Cut-off effects in biological activities of surfactants

Interaction of long-chain n-alcohols with fluid DOPC bilayers: a neutron diffraction study

“…In any case the dependence in Fig. 2 is in accord with the postulate that the bilayer thickness change due to length difference between admixture and lipid hydrocarbon chains should diminish with this difference decrease (Balgavý and Devínsky 1996).…”

“…This should produce a lateral compression that increases the thickness (Gallová et al 1995;Balgavý et al 1998;Karlovská et al 2004). The mismatch between the CnOH and DMPC hydrocarbon chain lengths should result in a thickness decrease in nonstressed bilayers (Balgavý and Devínsky 1996), but the lateral compression due to low hydration level acts in the opposite direction. This is the most probable cause of the strange thickness dependence in the paper of Pope et al (1984).…”

The structural diversity of DNA–neutral phospholipids–divalent metal cations aggregates: a small-angle synchrotron X-ray diffraction study

“…After the intercalation of cationic amphiphiles into the bilayer between zwitterionic phospholipid molecules, the bilayer surface becomes positively charged (Haydon and Myers, 1973;Requena and Haydon, 1985) and the bilayer structure is disturbed depending on the amphiphile concentration, alkyl chain length and counter-ion (Balgavý et al, 1984;Balgavý and Devínsky, 1996;Sarapuk et al, 1998). The smallest bilayer structural perturbation occurs when the cationic amphiphile and the lipid have approximately equal lengths of hydrocarbon chains (Balgavý and Devínsky, 1996;Gallová et al, 1990). that is determined by the DNA interaxial distance (Schiessel and Aranda-Espinoza, 2001).…”

Lipid based drug delivery systems: Kinetics by SANS

“…The intercalation of C 12 NO between DOPE molecules results in a lateral expansion of the interface, and a mismatch between the length of C 12 NO alkyl substituent and the length of hydrocarbon acyl chains of DOPE (18 carbons hydrophobic membrane core. These defects, eliminated by chain bending, lead to a decrease of the thickness (d C ) of the hydrophobic region [14,32]. In our previous work [15] we found that the thickness of the hydrophobic region of dioleoylphosphatidylcholine (DOPC) bilayer (d C =27.4±0.1 Å) decreases to d C = 24.9 Å, and the area per 1 molecule increases from A = 70.4 Å 2 (for DOPC) up to A= 106.6 Å 2 at C 12 NO:DOPC=1 mol/mol.…”