Cuspidate A, new anti-fungal triterpenoid saponin from <i>Lepidagathis cuspidata</i>

Rattan, Rajeev; Fozdar, Bharat Inder; Gautam, Veena; Sharma, Ritika; Kumar, Dinesh; Sharma, Upendra

doi:10.1080/14786419.2016.1244192

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…Clémontanoside-C was recognised as compound 2. This plant is used as a fever reducer, antioxidant, antifungal, and anti-inflammatory agent, anti-oral ulcer treatment, and wound healer [48,49].…”

Section: Fig 4: Lepidagathis Cuspidate [53]mentioning

confidence: 99%

Genus Lepidagathis (Acanthaceae): Review of Its Ethanobotany, Phytochemistry and Pharmacological Potential

Ponnusamy

BALAKRISHNAN

2023

Int J Pharm Pharm Sci

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Almost all societies have employed medicinal plants as a source of medicine. Due to their natural origin, low cost, and lack of side effects, traditional medicinal plants have become increasingly popular over the past few decades. The Vedas and the Bible both mention the common usage of herbal medicines and healthcare products. People have used medicinal plants for thousands of years to flavour and preserve food, cure health problems, and prevent disease. Acanthaceae plant species are valued for their cultural and economic significance in horticulture and traditional medicine worldwide due to their wide range of medicinal characteristics. It was discovered that 87% of therapeutic drugs were made from naturally occurring substances taken from plants. In addition to being utilized as food, medicine, or ornamentals, plant species in this family also contain a variety of vital secondary metabolites, such as alkaloids, terpenoids, tannins, quinones, and flavonoids. The ethnopharmacological drugs of this class are utilised in many South and East Asian countries. According to some studies, Acanthaceae may possess antiviral, antifungal, cytotoxic, anti-inflammatory, antipyretic, hepatoprotective, immunomodulatory, and antiplatelet aggregation properties. The current review identifies some salient traits of a few significant genera in this family and explores how they are used in both traditional and creative ways in modern society. By keeping these factors in mind, the current study will be helpful for future research and clinical trials in the study of some new significant plant species that belong to this significant family.

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Section: Fig 4: Lepidagathis Cuspidate [53]mentioning

confidence: 99%

Genus Lepidagathis (Acanthaceae): Review of Its Ethanobotany, Phytochemistry and Pharmacological Potential

Ponnusamy

BALAKRISHNAN

2023

Int J Pharm Pharm Sci

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“…These microorganisms were conserved by sub-culturing in nutrient agar medium. Antimicrobial assay of these compounds were studied through agar diffusion technique by determining zone of inhibition [17][18][19]. Prior to activity, petri dishes were sterilized at 160 °C for 1.5 h in hot air oven.…”

Section: Determination Of Zone Of Inhibitionmentioning

confidence: 99%

Synthesis and biological evaluation of triphenyl-imidazoles as a new class of antimicrobial agents

et al. 2018

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Newer triphenyl-imidazole derivatives (4a-h) were synthesized in good yields by the reaction of benzil and substituted benzaldehydes in equimolar quantities and refluxing the product with acetyl chloride thereafter. Structures were confirmed by using FT-IR, 1H NMR and 13C NMR spectroscopic methods. All the synthesized compounds were tested for their antimicrobial activity using agar diffusion technique against Gram positive (Staphhylococcus aureus and Bacillus subtilis), Gram negative (Escherichia coli and Pseudomonas aureginosa) as well as Fungal strain (Candida albicans). Interestingly compounds 4a, 4b, 4f and 4h showed significant antibacterial activity, whereas compound 4b was found to have remarkable activity against the fungal strain. The Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of most active compounds were determined by broth dilution method and compound 4b emerged to have potent activities against most of the strains having MIC in the range of 25-200 µg/mL. To check the possible toxicities of the most active compounds, they were orally administered in rats and the concentration of liver enzymes serum glutamic-oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase (ALKP) were determined. Compound 4h showed significant increase in the enzymes level depicting the hepatotoxicity. The structure-activity relationship studies showed the importance of electron withdrawing groups at the distant phenyl ring at ortho and para positions as the compounds having chloro or nitro at these positions tend to be more active than the compounds with electron releasing groups such as methoxy. These compounds may act as lead compounds for further studies and appropriate modification in their structure may lead to agents having high efficacy with lesser toxicity.

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Sacha inchi (Plukenetia volubilis L.): An emerging source of nutrients, omega-3 fatty acid and phytochemicals

et al. 2022

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Cuspidate A, new anti-fungal triterpenoid saponin from Lepidagathis cuspidata

Cited by 7 publications

References 15 publications

Genus Lepidagathis (Acanthaceae): Review of Its Ethanobotany, Phytochemistry and Pharmacological Potential

Genus Lepidagathis (Acanthaceae): Review of Its Ethanobotany, Phytochemistry and Pharmacological Potential

Synthesis and biological evaluation of triphenyl-imidazoles as a new class of antimicrobial agents

Sacha inchi (Plukenetia volubilis L.): An emerging source of nutrients, omega-3 fatty acid and phytochemicals

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