Cut-Off Values of Blood Mercury Concentration in Relation to Increased Body Mass Index and Waist Circumference in Koreans

Bae, Su-Hyun; Park, Soo-Jung; Yeum, Kyung‐Jin; Choi, Beomhee; Kim, Young-Sang; Joo, Nam-Seok

doi:10.1136/jim-2015-000039

Cited by 9 publications

(6 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the study based on the 2011–2012 NHANES, the geometric mean of total blood mercury level was 0.70 (0.62–0.80) μg/L [men 0.71 (0.62–0.81) μg/L, women 0.69 (0.61–0.79) μg/L], and the Asian group had the highest blood mercury level [1.86 μg/L (1.58, 2.19)] [ 19 ] among the US population. Our study participants had lower blood mercury concentration, compared to KNHANES (2008–2012) [men 5.07 (5.00–5.14) μg/L and women 3.59 (3.55–3.63) μg/L] [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…A recent study reported that elderly adults, particularly those aged 60–69 years and Asians residing in the US communities had the highest exposure prevalence of methylmercury according to the National Health and Nutrition Examination Survey (NHANES) 2011–2012 [ 19 ]. In the Korea National Health and Nutrition Examination Survey (KNHANES, 2008–2012), mean values of blood mercury concentration were 5.07 ± 0.07 μg/L in males and 3.59 ± 0.04 μg/L in females [ 20 ] and they were higher than NHANES. Therefore, there is a need to investigate the elderly Asians vulnerable to mercury exposure for the association with liver function.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

et al. 2017

View full text Add to dashboard Cite

Background: Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly. Methods: We included 560 elderly participants (60 years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Many studies have investigated the high blood Hg levels in the Korean population. Some reported significant associations between Hg, high BMI, and metabolic syndromes [ 23 , 24 ], while others reported no associations or even negative associations [ 25 , 26 , 27 ]. Metabolic syndromes are associated with many factors, including dietary habits and living patterns, and some factors may have a stronger influence than Hg exposure.…”

Section: Discussionmentioning

confidence: 99%

Mercury Exposure and Associations with Hyperlipidemia and Elevated Liver Enzymes: A Nationwide Cross-Sectional Survey

Lee

Cho

Jeong

et al. 2020

Toxics

View full text Add to dashboard Cite

Mercury (Hg) has obesogenic properties. However, the associated health outcomes of population-level mercury exposure were unclear. This study investigated the relationships between blood mercury levels and obesity-related outcomes such as hyperlipidemia and elevated liver enzymes. Using the second cycle of the Korean National Environmental Health Survey (n = 6454), we performed logistic regression to examine the effects of Hg on hyperlipidemia and elevated liver enzymes. The blood mercury levels were significantly higher in the hyperlipidemia group (n = 3699, male: 4.03 μg/L, female: 2.83 μg/L) compared to the non-hyperlipidemia group (n = 2755, male: 3.48 μg/L, female: 2.69 μg/L), and high blood mercury levels were associated with an 11% higher risk of hyperlipidemia. The elevated liver enzymes group had higher mean blood mercury levels (n = 1189, male: 4.38 μg/L, female: 3.25 μg/L) than the normal group (n = 5265, male: 3.64 μg/L, female: 2.70 μg/L), and elevated blood mercury was associated with a 35% higher risk of elevated liver enzymes. Moreover, the effect was constant after adjusting for personal medications. These results indicate that mercury exposure is significantly associated with hyperlipidemia and elevated liver enzymes.

show abstract

“…The geometric mean of total blood mercury level was 5.07 μg/L in Korean males and 3.59 μg/L in Korean females from Korea National Health and Nutrition Examination Survey (KNHANES, 2008–2012) [ 42 ], 0.23 μg/L in the German Environmental Survey IV (2003–2008) [ 43 ], 0.70 μg/L based on the 2011–2012 NHANES in USA [ 44 ] and 3.13 μg/L in Bogota [ 45 ]. In Taiwan, the geometric mean of total blood mercury levels was 9.1 μg/L, 89 % of the maternal blood mercury concentrations exceeded the US National Research Council recommended value of 5.8 μg/L [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Association between heavy metal levels and acute ischemic stroke

et al. 2018

View full text Add to dashboard Cite

BackgroundFew studies have examined the relationship between the amounts of heavy metal and stroke incidence. The aim of this study was to explore the relationship between levels of heavy metals, including Pb, Hg, As, and Cd, in patients with acute ischemic stroke (AIS).MethodsWe selected patients with first-ever AIS onset within 1 week as our study group. Healthy controls were participants without a history of stroke or chronic disease, except hypertension. The serum levels of Pb, Hg, As, and Cd in participants in the experimental and control groups were determined. All participants received a 1-g infusion of edetate calcium disodium (EDTA). Urine specimens were collected for 24 h after EDTA infusion and measured for heavy metal levels.ResultsIn total, 33 patients with AIS and 39 healthy controls were enrolled in this study. The major findings were as follows: (1) The stroke group had a significantly lower level of serum Hg (6.4 ± 4.3 μg/L vs. 9.8 ± 7.0 μg/L, P = 0.032, OR = 0.90, 95% CI = 0.81–0.99) and a lower level of urine Hg (0.7 ± 0.7 μg/L vs. 1.2 ± 0.6 μg/L, P = 0.006, OR = 0.27, 95% CI = 0.11–0.68) than the control group. (2) No significant difference in serum Pb (S-Pb), As (S-As), and Cd (S-Cd) levels and urine Pb (U-Pb), As (U-As) and Cd (U-Cd) levels was observed in either group.ConclusionsOur study found low levels of serum and urine Hg in first-ever patients with AIS, providing new evidence of dysregulated heavy metals in patients with AIS.Electronic supplementary materialThe online version of this article (10.1186/s12929-018-0446-0) contains supplementary material, which is available to authorized users.

show abstract

Cut-Off Values of Blood Mercury Concentration in Relation to Increased Body Mass Index and Waist Circumference in Koreans

Cited by 9 publications

References 30 publications

Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study

Mercury Exposure and Associations with Hyperlipidemia and Elevated Liver Enzymes: A Nationwide Cross-Sectional Survey

Association between heavy metal levels and acute ischemic stroke

Contact Info

Product

Resources

About