Current views on metabolic syndrome

Svačina, Štěpán

doi:10.36290/vnl.2018.166

Cited by 5 publications

(1 citation statement)

References 11 publications

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“…In the context of metabolic syndrome and the IR, the TyG index and VAI index have been observed to predict all the male sexual dysfunctions with similar strength, including erectile dysfunction, sexual satisfaction, orgasm, desire, and general satisfaction in men. Metabolic syndrome, characterized by obesity and associated disorders, has been found to have adverse effects on blood vessels, leading to the development of cardiovascular and other systemic diseases [14]. Our ndings are consistent with the existing literature, as we observed a rising prevalence of obesity and its associated disorders among younger individuals in our study population [8].…”

Section: Discussionsupporting

confidence: 92%

Which is better to predict erectile dysfunction and male sexual function in the context of metabolic syndrome: Triglyceride-Glucose Index or Visceral Adiposity Index? A Retrospective Cross-sectional Study

Bolat,

Asci

et al. 2023

Preprint

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Background:Male sexual function is influenced by various factors, including metabolic disorders such as metabolic syndrome (MetS) and insulin resistance. We aimed to investigate the effects of two metabolic indices, the triglyceride-glucose (TyG) index and the visceral adiposity index (VAI), on erectile function and other aspects of male sexual function. Methods: A total of 400 men having erectile and ejaculatory dysfunction were included. Age, body weight and waist circumference (WC) were calculated and comorbidities and contributing factors such as diabetes mellitus, hypertension, atherosclerotic disease, smoking, and alcohol use were recorded. Hormonal analysis was performed using the enzyme-linked immunosorbent assay (ELISA) for total testosterone, prolactin, and estradiol. The male sex-specific VAI was calculated using the [(WC/39.68)+(1.88xMI)]x(TG/1.03)x(1.31/HDL) formula. The TyG index was calculated logarithmic formula: Ln (fasting triglycerides) x (fasting glucose) / 2] (9). The participants were given the Turkish-validated 15-item long-form of the International Index of Erectile Dysfunction (IIEF) questionnaire to fill. Ejaculatory function was assessed using male sexual health questionnaire (MSHQ) consisting of four questions. The participants completed the 21-item Beck Depression Inventory. Kolmogorov-Smirnov and Chi-square tests were used for normal distribution of continuous and categorical variables, respectively. The ROC analysis was used to evaluate the predictive abilities of TyG and VAI cut-off values for ED risk. Statistical significance was set at p < 0.05. Results: Both the TyG index and the VAI were significantly associated with ED. A higher TyG index and VAI were associated with an increased risk of ED. The presence of MetS further worsened sexual function, with lower scores in sexual satisfaction, orgasm, desire, and general satisfaction. The TyG index and VAI demonstrated similar predictive abilities for ED, as indicated by their respective area under the curve rates. Additionally, patients with MetS had poorer ejaculation quality compared to those without MetS. Conclusions: These findings highlight the potential of the TyG index and VAI as convenient tools for predicting and assessing sexual dysfunction in men, particularly in the context of metabolic disorders. Early detection and intervention for metabolic syndrome and insulin resistance may help mitigate their negative impact on male sexual function.

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Section: Discussionsupporting

confidence: 92%

Which is better to predict erectile dysfunction and male sexual function in the context of metabolic syndrome: Triglyceride-Glucose Index or Visceral Adiposity Index? A Retrospective Cross-sectional Study

Bolat,

Asci

et al. 2023

Preprint

View full text Add to dashboard Cite

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Which is better to predict erectile dysfunction and male sexual function in the context of metabolic syndrome: triglyceride–glucose index or visceral adiposity index?: a retrospective cross-sectional study

Bolat,

Dündar

et al. 2024

Int Urol Nephrol

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Proposal for standardizing normal insulin ranges in Brazilian patients and a new classification of metabolic syndrome

Chocair

Neves²,

Sato³

et al. 2022

Front. Med.

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BackgroundInsulin resistance and/or hyperinsulinemia are closely linked to adiposity, metabolic syndrome (MetS) and prolonged inflammatory processes.MethodsWe retrospectively analyzed 1,018 adult individuals with a mean age of 46 years (74% male) and classified them as: Metabolically normal: without any of the five criteria of the International Diabetes Federation (IDF) used for the diagnosis of MetS, plus normal fasting insulin (Men < 8 mU/L, Women < 10 mU/L); Level 1 MetS: with one or two IDF criteria, plus hyperinsulinemia (Men: ≥ 8 mU/L), and Women: ≥ 10 mU/L); Level 2 MetS: with three or more IDF criteria, plus hyperinsulinemia.ResultsThe mean values for fasting insulinemia in metabolically normal individuals was 4.6 ± 1.8 mU/L and 5.6 ± 2.3 mU/L, while their means for the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were 1.0 and 1.2 for men and women, respectively. In addition, the mean values for insulin (and HOMA-IR) for individuals with two normal anthropometric parameters (body mass index and waist girth), or two normal anthropometric parameters plus no IDF criteria, were similar to the metabolically normal group. Based on the obtained mean + 2 SD, we established the following insulin (and HOMA-IR) values as diagnostic cut-offs for hyperinsulinemia: Men: ≥ 8 mU/L (≥ 1.5), and Women: ≥ 10 mU/L (≥ 2.0). The mean serum insulin was significantly higher for individuals with Level 1 MetS (approx. 9 mU/L for both genders) compared with metabolically normal individuals, as was the prevalence of hepatic steatosis, which was more evident in men. Thus, the presence of one or two abnormal IDF criteria, combined with hyperinsulinemia and/or raised HOMA-IR, suggests the presence of MetS and insulin resistance. Patients of both genders with Level 2 MetS had higher serum insulin and/or HOMA-IR values than Level 1, as well as a higher prevalence of hypertension and hepatic steatosis, being more pronounced among men. The process was progressive and proportional to the degree of hyperinsulinemia.ConclusionIt is proposed that intervention against MetS progression should be started in individuals with Level 1 MetS, rather than waiting for more criteria for diagnostic confirmation, which this should help to reduce the occurrence of known complications such as type 2 diabetes, atherosclerosis, hypertension, and chronic kidney disease, among others.

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Current views on metabolic syndrome

Cited by 5 publications

References 11 publications

Which is better to predict erectile dysfunction and male sexual function in the context of metabolic syndrome: Triglyceride-Glucose Index or Visceral Adiposity Index? A Retrospective Cross-sectional Study

Which is better to predict erectile dysfunction and male sexual function in the context of metabolic syndrome: Triglyceride-Glucose Index or Visceral Adiposity Index? A Retrospective Cross-sectional Study

Which is better to predict erectile dysfunction and male sexual function in the context of metabolic syndrome: triglyceride–glucose index or visceral adiposity index?: a retrospective cross-sectional study

Proposal for standardizing normal insulin ranges in Brazilian patients and a new classification of metabolic syndrome

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