Customized in Situ Functionalization of Nanodiamonds with Nanoparticles for Tuned (Bio)Sensing Platforms

Abstract

The incorporation of nanomaterials on (bio)sensors based on composite materials has led to important advances in analytical chemistry field due to the extraordinary properties that these materials offer. Nanodiamonds (NDs) are a novel type of material that has raised much attention, as they have the possibility of being produced on large scale by using relatively inexpensive synthetic methodologies. Moreover, NDs present some other interesting features as suitability for fluorescence due to surface functionalization and a proved biocompatibility, which makes them well suited for biomedical applications. In addition, NDs can be modified with metallic nanoparticles (NP), such as silver or gold, in order to combine the special features of both. The aim of this research work is the nanostructuration of novel sensing devices using NDs combined with silver (Ag@NDs) and gold (Au@NDs) nanoparticles. A complete morphological and electrochemical characterization as function of the prepared nanocomposite composition have been performed in order to improve the electroanalytical properties of the developed (bio)sensors.

Immunomodulatory effects of laser-synthesized nanodiamonds on peripheral blood mononuclear cells: evaluation of unconjugated, PEGylated, and antibody-conjugated formulations

“…Conversely, many potential applications of NDs seek to minimize or eliminate the immune response to particles so that the latter can perform a particular function unimpeded. Examples include intravenous injection of functionalized fluorescent NDs for bioimaging (Kaçar and Erden, 2020;Montes et al, 2020;van der Laan et al, 2020;Lin et al, 2022;Sharmin et al, 2022;Li et al, 2023) or accumulation of functionalized NDs around damaged tissues (e.g., cardiac, neural) to induce stem-cell repair (Ansari et al, 2016;Alexander et al, 2019;Taylor et al, 2019;Liu et al, 2021).…”