Cut-off value of coronary flow velocity reserve by transthoracic Doppler echocardiography for diagnosis of significant left anterior descending artery stenosis in patients with coronary risk factors

Matsumura, Yoshiki; Hozumi, Takeshi; Watanabe, Hiroyuki; Fujimoto, Kohei; Sugioka, Kenichi; Takemoto, Yasuhiko; Shimada, Kenei; Muro, Takashi; Yoshiyama, Minoru; Takeuchi, Kazuhide; Yoshikawa, Junichi

doi:10.1016/j.amjcard.2003.08.042

Cited by 61 publications

(37 citation statements)

References 30 publications

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“…Indeed, a decrease in the release of endothelium-derived nitric oxide has been well documented in experimental animal models of hypertension as well as in hypertensive patients (23). Recently, we reported a significant correlation between CFVR, forearm endothelial function and asymmetric dimethylarginine, which is an endogenous (14,16).…”

Section: Discussionmentioning

confidence: 95%

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Clinical Implications of Assessing Coronary Flow Velocity Reserve and Plasma Endothelin-1 in Hypertensive Patients

et al. 2005

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Section: Discussionmentioning

confidence: 95%

“…CFVR was defined as the ratio of hyperemic to basal MDV. We adopted a CFVR of less than 2.0 as the cut-off value for the presence of significant coronary arterial stenosis, as has been done in published reports (14,16).…”

Section: Cfvr Measurement Using Transthoracic Doppler Echocardiographymentioning

confidence: 99%

Clinical Implications of Assessing Coronary Flow Velocity Reserve and Plasma Endothelin-1 in Hypertensive Patients

et al. 2005

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“…It is know that even as a "stand alone" technique TTE-CFR<2 has good sensitivity 89-92% and specificity 75-93% to predict significant LAD and PD coronary artery stenosis (>70% diameter stenosis) [2][3][4] . CFR-TTE together with 2-dimensional echocardiography provide better sensitivity up to 93% and still good specificity 80.6% for detection of diseased LAD 5 .…”

Section: Discussionmentioning

confidence: 99%

Significance of relative coronary flow reserve in patient with microvascular dysfunction to differentiate significant coronary artery stenosis

Tešić¹,

Đorđević-Dikić²,

Kalimanovska-Oštrić³

et al. 2017

Srce i krvni sudovi

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Introduction: Coronary flow reserve (CFR) is defined as a ratio of hyperemic-to-basal coronary flow velocity and it can be measured by a variety of methods. Transthoracic Doppler echocardiography (TTE) CFR became useful method to assess functional significance of coronary artery stenosis in both left anterior descending (LAD) and posterior descending coronary artery (PD). CFR is combined measure of the capacity of epicardial coronary artery and microcirculation to achieve maximal blood flow in response to hyperemic stimulation. Thus in patients with already impaired microcirculation and accordingly CFR, differentiation from presence of significant coronary stenosis is difficult without known coronary angiography. Case report: We present a case of patient with hypertrophic cardiomyopathy and diabetes, where relative CFR as the ratio of the CFRs of two coronary arteries helped us in decision making to do coronarography because of atypical chest pain and fatigue. Conclusion: In patients with known microvascular dysfunction and already impaired CFR, relative CFR might be helpful to differentiate presence of significant epicardial stenosis. Future studies are needed to obtain appropriate clinical implications of relative CFR in everyday practice. coronary flow reserve; relative coronary flow reserve; microcirculation; hypertrophic cardiomyopathy Abstract Key Words

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“…21 It was known that the cutoff value of CFR by echocardiography could be useful for the diagnosis of LAD stenosis. 22 In this paper, as changes of CFR at 8 months showed positive correlations with circulating angiogenic cells at day 1, the cutoff value of change of CFR was investigated for circulating angiogenic cell mobilization by a ROC curve. The result (Figure 4) showed that we could expect the recovery of CFR with an 82.61% sensitivity and 100% specificity if the absolute number of CD34+ cells was ≥5 ANC/μl.…”

Section: Discussionmentioning

confidence: 99%

Correlation Between Circulating Angiogenic Cell Mobilizations and Recovery of Coronary Flow Reserve in Patients With Acute Myocardial Infarction

Jeong

Hong

Park

et al. 2012

Circ J

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Cut-off value of coronary flow velocity reserve by transthoracic Doppler echocardiography for diagnosis of significant left anterior descending artery stenosis in patients with coronary risk factors

Cited by 61 publications

References 30 publications

Clinical Implications of Assessing Coronary Flow Velocity Reserve and Plasma Endothelin-1 in Hypertensive Patients

Clinical Implications of Assessing Coronary Flow Velocity Reserve and Plasma Endothelin-1 in Hypertensive Patients

Significance of relative coronary flow reserve in patient with microvascular dysfunction to differentiate significant coronary artery stenosis

Correlation Between Circulating Angiogenic Cell Mobilizations and Recovery of Coronary Flow Reserve in Patients With Acute Myocardial Infarction

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