Current utilities of imaging in grading musculoskeletal soft tissue sarcomas

Radiomic analysis of soft tissues sarcomas can distinguish intermediate from high‐grade lesions

“…Grading of STSs is widely held as their main prognostic factor. The Fédération Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grading system is often used, taking into account the mitotic rate, the degree of necrosis and tumor differentiation . It applies to several histologies, but not to all of them, and indeed some histologies automatically correspond to a given grading, irrespective of those characteristics .…”

“…The entire dataset was divided in three groups: (i) the training set containing the data used to train the models (60% of the data); (ii) the validation set containing the data used to validate the model and to choose the best one (30% of the data); and (iii) the test set containing the data used to test the model and examine its behavior with never‐seen data (10% of the data), see the Statistical Analysis section. They had a histological diagnosis of STS of intermediate (5 patients) or high (14 patients) malignancy grade according to the FNCLCC (French Fédération Nationale des Centres de Lutte Contre le Cancer) system . The FNCLCC system is based on tumor differentiation, mitotic rate, and amount of tumor necrosis.…”

Applications of PET‐MRI in musculoskeletal disease

“…The addition of novel MRI techniques such as DWI with apparent diffusion coefficient (ADC) mapping, dynamic contrast enhancement (DCE), and MRS may improve diagnostic accuracy compared with conventional MRI . Combining these with metabolic measures such as standardized uptake values (SUV), total lesion glycoslysis (TLG), and metabolic tumor volume (MTV) provides powerful multiparametric evaluation.…”

“…There are clear advantages to combined PET and MRI for therapy response assessment and disease monitoring. The utility of FDG PET for response assessment after chemotherapy has been demonstrated for both STS and BS, and quantitative ADC analysis has been used to assess response on MRI . While it seems intuitive that combining PET and MRI would be additive or perhaps synergistic in determining treatment response, early studies have shown discordant results between PET and MRI measures, and further study is needed to examine the role of integrated PET‐MRI in assessing therapy response.…”

Diagnosis and Planning in the Management of Musculoskeletal Tumors - A Review

“…Percutaneous cement augmentation can be done a few days after the primary fusion procedure by the intervention radiologist. Augmenting the adjacent levels to the fusion decrease the chance of a compression fracture, due to increased stresses streses transferred from the fixed segment [10][11][12] .…”