-off age that predicted death. Shorter survival rates of overall, disease-specific, local recurrence-free and disease-free were associated with older age. Age (≥ 55 years/< 55 years) was correlated with shorter overall survival by multivariate analysis adjusting with chemotherapy (absence/presence). Conclusion: Older age predicts worse overall survival in HNS.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of Age for Overall Survival in Head and Neck Sarcoma

Suzuki¹,

Takano²,

Tsukushi³

et al. 2020

Preprint

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“…Malignant peripheral nerve sheath tumors are usually large lesions that may sometimes cause a fusiform expansion of the nerve from which they arise . Depending upon the stroma and cellularity, the tumors can be fibrous, gelatinous, or fleshy in consistency.…”

Section: Discussionmentioning

confidence: 99%

Malignant peripheral nerve sheath tumor of nasal cavity and paranasal sinus with 13 years of follow‐up—A case report and review of literature

Thomas

Abraham

Bhanat

et al. 2019

Clinical Case Reports

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“…Adds to the failure in the treatment of this case the difficulty of monitoring the vital structures involved by the tumor mass as well as the inability to remove it in its entirety surgically, which could have increased the chances of survival for the patient 18 .…”

Section: Discussionmentioning

confidence: 99%

Synovial sarcoma: case report

Ribeiro

Monteiro

Melo

et al. 2017

RGO, Rev. Gaúch. Odontol.

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RESUMOSarcomas sinoviais são neoplasias raras e agressivas, localizadas na região da cabeça e pescoço e geralmente ocorrem em adultos jovens. Relato do caso: este relato apresenta um caso de sarcoma sinovial em um paciente de 15 anos que procurou tratamento médico para sintomas dolorosos e associados à disfagia. A lesão era nodular, extensa, localizada na região da parótida e estendida à região cervical esquerda. O paciente foi tratado em um hospital de referência com um protocolo de tratamento que inicialmente incluiu quimioterapia por seis meses e cirurgia para tentar excisar a lesão, mas a cirurgia foi ineficaz porque a total remoção do tumor poderia comprometer estruturas vitais importantes. A tomografia computadorizada mostrou uma área hipodensa com crescimento difuso, sem envolvimento dos ossos faciais, e a análise histopatológica revelou células fusiformes pleomórficas e ovais, com células epiteliais arredondadas formando ninhos rodeados por tecido fibroso. A análise imunohistoquímica foi conclusiva para o diagnóstico de um sarcoma sinovial de alto grau na região cervical parotídea esquerda. A equipe médica optou pelo tratamento paliativo com radioterapia cervical. O paciente permaneceu hospitalizado por quatro meses após a cirurgia e faleceu 15 meses após o diagnóstico, devido à obstrução das vias aéreas pelo rápido crescimento tumoral residual. O sarcoma sinovial, quando diagnosticado tardiamente pode reduzir a sobrevida dos pacientes por causa de complicações que o crescimento do tumor pode trazer para o prognóstico e qualidade de vida.Termos de indexação: Quimioterapia de indução. Neoplasias. Sarcoma sinovial.

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Current update on the diagnosis and management of head and neck soft tissue sarcomas

Cited by 14 publications

References 53 publications

Impact of Age for Overall Survival in Head and Neck Sarcoma

Impact of Age for Overall Survival in Head and Neck Sarcoma

Malignant peripheral nerve sheath tumor of nasal cavity and paranasal sinus with 13 years of follow‐up—A case report and review of literature

Synovial sarcoma: case report

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