Cushing's Syndrome Associated With a Suprasellar Tumour

Krieger, D. T.; Krieger, Howard P.; Soffer, Louis J.

doi:10.1530/acta.0.0470185

Cited by 7 publications

(5 citation statements)

References 12 publications

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“…In the present patient, the presence of subnormal responsiveness to ACTH, metyrapone and Pitressin@, absence of normal dexamethasone suppressability, absence of normal corticosteroid circadian periodicity, and initially markedly elevated plasma ACTH concentration, are in keeping with the majority of reports cited both for ACTH producing pituitary tumours (Krieger et al, 1964;Nelson et al, 1966) and ectopic ACTH producing tumours (Engel & Kehane, 1963;Liddle et al, 1963;O'Riordan et al, 1966;Friedman et al, 1966;Landon et al, 1967;Strott et al, 1968;Melvin et al, 1970;Marks et al, 1975).…”

Section: Discussionsupporting

confidence: 90%

“…The distinction may be more than academic. Of sixteen cases of 'primary' tumour examined pathologically, two were chromophobe adenomas, and the remainder pituitary carcinomas, six of which showed evidence of metastases (Krieger et al, 1964). In all the 'secondary' cases, except one reported as a transitional basophilic carcinoma (Myerson & Hingston, 1962), the pathology of the pituitary tumour has been that of an adenoma, usually chromophobe in nature.…”

Section: Discussionmentioning

confidence: 98%

“…In most instances the pituitary tumour was recognized only after subtotal or total adrenalectomy had been performed ('secondary' pituitary tumour). In a smaller group, the pituitary tumour was noted with the onset of the Cushing's syndrome (Krieger et al, 1964) and considered as 'primary' tumours, although it is recognized that such undetected tumours may have existed in the secondary group prior to surgery.…”

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confidence: 99%

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The Characterization of the Acth Produced by a Primary Pituitary Tumour in a Patient With Cushing's Disease

Krienger

Choi

Anderson

1976

Clinical Endocrinology

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The nature of ACTH present in pituitary tumours associated with Cushing's disease has not been previously characterized nor correlated with the electron microscopic appearance. The present report describes the culture of tumour tissue obtained from a patient with a pituitary tumour associated with Cushing's disease, and the characterization of the ACTH content of tumour and media by bioassay, immunoassay, and Sephadex G-50 gel filtration. Electron microscopic studies were also performed. The pathological diagnosis was pituitary adenoma with basophilic PAS-positive granules. Electron microscopy showed uniformity of size and shape of the tumour cells, the presence of secretory granules of varying size and density, and disorganized tubular and vacuolar arrays of endoplasmic reticulum. The bioreactive ACTH content of the tumour was 0-29 mug/g, which is markedly below that seen in the normal pituitary, but within the range reported for ectopic ACTH-producing tumours. Immunoreactive ACTH when measured by a C-terminal antibody was five-fold higher than when measured by an N-terminal antibody; the latter gave a value of 1-24 mjg/g. On Sephadex G-50 gel filtration, 9% of the N-terminal immunoreactivity was present in the Vo fraction ('big' ACTH). This latter fraction had a greater percentage of bioreactivity (28%) than previously reported for this molecular species. Analysis of the tumour culture medium revealed a variation in molecular size similar to that seen in the tumour, although the percentage of ACTH of large molecular size was greater, suggesting increased secretion of a possible 'prohormone' by the tumour. Plasma ACTH was characterized by a 2:1 ratio of immunoreactivity (N-terminal) to bioreactivity, and a 4:1 ratio of C-terminal/N-terminal immunoreactivity. This report also appears to be the first of successful short-term tissue culture of a primary ACTH-producing tumour. The granule size was considerably larger than that reported for normal pituitary ACTH-containing cells.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

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The Characterization of the Acth Produced by a Primary Pituitary Tumour in a Patient With Cushing's Disease

Krienger

Choi

Anderson

1976

Clinical Endocrinology

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“…1673 Das auf den Künstler projizierte "Außenseitertum" entwickelte sich bereits seit der italienischen Renaissance. 1674 Die Vorstellung vom künstlerisch-pathologischen Ausbruch aus den Strukturen der Gesellschaft führt zurück zur Diskussion über die "Bürgerlichkeit" (siehe Kapitel 2), wobei die radikale Abwendung der Künstler vom "Bürgertum" ab dem 19. Jahrhundert einsetzte.…”

Section: Mythenbildung Iii: Künstlerkult Der Moderneunclassified

Kurt Schwitters' Weg zur "Merz"-Kunst

Campe¹

2022

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An dieser Stelle möchte ich allen beteiligten Personen meinen großen Dank aussprechen, die mich bei der Anfertigung meiner Dissertation unterstützt haben. Mein besonderer Dank gilt meinem Doktorvater Prof. Dr. Thomas Noll für die enorme Unterstützung seit Beginn meiner Auseinandersetzung mit Schwitters' Frühwerk. Diese intensive Zusammenarbeit ermöglichte den stetigen Fortschritt meiner Arbeit unter Berücksichtigung verschiedener wissenschaftlicher Perspektiven. Auch möchte ich mich bei Prof. Dr. Carsten-Peter Warncke bedanken, der die Arbeit als Zweitbetreuer sowie mein Studium seit Beginn beinahe bis zum Schluss begleiten konnte. Prof. Dr. Heike Sahm übernahm freundlicherweise das Zweitgutachten, als Prof. Dr. Warncke dies nicht möglich war. Dafür möchte ich Prof. Dr. Sahm meinen besonderen Dank aussprechen, die durch ihr großes Interesse, ihre kritische Auseinandersetzung mit meiner Arbeit und ihre wissenschaftliche Perspektive meine Dissertation sowie deren interdisziplinären Ansatz stützte. Des Weiteren möchte ich Prof. Dr. Michael Thimann für seine aktive Teilnahme an der Disputation bedanken. Für ihre Beiträge zur Diskussion meiner Arbeit danke ich den Teilnehmenden des Forschungskolloquiums im Kunstgeschichtlichen Seminar der Georg-August-Universität Göttingen. Dr. Isabel Schulz danke ich für die freundlichen und wertvollen Auskünfte sowie die Bereitstellung des Bildmaterials aus dem Kurt Schwitters Archiv im Sprengel Museum Hannover. Außerdem möchte ich Dr. Gerson H. Jeute, Vanessa Erstmann VIII Danksagung sowie Katrin Januschke, für ihre aufschlussreichen Informationen, ihre professionellen Einschätzungen und den jeweiligen freundlichen und ausführlichen Austausch per E-Mail danken, der insbesondere während der Pandemie hilfreich war. Auch den Beiträgen sowie dem Austausch während des Symposiums "100 Jahre Merz. Kurt Schwitters. Crossmedia" im Sprengel Museum Hannover, das im Jahr 2019 mit einer entscheidenden Phase meiner Dissertation zusammenfiel, verdanke ich wichtige Einblicke. Ich bedanke mich herzlich bei mehreren ehemaligen Kommilitoninnen, u.a. Rieke Dobslaw und Marie Isabell Wetcholowsky, die während der Phase der Promotion ihre Perspektiven in Gesprächen und zu einzelnen Aspekten eingebracht haben. Hervorheben möchte ich dabei meinen Dank an Maike Kamp und Linda Kirschey für ihre Unterstützung bei meiner Promotion sowie ihre langjährige Freundschaft seit dem Studium. Nicht zuletzt bedanke ich mich bei meiner Mutter Hildegard von Campe, meinem Bruder Ulrich von Campe und meinem Vater Helmuth von Campe, die mich während des Studiums und der Promotion in jeder möglichen Form stets unterstützt und mir verlässlichen Rückhalt geboten haben. Zudem möchte ich Eric Lamvers meinen Dank äußern, der durch seine produktiven Anregungen und in zahlreichen Gesprächen meine Promotion intensiv begleitet hat.

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“…Terms like "Pre-Projectile Point" or "Non-Projectile Point" have been used associating the lack of reduction patterning with a lack of tool needs (cf. Elder, 1982;Glennan, 1972Glennan, , 1974Glennan, , 1976Krieger, 1964;Leakey et al, 1968;Nakamura, 1991Nakamura, [1966; Simpson, 1958Simpson, , 1976. Most archaeologists did not give credence to Paleolithic components, but nevertheless felt obligated to address the issue, highlighting the uncertainties underlying much of the scholarly discourse.…”

Section: A Mojave Desert Case Studymentioning

confidence: 99%

The Exploded Fine-Grained Volcanic Sources of the Desert West and the Primacy of Tool Function in Material Selection

Duke

2013

North American Archaeologist

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Fine-grained volcanic (FGV) procurement sites in western North America are examined with regard to the apparent preference for their use over alternatives that would conventionally be considered higher quality. A flintknapping experiment is described that addresses this issue, and the results are discussed in light of functional requirements in prehistoric, especially Paleoindian, technologies. Variability in the selection of FGV material is found to be based on strength and durability and can be seen to change according to textural differences. A case is made for reasserting the importance of function as critical to understanding the economics of lithic resource use. Particular emphasis is placed on how functional requirements interact with transport concerns in mobile toolkits. Data indicators are described that can be used to distinguish these priorities, and several Great Basin archaeological examples are provided.Combining functional with technological and formal aspects of lithic remains should increasingly enable us to approach questions of broader anthropological concern.

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Cushing's Syndrome Associated With a Suprasellar Tumour

Cited by 7 publications

References 12 publications

The Characterization of the Acth Produced by a Primary Pituitary Tumour in a Patient With Cushing's Disease

The Characterization of the Acth Produced by a Primary Pituitary Tumour in a Patient With Cushing's Disease

Kurt Schwitters' Weg zur "Merz"-Kunst

The Exploded Fine-Grained Volcanic Sources of the Desert West and the Primacy of Tool Function in Material Selection

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