Cutaneous Adverse Drug Reactions-A Study of Clinical Patterns, Causality, Severity &amp; Preventability

Verma, Reena; Tiwari, Dr.Shreyansh; Gupta, Dr.CM; Verma, Nitin

doi:10.9790/0853-1374102109

Cited by 10 publications

(21 citation statements)

References 26 publications

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“…Female predominance (66.08%) was seen in this study. This is seen in accordance with studies conducted by Verma et al, Pudukadan et al and Chatterjee et al [12][13][14] This is however in contrast to studies where male predominance has been observed. 15,16 57.50% cases of ADRs were in the age group 21-40 years, also reported by Verma et al, Sharma et al, Leape et al had also observed that adults aged 20-49 years were at greatest risk of antibiotics-related drug eruptions, probably due to increased exposure to antibiotics.…”

Section: Discussioncontrasting

confidence: 40%

“…Verma et al and Sharma et al also reported similar findings. 12,16 Some other studies found fixed drug eruptions as the most common drug eruption followed by maculopapular rash and urticaria. 19 In this study steroids were implicated with maximum number of ADRs.…”

Section: Discussionmentioning

confidence: 99%

“…15,16 57.50% cases of ADRs were in the age group 21-40 years, also reported by Verma et al, Sharma et al, Leape et al had also observed that adults aged 20-49 years were at greatest risk of antibiotics-related drug eruptions, probably due to increased exposure to antibiotics. 12,16,17 However, few studies have noted that the elderly are more commonly affected. 18 Erythematous maculopapular lesions were the most commonly reported ADR in the study.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

To study the pattern of suspected adverse drug reactions in patients coming to the department of dermatology in Gauhati Medical College and Hospital, Guwahati, Assam, India

Borah

Lahkar

Singha

et al. 2016

Int J Basic Clin Pharmacol

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We propose a new realisation of light Dirac neutrino mass and dark matter (DM) within the framework of a non-Abelian discrete flavour symmetry A 4 . In addition to A 4 , we also consider a Z 2 and an unbroken global lepton number symmetry U (1) L to keep unwanted terms away while guaranteeing the Dirac nature of light neutrinos. The field content, their transformations and flavon vacuum alignments are chosen in such a way that the type-I Dirac seesaw generates only one light Dirac neutrino mass while the other two masses arise from scotogenic contributions at one-loop. The symmetry breaking of A 4 leaves a remnant Z 2 symmetry responsible for stabilising DM. Dirac nature of light neutrinos introduces additional relativistic degrees of freedom ∆N eff within reach of cosmic microwave background experiments.

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Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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To study the pattern of suspected adverse drug reactions in patients coming to the department of dermatology in Gauhati Medical College and Hospital, Guwahati, Assam, India

Borah

Lahkar

Singha

et al. 2016

Int J Basic Clin Pharmacol

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“…2 An adverse cutaneous drug reaction caused by a drug is any undesirable change in the structure or function of the skin, it's appendages or mucous membranes and it encompasses all adverse events related to drug eruption, regardless of etiology. 3 Although many of the skin reactions are not serious, some are lifethreatening such as Angio-edema, Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. 4 Studies have found the overall incidence of adverse drug reactions in skin in developed countries as 1-3 % and in the developing countries it is higher between 2-5%.…”

Section: Introductionmentioning

confidence: 99%

Adverse drug reactions in the department of dermatology at a tertiary care hospital: a prospective study

Sowmyanarayan¹,

Rajeshwari²,

Banerjee³

2017

Int J Basic Clin Pharmacol

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Background: To study cutaneous adverse drug reactions with regard to their clinical pattern. etiology, causality and severity.Methods: It was a prospective study undertaken in a 300 bedded tertiary care hospital. Patients with cutaneous ADRs presenting in Dermatology OPD were studied. Causality and severity of the adverse drug reactions were analysed and other parameters such as gender wise distribution of the ADRs and types of ADR were studied.Results: 35 cases of ADRs were enrolled for the study in the duration of Sept.2016 to May 2017. The majority of the patients were in the age group of 21-30 years (37.14%). The most common CADRs were Acne vulgaris (22.86%), followed by Fixed Drug eruption (11.43%) and Tinea cruris (8.57%). The most common class of drugs causing ADRs were topical steroids (64%), followed by non-steroidal anti-inflammatory drugs (14.29%).Conclusions: Female preponderance was seen. Topical steroids were the most offending drug followed by Diclofenac Sodium, the analgesic. Causality assessment showed a high score of Certain category. These variations may be explained by variations in drug usage patterns. The knowledge of the adverse drug reactions and the drugs causing them is essential for the clinician so that the choice of drug therapy can be made keeping these adverse drug reactions in mind.

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“…[1] An important risk factor for developing ADR is the previous occurrence of ADR. Re-exposure to offending drugs due to poor documentation can cause the patient to experience the same ADR again, thus emphasizing the importance of the accurate documentation of ADR at the time of the event and providing relevant information to the patient about the ADR will help prevent its further occurrence.…”

Section: Introductionmentioning

confidence: 99%

A Study of Adverse Drug Reactions in Patients Treated with Penicillins in a Rural Tertiary Care Hospital

Patil¹,

Raikar²,

Bhaskar³

et al. 2016

IJPCS

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Background: Adverse drug reactions (ADR) are rated as the fifth leading cause of death among all diseases. Approximately 5-8% of all hospitalization worldwide is due to ADR. Objectives: The present study was conducted with the aim of analyzing the pattern of Adverse Drug Reactions occurring from penicillins, their manifestations and severity. Methods: A non interventional observational prospective study was conducted over 2 years from Jan 2014 to Dec 2015 in KIMS Narketpally. The red boxes for dropping the filled yellow adverse drug reactions forms were installed in all the wards and outpatient departments. Additional information and missing data was obtained personally by either consulting the physician or through case sheets. Results: The most common penicillin implicated in causation of adverse drug reactions was combination of amoxicillin and clavulanic acid (54%), followed by Piperacillin (21%). Most of the reactions were of moderate severity. The most commonly observed adverse drug reactions were dermatological reactions (37%). Majority of the adverse drug reactions belonged to probable category (71%) according to WHO scale. Conclusion: Dermatological reactions are the most common adverse drug reactions occurring due to penicillin and combination of amoxicillin and clavulanic acid was the most common causative penicillin. The health care providers should make an attempt for early detections of ADRs and be vigilant about safety profile monitoring of the prescribed medicines. This will not only decrease the morbidity and mortality but also the health care cost.

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Cutaneous Adverse Drug Reactions-A Study of Clinical Patterns, Causality, Severity & Preventability

Abstract: Abstract:Aim-to study CADRs

Cited by 10 publications

References 26 publications

To study the pattern of suspected adverse drug reactions in patients coming to the department of dermatology in Gauhati Medical College and Hospital, Guwahati, Assam, India

To study the pattern of suspected adverse drug reactions in patients coming to the department of dermatology in Gauhati Medical College and Hospital, Guwahati, Assam, India

Adverse drug reactions in the department of dermatology at a tertiary care hospital: a prospective study

A Study of Adverse Drug Reactions in Patients Treated with Penicillins in a Rural Tertiary Care Hospital

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