CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo–Photothermal Therapy

Jiang, Wei; Zhang, Huiyuan; Wu, Jilian; Zhai, Guangxi; Li, Zhonghao; Luan, Yuxia; Garg, Sanjay

doi:10.1021/acsami.8b13487

Cited by 157 publications

(78 citation statements)

References 51 publications

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“…The nanomaterial also had good targeting properties. In addition, as an active targeting agent, folic acid−Bovine serum albumin (FA−BSA) was modified on ZIF-8, which was also loaded with CuS and quercetin ( Figure 4) [90]. The nano-platform can actively transport the photothermal agent and the chemotherapeutic drug to the cancer tissue.…”

Section: Multi-targeted Response Of Mof Nanomaterials For Anticancer Tmentioning

confidence: 99%

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Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

et al. 2020

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In recent years, metal organic frameworks (MOFs) have been widely developed as vehicles for the effective delivery of drugs to tumor tissues. Due to the high loading capacity and excellent biocompatibility of MOFs, they provide an unprecedented opportunity for the treatment of cancer. However, drugs which are commonly used to treat cancer often cause side effects in normal tissue accumulation. Therefore, the strategy of drug targeting delivery based on MOFs has excellent research significance. Here, we introduce several intelligent targeted drug delivery systems based on MOFs and their characteristics as drug-loading systems, and the challenges of MOFs are discussed. This article covers the following types of MOFs: Isoreticular Metal Organic Frameworks (IRMOFs), Materials of Institute Lavoisier (MILs), Zeolitic Imidazolate Frameworks (ZIFs), University of Oslo (UiOs), and MOFs-based core-shell structures. Generally, MOFs can be reasonably controlled at the nanometer size to effectively achieve passive targeting. In addition, different ligands can be modified on MOFs for active or physicochemical targeting. On the one hand, the targeting strategy can improve the concentration of the drugs at the tumor site to improve the efficacy, on the other hand, it can avoid the release of the drugs in normal tissues to improve safety. Despite the challenges of clinical application of MOFs, MOFs have a number of advantages as a kind of smart delivery vehicle, which offer possibilities for clinical applications.

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Section: Multi-targeted Response Of Mof Nanomaterials For Anticancer Tmentioning

confidence: 99%

“…Schematic illustration of the combinational therapy platform based on folic acid (FA)−bovine serum albumin (BSA)-modified ZIF-8 (FA−BSA/CuS@ZIF-8-QT)[90]. Reprinted (adapted) with permission from (CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo-Photothermal Therapy).…”

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confidence: 99%

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

et al. 2020

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“…It exerts various biological effects including antioxidant, anticancer, anti-inflammatory, anti-aggregatory, anti-aging effects (Iskender et al, 2017). Que is non-toxic and safe to animals, even at high doses (4000 mg/day), which makes it safe for dietary intake (Jiang et al, 2018). Indeed, Que has been used as a drugstore medicine in certain countries.…”

Section: Introductionmentioning

confidence: 99%

Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury

Zhang

Wang

2020

Front. Physiol.

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Quercetin has attracted more attention in recent years due to its protective role against ischemia/reperfusion injury. Quercetin can alleviate oxidative stress injury through the inhibition of NADPH oxidase and xanthine oxidase, blockage of the Fenton reaction, and scavenging of reactive oxygen species. Quercetin can also exert anti-inflammatory and anti-apoptotic effects by reducing the response to inflammatory factors and inhibiting cell apoptosis. Moreover, it can induce vasodilation effects through the inhibition of endothelin-1 receptors, the enhancement of NO stimulation and the activation of the large-conductance calcium-activated potassium channels. Finally, Quercetin can also antagonize the calcium overload. These multifaceted activities of Quercetin make it a potential therapeutic alternative for the treatment of ischemia/reperfusion injury.

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“…35 Advantages of using nanoparticles including the delivery of drugs and genes into various specific sites of the body could result in longer shelf-life of the drug at the target site, and improvement of intracellular absorption, and further, the stability of drugs has also been discussed. 8,[36][37][38] Furthermore, targeted drug delivery through nanoparticles provides a new therapeutic approach, in which a drug that has been administered through intravenous or oral routes acts effectively, with lower side effects in the patient. [39][40][41][42] Nanohydrogels have shown different characteristics, making them an excellent vehicle for the delivery of therapeutic agents.…”

Section: Introductionmentioning

confidence: 99%

<p>Biocompatibility, Cytotoxicity, Antimicrobial and Epigenetic Effects of Novel Chitosan-Based Quercetin Nanohydrogel in Human Cancer Cells</p>

Abbaszadeh¹,

Rashidipour²,

Khosravi³

et al. 2020

IJN

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Background: Previous studies have reported that quercetin (Q) has a potential antibacterial and anticancer activity. However, its application is limited by many important factors including high hydrophobicity and low absorption. Methodology: In the current study, we synthesized and characterized (Patent) a novel chitosan-based quercetin nanohydrogel (ChiNH/Q). Encapsulation efficiency was confirmed by UV/VIS spectrophotometer. Physicochemical characterization of ChiNH/Q was assessed by PDI, DLS, SEM, FTIR, and XRD. The toxicity of the ChiNH/Q against five strains of the pathogen and HepG2 cells was examined. Moreover, the quantification of ChiNH/Q on genomic global DNA methylation and expression of DNMTs (DNMT1/3A/3B) in HepG2 cancer cells were evaluated by ELISA and real-time PCR, respectively. Results: Under the SEM-based images, the hydrodynamic size of the ChiNH/Q was 743.6 nm. The changes in the PDI were 0.507, and zeta potential was obtained as 12.1 mV for ChiNH/Q. The FTIR peak of ChiNH/Q showed the peak at 627 cm −1 corresponded to tensile vibrational of NH 2-groups related to Q, and it is the indication of Q loading in the formulation. Moreover, XRD data have detected the encapsulation of ChiNH/Q. The ChiNH/Q showed a potent antimicrobial inhibitory effect and exerted cytotoxic effects against HepG2 cancer cells with IC 50 values of 100 µg/mL. Moreover, our data have shown that ChiNH/Q effectively reduced (65%) the average expression level of all the three DNMTs (p<0.05) and significantly increased (1.01%) the 5-methylated cytosine (5-mC) levels in HepG2 cells. Conclusion: Our results showed for the first time the bioavailability and potentiality of ChiNH/Q as a potent antimicrobial and anticancer agent against cancer cells. Our result provided evidence that ChiNH/Q could effectively reduce cellular DNMT expression levels and increase genomic global DNA methylation in HepG2 cancer cells. Our results suggest a potential clinical application of nanoparticles as antimicrobial and anticancer agents in combination cancer therapy.

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CuS@MOF-Based Well-Designed Quercetin Delivery System for Chemo–Photothermal Therapy

Cited by 157 publications

References 51 publications

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Metal Organic Frameworks as Drug Targeting Delivery Vehicles in the Treatment of Cancer

Protective Mechanisms of Quercetin Against Myocardial Ischemia Reperfusion Injury

<p>Biocompatibility, Cytotoxicity, Antimicrobial and Epigenetic Effects of Novel Chitosan-Based Quercetin Nanohydrogel in Human Cancer Cells</p>

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