Customized Minimally Invasive Protocols for the Clinical and Microbiological Management of the Oral Microbiota

Scribante, Andrea; Butera, Andrea; Alovisi, Mario

doi:10.3390/microorganisms10040675

Cited by 27 publications

(7 citation statements)

References 10 publications

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“…These observational data provide strong evidence of the role of diet quality in clinical periodontitis and potentially an increased emphasis on addressing these deficiencies in routine dental care. Furthermore, our findings add to the body of literature showing several other emerging therapies, such as using ozonated compounds in gel may reduce periodontitis in diabetes patients [33].…”

Section: Discussionsupporting

confidence: 64%

The Associations of Cardiometabolic and Dietary Variables with Clinical Periodontitis in Adults with and without Type 2 Diabetes: A Cross-Sectional Study

Basu,

Richardson,

Carlos

et al. 2023

Nutrients

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Periodontitis is a commonly occurring inflammatory oral disease affecting a large proportion of global and US adults and is characterized by the destruction of the tooth-supporting apparatus. Its etiology is multifactorial, and type 2 diabetes and diet play critical roles in its remission and progression. However, few studies have addressed nutritional and serum vitamin D status in adults with periodontitis in the presence of diabetes. A cross-sectional study (n = 78), and a sub-set of age- and BMI-matched case–control studies (n = 50), were conducted to examine differences in dietary and cardiometabolic variables, and serum vitamin D in adults with periodontitis with or without diabetes. Participants provided fasting blood samples and 24-h diet recalls on at least two different days. Data on health history, body weight, height, nutritional habits, and clinical features of periodontitis were also collected. The Mann–Whitney U Test (with exact p-value estimation by Monte Carlo simulation) was used to examine differences by diabetes status in continuous and ordinal variables. Results revealed significantly lower serum vitamin D, and dietary intake of fruits, vegetables, dairy, vitamins A and C in adults with periodontitis with vs. without diabetes in the sub-study (all p < 0.05). In the overall sample, adults with diabetes presented with higher caries risk measures and lower numbers of teeth than those without diabetes; plaque and bleeding scores did not differ by diabetes status. Finally, a significant associations of food habits was observed, especially consuming protein-rich foods twice a day with a lower bleeding score, and daily consumption of fried or fast foods with a fewer number of teeth present (all p < 0.05). The present findings show significant dietary and serum vitamin D inadequacies among adults with periodontitis, and diabetes further aggravates the observed malnourishment and oral health.

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Section: Discussionsupporting

confidence: 64%

The Associations of Cardiometabolic and Dietary Variables with Clinical Periodontitis in Adults with and without Type 2 Diabetes: A Cross-Sectional Study

Basu,

Richardson,

Carlos

et al. 2023

Nutrients

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“…Para probiotics are inactivated microbial cells that offer health benefits without posing health risks. They can regulate the immune system, combat pathogens, and exhibit anti-inflammatory, antiproliferative, and antioxidant properties [19,41]. Furthermore, future studies could delve deeper into the specific mechanisms underlying the beneficial effects of probiotics and para probiotics.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, there has been a shift toward minimally invasive protocols for maintaining a balanced oral microbiota. These protocols include the use of probiotics and Para probiotics to rebalance oral flora, glycine and erythritol-based powders to target specific bacteria, and ozone therapy for its antibacterial and healing properties [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of lactobacillus reuteri-derived probiotic nano-formulation on recurrent aphthous stomatitis: a double-blinded randomized clinical trial

Samiraninezhad,

Kazemi,

Rezaee

et al. 2023

BMC Oral Health

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Objectives We aimed to assess the therapeutic effects of a topical probiotic nano-formulation derived from Lactobacillus reuteri on treating recurrent aphthous stomatitis. Materials and methods 60 participants were randomly allocated into two groups (control and probiotic). Probiotic group administered topical probiotic nano-formulation three times a day for seven days. The control group administered a standard analgesic oral rinse. The size of ulcer(s) and pain severity were recorded on days 0, 3, 5, and 7 after intervention. Results Before the intervention, the groups had no significant differences in terms of pain severity (P-value = 0.28) and lesion size (P-value = 0.24). Both groups exhibited significant reductions in pain severity and lesion size over the course of the intervention. After one week, the probiotic group had a notably larger lesion size reduction than the control group (P-value = 0.01). The probiotic group also showed a significantly greater reduction in pain severity than the control group (P-value = 0.04). Conclusions Applying topical probiotic nano-formulation derived from Lactobacillus reuteri three times a day decreased lesion size and pain severity in RAS patients faster than the local analgesic oral rinse. Clinical relevance Lactobacillus reuteri-derived probiotic nano-formulation might be a promising treatment option for RAS.

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“…Numerous studies have revealed the impact of oral microbiome on oral and systemic health, and explored its role in disease diagnosis and treatment. For example, some personalized treatments taking into account the systemic risk of the patients has provided new therapeutic strategies in periodontal and caries pathologies preventions, using new professional protocol or domiciliary use of probiotics [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Sjogren’s syndrome and high sugar diet on oral microbiome in patients with rampant caries: a clinical study

Tang,

Nie,

Zhang

et al. 2024

BMC Oral Health

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Objective The purpose of this study was to assess the composition of the oral microbial flora of adults with rampant caries in China to provide guidance for treatment. Patients and methods Sixty human salivary and supragingival plaque samples were collected. They were characterized into four groups: patients with rampant caries with Sjogren’s syndrome (RC-SS) or high-sugar diet (RC-HD), common dental caries (DC), and healthy individuals (HP). The 16S rRNA V3-V4 region of the bacterial DNA was detected by Illumina sequencing. PCoA based on OTU with Bray–Curtis algorithm, the abundance of each level, LEfSe analysis, network analysis, and PICRUSt analysis were carried out between the four groups and two sample types. Clinical and demographic data were compared using analysis of variance (ANOVA) or the nonparametric Kruskal–Wallis rank-sum test, depending on the normality of the data, using GraphPad Prism 8 (P < 0.05). Results OTU principal component analysis revealed a significant difference between healthy individuals and those with RC-SS. In the saliva of patients with rampant caries, the relative abundance of Firmicutes increased significantly at the phylum level. Further, Streptocpccus, Veillonella, Prevotella, and Dialister increased, while Neisseria and Haemophilus decreased at the genus level. Veillonella increased in the plaque samples of patients with rampant caries. Conclusion Both salivary and dental plaque composition were significantly different between healthy individuals and patients with rampant caries. This study provides a microbiological basis for exploring the etiology of rampant caries. Clinical relevance This study provides basic information on the flora of the oral cavity in adults with rampant caries in China. These findings could serve as a reference for the treatment of this disease.

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Customized Minimally Invasive Protocols for the Clinical and Microbiological Management of the Oral Microbiota

Abstract: In recent years, the personalization of periodontal clinical practice has led to the study of protocols with a proactive approach [...]

Cited by 27 publications

References 10 publications

The Associations of Cardiometabolic and Dietary Variables with Clinical Periodontitis in Adults with and without Type 2 Diabetes: A Cross-Sectional Study

The Associations of Cardiometabolic and Dietary Variables with Clinical Periodontitis in Adults with and without Type 2 Diabetes: A Cross-Sectional Study

Effect of lactobacillus reuteri-derived probiotic nano-formulation on recurrent aphthous stomatitis: a double-blinded randomized clinical trial

Effects of Sjogren’s syndrome and high sugar diet on oral microbiome in patients with rampant caries: a clinical study

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