Cushing syndrome secondary to a mediastinal carcinoid tumor: a case report

Ershadi, Reza; Vahedi, Matin; Jahanbin, Behnaz; Sarbazzadeh, Javad; Rafieian, Shahab

doi:10.1007/s13691-022-00542-1

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Cushing syndrome has been described in cases of a type of NET, carcinoid; carcinoid tumours are the most common cause of cyclical Cushing syndrome due to ectopic ACTH secretion [ 3 , 130 , 136 ]. Carcinoid tumours produce biogenic amines, of which serotonin is used as a screening tool.…”

Section: Other Testsmentioning

confidence: 99%

Pitfalls in the Diagnosis and Management of Hypercortisolism (Cushing Syndrome) in Humans; A Review of the Laboratory Medicine Perspective

Flowers

Shipman

2023

Diagnostics

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Biochemical confirmation of a diagnosis of hypercortisolism (Cushing syndrome) is vital to direct further investigations, especially given the overlap with non-autonomous conditions, such as pseudo-Cushing, and the morbidity associated with missed diagnoses. A limited narrative review was performed focusing on the laboratory perspective of the pitfalls of making a biochemical diagnosis of hypercortisolism in those presenting with presumed Cushing syndrome. Although analytically less specific, immunoassays remain cheap, quick, and reliable in most situations. Understanding cortisol metabolism can help with patient preparation, specimen selection (e.g., consideration of urine or saliva for those with possible elevations of cortisol binding globulin concentration), and method selection (e.g., mass spectrometry if there is a high risk of abnormal metabolites). Although more specific methods may be less sensitive, this can be managed. The reduction in cost and increasing ease of use makes techniques such as urine steroid profiles and salivary cortisone of interest in future pathway development. In conclusion, the limitations of current assays, particularly if well understood, do not impede diagnosis in most cases. However, in complex or borderline cases, there are other techniques to consider to aid in the confirmation of hypercortisolism.

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Section: Other Testsmentioning

confidence: 99%