Curvularia lunata: A rare cause of black-grain eumycetoma

Gunathilake, Roshan; Perera, P.; Sirimanna, Ganga

doi:10.1016/j.mycmed.2013.09.005

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…Some of them, such as Curvularia lunata, C. hawaiiensis , and C. spicifera , however, are also considered as emerging agents of local and invasive human phaeohyphomycoses ( 1 ), i.e., infections caused by melanin producing molds. Curvularia species are frequently reported as agents of allergic fungal sinusitis and bronchopulmonary disease ( 2 – 4 ) but they can also be associated with mycotic keratitis ( 5 , 6 ), cutaneous and subcutaneous mycoses ( 7 , 8 ), and infections of the central nervous system ( 2 , 9 ). Deep and disseminated Curvularia infections have been described in both immunocompromised and immunocompetent patients ( 4 , 10 – 13 ).…”

Section: Introductionmentioning

confidence: 99%

Interaction of THP-1 Monocytes with Conidia and Hyphae of Different Curvularia Strains

et al. 2017

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Interaction of the human monocytic cell line, THP-1 with clinical isolates of three Curvularia species were examined. Members of this filamentous fungal genus can cause deep mycoses emerging in both immunocompromised and immunocompetent patients. It was found that monocytes reacted only to the hyphal form of Curvularia lunata. Cells attached to the germ tubes and hyphae and production of elevated levels of interleukin (IL)-8 and IL-10 and a low level of TNF-α were measured. At the same time, monocytes failed to produce IL-6. This monocytic response, especially with the induction of the anti-inflammatory IL-10, correlates well to the observation that C. lunata frequently cause chronic infections even in immunocompetent persons. Despite the attachment to the hyphae, monocytes could not reduce the viability of the fungus and the significant decrease in the relative transcript level of HLA-DRA assumes the lack of antigen presentation of the fungus by this cell type. C. spicifera and C. hawaiiensis failed to induce the gathering of the cells or the production of any analyzed cytokines. Monocytes did not recognize conidia of Curvularia species, even when melanin was lacking in their cell wall.

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Section: Introductionmentioning

confidence: 99%

Interaction of THP-1 Monocytes with Conidia and Hyphae of Different Curvularia Strains

et al. 2017

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Fungi Causing Eumycotic Mycetoma

van de Sande

2023

ClinMicroNow

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Eumycetoma was recognized as a neglected tropical disease by the World Health Organization in 2016. All fungi known to cause eumycetoma belong to the phylum Ascomycota. Madurella mycetomatis is the most common fungal causative agent of eumycetoma. Medicopsis romeroi is a coelomycetous anamorphic fungus. It might be misidentified as Trematosphaeria grisea when cultures lack pycnidia. Neotestudina rosatii has been isolated from soil from tropical countries; it is an ascomycete with spherical, deliquescent asci and rhomboid ascospores with one septum each. The genus Scedosporium comprises a small group of rather variable species. Magnetic resonance imaging and radiology are often used to identify the limits of the lesions and to determine if bone is affected. Antibody detection tests created in‐house have been used in some locations where eumycetoma is endemic.

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