With increasing human-induced environmental degradation, women's nature-based livelihood activities are threatened. In semi-arid northern Ghana, shea processing (i.e., shea butter, a derivative of shea nut from the shea tree), a vital women-dominated economic activity, is at risk as naturally occurring shea trees continue to decline in numbers and productivity. The decline of the shea tree's number and productivity and the ensuing biodiversity loss have sparked conservation efforts by governments and local communities. This includes community-led conservation models, which have recently gained traction in the Global South. Ghana implemented the Community Resource Management Areas (CREMA)—a community-led conservation model to improve biodiversity and ecosystem services, including shea trees conservation in response to climate change. Research has not explored the impacts of community-led conservation efforts on women’s nature-based livelihoods in Ghana. Using a mixed-methods approach involving surveys (n = 517) and focus group discussions (n = 8), this study explored shea productivity outcomes under CREMAs. Findings show that women residing in CREMAs had significantly better shea harvesting outcomes than those outside CREMAs (α = −53.725; P < 0.01). These findings demonstrate the potential for targeted conservation initiatives that are community-led, such as the CREMAs, to improve the conservation of economically significant naturally occurring trees like Shea. With the increasing impacts of climate change and environmental degradation, such models would be instrumental in achieving sustainable development goals like SDG5-gender equality, SDG10-reduced inequalities, SDG13-Climate action, SDG14-life below water, and SDG14-life on land.