Curve progression in idiopathic scoliosis : 40-year follow-up from diagnosis

Dragsted, Casper; Ragborg, Lærke; Ohrt-Nissen, Søren; Andersen, Thomas Levin; Gehrchen, Martin; Dahl, Benny

doi:10.1016/j.bas.2022.101008

Cited by 3 publications

(5 citation statements)

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“…Ragborg et al 1,2 confirm that scoliosis is a life-long condition with potentially significant poor HRQoL scores many years after diagnosis, thus painting a much less rosy picture than previous reports.…”

Section: Providing Appropriate Continuing Carementioning

confidence: 92%

“…In this edition of the The Bone & Joint Journal, Ragborg et al 1,2 describe the very long-term quality of life outcomes of patients with juvenile or adolescent idiopathic scoliosis (JIS/AIS) who were treated surgically, with braces, and with observation. This paper is notable as there is a 71% follow-up rate over a 40-year period.…”

Section: Providing Appropriate Continuing Carementioning

confidence: 99%

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Long-term follow-up of patients with idiopathic scoliosis

Birch¹

2023

The Bone & Joint Journal

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Section: Providing Appropriate Continuing Carementioning

confidence: 92%

Section: Providing Appropriate Continuing Carementioning

confidence: 99%

Long-term follow-up of patients with idiopathic scoliosis

Birch¹

2023

The Bone & Joint Journal

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“…(3) The opposite limitation is also present: the ranges of the patients' Risser numbers, ages and curve sizes are too large. Some researchers find that a combination of bracing and exercise is differentially effective in AIS at different Risser numbers and this type of variability may apply to botulinum as well [4][5][6]. (4) Studies have found that bracing plus exercise substantially improve curves in AIS [41].…”

Section: Limitations Of the Studymentioning

confidence: 99%

“…When a Cobb angle measurement of a curve exceeds 25 degrees, braces are often implemented to deter progression, since this is the level at which most studies report the highest rates of progression [4][5][6][7]. However, several other systems may make different determinations.…”

Section: Introductionmentioning

confidence: 99%

“…Surgery has dominated the field of scoliosis since it rightfully has been recognized as the most reliable and effective remediation. The natural history of AIS suggests 0.4 to 2.2 degrees of annual progression, depending upon age, Risser number and curve; teenagers' spines are capable of much greater change, and great person-to-person variation exists [4][5][6]. When visiting their surgeon, young patients have an X-ray taken, and they and their families are told of the 45-degree threshold for surgery.…”

Section: Introductionmentioning

confidence: 99%

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Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis—A Randomized Pilot Study

Fishman

2024

Muscles

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Background: Approximately 90% of scoliosis cases are adolescent-idiopathic (AIS). From the first appearance of scoliosis at 10–14 years of age until the age of 18, the spine is most vulnerable to deterioration; young, growing people are most susceptible to the worsening of one or more scoliotic curves. An effective non-surgical means of remediation would be welcome. Design: This was a randomized, controlled, two-arm study assessing the safety and efficacy of combining incobotulinum injections with yoga to reverse lumbar and thoracolumbar AIS. Methods: In a private clinic setting, non-pregnant, healthy 12–18 year-olds were either taught a symmetrical “placebo” yoga pose (control sub-group 1), performed the side plank (Vasisthasana) three times daily with a placebo injection (control sub-group 2) or performed the three-times-daily side plank with a botulinum injection (intervention group 3). Injection: For the injection, 33 IU of incobotulinumtoxin type A (Xeomin) was injected into the concave-side lumbar paraspinals and quadratus lumborum at L2–3 and the psoas muscle at L3–4, or participants were injected similarly with a placebo. Randomization was achieved using random.org. Objective: The objective was to determine whether the treatment of muscular asymmetry with botulinum toxin injections and side planks is safe and effective in AIS. Results/Outcome: Eleven intervention and thirteen placebo patients (Groups 1 + 2), who were 12–18 years old, completed the three-month study. Mean daily side plank time = 165 s. The mean initial lumbar curvature was 36.9 degrees (SD 14.36), (p < 0.0001); the mean Group 3 curvature at 3 weeks was 29.5 degrees (SD 14.23) (p < 0.0001); and the mean Group 3 curvature at 3 months was 26.0 degrees (SD 12.81). Onset vs. 3-month value: p < 0.0001. Harms were limited to one patient in Group 2 and one in Group 3, who complained of transient shoulder pain and supported themselves temporarily on their forearm instead of the palm of the extended hand. Conclusion: Muscle strength asymmetry appears to be relevant to AIS treatment. Incobotulinum injections combined with side planks performed with the convex side downward may be more effective in reversing lumbar AIS than placebo exercises or side planks and placebo injections.

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Incobotulinumtoxin A and Yoga-Like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis – a Randomized Pilot Study

Fishman

2023

Preprint

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Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis – a randomized pilot study Abstract: Background: Approximately 90% of scoliosis is adolescent idiopathic (AIS). From its first appearance at 10-14 until age 18 it is most vulnerable to deterioration; young people are most susceptible to the condition worsening. An effective non-surgical means of remediation would be welcome. Design: Randomized control two-arm study, assessing the safety and efficacy of combining incobotulinum injections with yoga to reverse lumbar and thoracolumbar AIS. Methods: In a private clinic setting, non-pregnant healthy 12 – 18 year-olds were either taught a symmetrical “placebo” yoga pose (control sub-group 1), given the side plank (Vasisthasana) done thrice daily with placebo injection (control sub-group 2) or given the thrice-daily side-plank with botulinum injection (Intervention group 3). Injection: 33 IU of incobotulinum toxin type A (Xeomin) injected into concave-side lumbar paraspinals and quadratus lumborum at L2-3 and the psoas muscle at L3-4, or injected similarly with placebo. Randomization by Random.com. Objective: Assess whether muscular asymmetry treated with botulinum toxin injection and the side-plank are safe and effective in AIS.Results: Outcome: Twelve intervention and 12 placebo patients (Groups 1 + 2), 12 -18 years old completed the three-month study period. Mean daily side-plank time = 165 seconds. Mean initial lumbar curvature was 36.9 degrees (SD 14.36), (p<0.0001); mean curvature at 3 weeks was 29.5 degrees. (SD 14.23) (p<0.0001); mean curvature at 3 months was 26.0 degrees (SD 12.81) Onset vs 3-month value: p<0.0001. Two patients in Group 3 complained of shoulder pain, and 2 of wrist pain that resolved when the side-plank was done on the elbow. Conclusion: Muscle asymmetry appears relevant to AIS treatment. Incobotulinum injections combined with the side-plank done with the convex side downward may be safe and helpful in adolescent idiopathic lumbar scoliosis.

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Curve progression in idiopathic scoliosis : 40-year follow-up from diagnosis

Cited by 3 publications

References 0 publications

Long-term follow-up of patients with idiopathic scoliosis

Long-term follow-up of patients with idiopathic scoliosis

Incobotulinumtoxin A and Yoga-like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis—A Randomized Pilot Study

Incobotulinumtoxin A and Yoga-Like Isometric Exercise in Adolescent Idiopathic Lumbar Scoliosis – a Randomized Pilot Study

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