Cut margins and disease control in oral cancers

Priya, SR; D'Cruz, AK; Pai, Prathamesh

doi:10.4103/0973-1482.95178

Cited by 47 publications

(57 citation statements)

References 18 publications

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“…It indicates a poor prognosis. According to an institutional study from India, the average disease free survival time is around 35 months (Priya et al, 2012). Retrospective analytical studies from hospitals present patterns of recurrence and the factors influencing it.…”

Section: Recurrencementioning

confidence: 99%

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Rao¹,

Mejía²,

Roberts‐Thomson³

et al. 2013

Asian Pacific Journal of Cancer Prevention

407

256

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The prevalence of oral cancers (OC) is high in Asian countries, especially in South and Southeast Asia. Asian distinct cultural practices such as betel-quid chewing, and varying patterns of tobacco and alcohol use are important risk factors that predispose to cancer of the oral cavity. The aim of this review is to provide an update on epidemiology of OC between 2000 and 2012. A literature search for this review was conducted on Medline for articles on OC from Asian countries. Some of the articles were also hand searched using Google. High incidence rates were reported from developing nations like India, Pakistan, Bangladesh, Taiwan and Sri Lanka. While an increasing trend has been observed in Pakistan, Taiwan and Thailand, a decreasing trend is seen in Philippines and Sri Lanka. The mean age of occurrence of cancer in different parts of oral cavity is usually between 51-55 years in most countries. The tongue is the leading site among oral cancers in India. The next most common sites in Asian countries include the buccal mucosa and gingiva. The 5 year survival rate has been low for OC, despite improvements in diagnosis and treatment. Tobacco chewing, smoking and alcohol are the main reasons for the increasing incidence rates. Low socioeconomic status and diet low in nutritional value lacking vegetables and fruits contribute towards the risk. In addition, viral infections, such as HPV and poor oral hygiene, are other important risk factors. Hence, it is important to control OC by screening for early diagnosis and controlling tobacco and alcohol use. It is also necessary to have cancer surveillance at the national-level to collect and utilise data for cancer prevention and control programs.

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Section: Recurrencementioning

confidence: 99%

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Rao¹,

Mejía²,

Roberts‐Thomson³

et al. 2013

Asian Pacific Journal of Cancer Prevention

407

256

View full text Add to dashboard Cite

show abstract

“…Oral tongue is a muscular organ, Hence a three dimensional concept of margins beyond the tumor is easily applicable. Usually, a measured intraoperative resection margin of 1 to 2 cm is recommended to achieve a microscopically clear margin of 5 mm [5,[8][9][10][11].…”

Section: Oral Tonguementioning

confidence: 99%

“…Conventionally, a measured distance between the tumor edge and the cut margins of the specimen gives the adequacy of surgical resection in head and neck squamous cell carcinoma [4]. A margin more than 5 (mm) is considered clear, less than 5 mm is close and less than one mm is denoted as involved [5]. But, this principle may not be universally applicable in all head and neck sites and their sub-sites.…”

Section: Introductionmentioning

confidence: 99%

Site-wise Differences in Adequacy of the Surgical resection Margins in Head and Neck Cancers

Vidhyadharan

Augustine

Kudpaje

et al. 2014

Indian J Surg Oncol

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Adequacy of surgical resection decided by the margin status is important in attaining a good local control and better survival in Head and neck Cancers. Conventionally, a measured distance between the tumor edge and the cut edge of the specimen is taken as the margin. A margin more than 5 millimeter (mm) is considered clear, less than 5 mm is close and less than one mm is denoted as involved. The concept of this adequacy varies between the different sites and subsites in head and neck. The purpose of this paper is to review the current evidence that describes the adequacy of surgical margin status and their variability among the sites and sub-sites in the head and neck.

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“…malignant disease left behind after ablative oncologic surgery leads to recurrent disease and adversely affects outcomes [8,9] . The literature is clear that in order to maximize survival, reduce recurrence, and improve quality of life for patients undergoing oncologic head and neck surgery, negative margins are paramount [10][11][12][13][14] .…”

Section: Reviewmentioning

confidence: 99%

How Close Are We to Real Time Optical Margin Control in Head and Neck Oncologic Surgery?

Miles

2016

Cancer Cell Microenviron

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The quest for negative margins during head and neck oncologic surgery continues to challenge surgeons worldwide. Current technological advances offer significant promise to advance the field and improve operative margin detection. This review focuses on current optical technology, which has been evaluated for intraoperative margin control in head and neck oncologic surgery. Many of the current systems have technical limitations and there is no current standard technology being applied in the field of head and neck oncology to enhance intraoperative margin control. Surgeons continue to rely on intraoperative frozen section analysis, however many optical systems have shown high rates of sensitivity and specificity when discriminating benign from malignant tissue. These technologies shows significant promise for intraoperative margin control and may be enhanced by targeted molecular imaging, or spectral analysis, in the future. Translational trials are rare and are the key to the path of independence from frozen section analysis.

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Cut margins and disease control in oral cancers

Abstract: Margins are an important predictor of disease control. The surgeon must aim for adequate margins at initial resection.

Cited by 47 publications

References 18 publications

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Epidemiology of Oral Cancer in Asia in the Past Decade- An Update (2000-2012)

Site-wise Differences in Adequacy of the Surgical resection Margins in Head and Neck Cancers

How Close Are We to Real Time Optical Margin Control in Head and Neck Oncologic Surgery?

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