Cut-Off Value of Brachial-Ankle Pulse Wave Velocity to Predict Cardiovascular Disease in Hypertensive Patients: A Cohort Study

Kawai, Tatsuo; Ohishi, Mitsuru; Onishi, Masanori; Ito, Norihisa; Takeya, Yasushi; Maekawa, Yoshihiro; Rakugi, Hiromi

doi:10.5551/jat.15040

Cited by 62 publications

(51 citation statements)

References 23 publications

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“…We excluded 5506 subjects from the analyses (the details of the exclusions and inaccurate baPWV measurement 25 are described in Appendix S1 in the online-only Data Supplement). A final total of 13 381 subjects from 7 cohorts were included in the analysis for all-cause mortality (5 published studies 12,13,15,17,18 and 2 unpublished studies 14,16 ), and 14 673 participants from 8 studies (5 published studies 12,13,15,17,18 and 3 unpublished studies 11,14,16 ) were included in the analysis for CVD risk.…”

Section: Study Populationmentioning

confidence: 99%

“…This collaborative study included the data from 14 cohort studies conducted in Japan (9 published and 5 unpublished studies). [11][12][13][14][15][16][17][18][19][20][21][22][23][24] The study was conducted with the approval of the Ethical Guidelines Committee of Tokyo Medical University (No 2655. Figure 1 depicts the process used to select the study population.…”

Section: Study Populationmentioning

confidence: 99%

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Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease

Ohkuma¹,

Ninomiya²,

et al. 2017

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A rterial stiffness is well-recognized as an important predictor of development of cardiovascular disease (CVD), 1,2 and meta-analyses of prospective cohort studies have revealed that increase in the carotid-femoral pulse wave velocity (cfPWV) is associated with an increase in the risk of development of CVD. 3,4 However, the cfPWV is measured by tonometry or Doppler, which requires specialized training and exposure of the inguinal region. 5,6Abstract-An individual participant data meta-analysis was conducted in the data of 14 673 Japanese participants without a history of cardiovascular disease (CVD) to examine the association of the brachial-ankle pulse wave velocity (baPWV) with the risk of development of CVD. During the average 6.4-year follow-up period, 687 participants died and 735 developed cardiovascular events. A higher baPWV was significantly associated with a higher risk of CVD, even after adjustments for conventional risk factors (P for trend <0.001). When the baPWV values were classified into quintiles, the multivariableadjusted hazard ratio for CVD increased significantly as the baPWV quintile increased. The hazard ratio in the subjects with baPWV values in quintile 5 versus that in those with the values in quintile 1 was 3.50 (2.14-5.74; P<0.001). Correspondence to Hirofumi Tomiyama, Department of Cardiology, Tokyo Medical University, 6-7-1 Nishi-Shinjuku, Tokyo, Japan. E-mail tomiyama@ tokyo-med.ac.jp In the early 2000s, a simple device for measurement of the brachial-ankle pulse wave velocity (baPWV) was launched for clinical use. Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease An Individual Participant Data Meta-Analysis7 baPWV is automatically measured using a separate cuff for each of the 4 limbs by an oscillometric method. baPWV may be more easily applied in clinical practice than the cfPWV because of the simplicity and ease of its measurement.7,8 baPWV has been reported to be closely correlated with the directly measured aortic PWV and cfPWV. 9 A recent meta-analysis using summary data from the literature has demonstrated that higher levels of baPWV were associated with an increased risk of development of CVD.10 However, most of the studies included in the meta-analyses were conducted in patients with a high CVD risk (patients with CVD or end-stage renal disease), and thus, the usefulness of baPWV to assess the risk of development of CVD in subjects with a low to intermediate CVD risk as assessed using the Framingham risk score (FRS) had not been clearly elucidated. Furthermore, these studies did not determine the predictive ability for CVD over that of the traditional risk factors. Therefore, we conducted a meta-analysis using individual participant data (IPD) from prospective cohort studies to clarify whether baPWV could be used as an independent marker to predict the risk of development of CVD in subjects without preexisting CVD. Methods Study PopulationJ-BAVEL (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Pros...

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Section: Study Populationmentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease

Ohkuma¹,

Ninomiya²,

et al. 2017

Self Cite

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“…Previous reports have shown that baPWV was correlated well with cfPWV and predicted worse outcomes in hypertensive patients [29,30]. These studies suggest that the baPWV cut-off value was approximately 1750 cm/s, which was associated with increased cardiovascular events and mortality [9,10,31,32]. In this study, an overall prevalence of baPWV of more than 1750 cm/s was 11.9%.…”

Section: Discussionmentioning

confidence: 53%

“…A threshold of >1,750 cm/s for the baPWV was determined for the presence of SOD, which was the cut-off value of baPWV for predicting cardiovascular disease in previous studies [9,10].…”

Section: Definitions Of the Primary Outcomementioning

confidence: 99%

An Overview of the Applicability of Oryung-san as an Antihypertensive Agent

Jeong¹,

Kang²,

Kang³

et al. 2017

J Int Korean Med

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“…For example, the well-known study by Kawai et al [10,11] used baPWV as a measure of arterial stiffness. Its validity and utility have been proven in various clinical settings [12][13][14][15][16][17] and in meta-analyses [18,19], and many studies have investigated its clinical significance [9,20].…”

Section: Introductionmentioning

confidence: 99%

A genome-wide association study of the association between single nucleotide polymorphisms and brachial-ankle pulse wave velocity in healthy Koreans

Shin

Lim

et al. 2017

J Genet Med

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Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<5×10 -8 ) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<5×10 ) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

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Cut-Off Value of Brachial-Ankle Pulse Wave Velocity to Predict Cardiovascular Disease in Hypertensive Patients: A Cohort Study

Cited by 62 publications

References 23 publications

Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease

Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease

An Overview of the Applicability of Oryung-san as an Antihypertensive Agent

A genome-wide association study of the association between single nucleotide polymorphisms and brachial-ankle pulse wave velocity in healthy Koreans

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