Cutaneous Adenomyoepithelioma: Report of a Case and Review of the Literature

González, Iván; Gonzalez, Manuel Lora; Kroh, Jan-Marie; Fraga, Garth

doi:10.1097/dad.0000000000000519

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…Primary cutaneous AME is analogous to AME of the breast and is considered as an uncommon skin adnexal tumor 5 . Cutaneous AMEs have been reported to be associated with another adnexal tumor, including apocrine hidrocystoma, mixed tumor, and spiroadenoma, in several previous reports 7–9 . In our case, biphasic components of epithelial and myoepithelial cells formed a defined cutaneous nodule with a focal lobulated architecture.…”

Section: Discussionsupporting

confidence: 50%

“…AME or malignant AME has also been reported in the salivary glands, lungs, vulva, and skin 5 . Cutaneous AME is exceedingly rare, and there are few documented cases in the English literature 5–9 . In addition to AME, skin adnexal tumors displaying two cell populations include apocrine hidrocystoma, mixed tumor, and adenoid cystic carcinoma (ACC).…”

Section: Introductionmentioning

confidence: 99%

“…In addition to AME, skin adnexal tumors displaying two cell populations include apocrine hidrocystoma, mixed tumor, and adenoid cystic carcinoma (ACC). Apocrine hidrocystoma presents as cystic epithelium exhibiting apocrine snouts with peripheral myoepithelial cells 7 . Myxoid stroma with solitary myoepithelial cells detaching from the periphery of ductal structures is distinctive of a mixed tumor 5,8 .…”

Section: Introductionmentioning

confidence: 99%

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Cutaneous adenomyoepithelioma with histopathological heterogeneity: A case report

Shiomi

Matsuno

Nishimura

et al. 2021

Pathology International

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Some skin adnexal tumors display both epithelial and myoepithelial cell populations and can be broadly categorized as biphasic tumors. These include apocrine hidrocystoma, mixed tumor, adenomyoepithelioma (AME), and adenoid cystic carcinoma (ACC). Myoepithelioma is the myoepithelial cell‐predominant type in this category. Cutaneous AME is exceedingly rare and usually has a benign prognosis, but it is considered to have the potential for local recurrence and metastasis. We report the case of a 57‐year‐old man with a 1‐year history of an ulcerated nodule on his scalp. Microscopically, it was a defined cutaneous nodule with a focal lobulated architecture, composed of epithelial cells forming ducts and myoepithelial cells distributed around the ducts. In addition to these findings of typical AME, the present case focally revealed atypical features, such as increased mitotic activity (7/10 high power fields), invasive growth, and necrosis. However, cytological atypia was not significant. We conclusively diagnosed cutaneous AME with atypical features, suggesting malignant potential. Moreover, areas showing appearances similar to apocrine hidrocystoma, mixed tumor, myoepithelioma, and ACC were focally observed. We present a unique case of cutaneous AME exhibiting histopathological heterogeneity. The recognition of morphological variation could be helpful in appropriately diagnosing and treating AME of the skin.

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Section: Discussionsupporting

confidence: 50%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cutaneous adenomyoepithelioma with histopathological heterogeneity: A case report

Shiomi

Matsuno

Nishimura

et al. 2021

Pathology International

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“…6 To the best of our knowledge, no cases of malignant cAME have been reported. [6][7][8][9][10][11][12][13] A sparse amount of malignant AME of the breast has been reported. 12,13 Malignant changes most commonly involve the epithelial component when they occur.…”

Section: Discussionmentioning

confidence: 92%

“…1,2 Additional reports of rare tumors with both glandular and myoepithelial components have been reported in the literature and referred to as "adenomyoepithelioma." 6 Adenomyoepitheliomas are more commonly found in female patients and have been reported in the breast, tonsil, sweat glands, and lung. [7][8][9][10][11] The most common location of adenomyoepithelioma is the breast.…”

Section: Discussionmentioning

confidence: 99%

Nodule on the Great Toe of a 32-Year-Old Man: Answer

Newkirk

Shanahan²,

Mayr³

et al. 2021

The American Journal of Dermatopathology

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ANSWERClinical Course. Based on the histological findings, the tumor was classified as an adenomyoepithelial tumor and the patient was referred to Mohs surgery for complete resection with nail plate excision to ensure negative margins and prevent recurrence. Excision of the remaining lesion with a 2 mm margin of normal tissue was completed down to the level of the periosteum. A review of horizontal frozen sections intraoperatively showed no residual tumor at the margins examined, and the surgical defect was closed in a linear fashion along the periungual fold (Fig. 3A). At follow-up, there was no regrowth of the tumor at 7 months postoperatively (Fig. 3B). FIGURE 3. A, B, Closure immediately after excision (A) and good healing without recurrence 7 months postoperatively (B).

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Apocrine Hidradenoma and Adenomyoepithelioma: Entities on a Biological Continuum of Adnexal Neoplasia

MacKinnon

Moss

Pasternak

et al. 2020

The American Journal of Dermatopathology

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Apocrine hidradenomas (AH) once believed to harbor myoepithelial cells are now considered pure epithelial neoplasms. They are categorized separately from adenomyoepitheliomas which consist of apocrine epithelial and myoepithelial components. Reports of myoepithelial tumors arising in AH have suggested a link between the 2. Our goal was to explore whether cases diagnosed on routine microscopy as AH harbored occult myoepithelial elements, which would be disclosed by an immunohistochemical evaluation. Twenty-nine such cases, derived from a teaching collection of one of the authors, formed the basis of the study. Clinical and demographic data were documented, and morphological details of the cases were recorded. A panel of immunohistochemistry (AE1AE3, CK8/18, epithelial membrane antigen, p63, S100 protein, glial fibrillary acid protein, calponin, alpha actin, and others), designed to identify myoepithelial cells, was used. The population consisted of 14 women and 15 men (mean age 55.8; range 26–82 years). The tumors, located on the head/neck (14), limbs (10), and trunk (5), were solid (2) and solid/cystic (27). They exhibited varied (often combined) cytological elements (clear, squamoid, polygonal, and mucinous cells). On immunohistochemistry, aggregates of myoepithelial cells were identified in 5 (17%) cases. Four were calponin+ and AE1AE3+; they occupied ≤30% of tumor volumes and exhibited fusiform cytomorphology. One was S100 protein+ and AE1AE3+; it occupied 70% of tumor volume and exhibited polygonal cytomorphology. The gradation in the volume of myoepithelial elements disclosed by immunohistochemistry in a subset of our cases suggests that AH and adenomyoepitheliomas exist on a biological continuum of adnexal neoplasia. The diagnostic categorization of lesions with dual elements requires further study, but we propose that the term adenomyoepithelioma be restricted to those in which myoepithelial cells constitute ≥25% of tumor volume.

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Cutaneous Adenomyoepithelioma: Report of a Case and Review of the Literature

Cited by 6 publications

References 16 publications

Cutaneous adenomyoepithelioma with histopathological heterogeneity: A case report

Cutaneous adenomyoepithelioma with histopathological heterogeneity: A case report

Nodule on the Great Toe of a 32-Year-Old Man: Answer

Apocrine Hidradenoma and Adenomyoepithelioma: Entities on a Biological Continuum of Adnexal Neoplasia

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